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Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats.
Psychopharmacology (Berl). 2009 Jul; 204(4):715-24.P

Abstract

RATIONALE

There has been increased recreational use of dimethyltryptamine (DMT), but little is known of its discriminative stimulus effects.

OBJECTIVES

The present study assessed the similarity of the discriminative stimulus effects of DMT to other types of hallucinogens and to psychostimulants.

METHODS

Rats were trained to discriminate DMT from saline. To test the similarity of DMT to known hallucinogens, the ability of (+)-lysergic acid diethylamide (LSD), (-)-2,5-dimethoxy-4-methylamphetamine (DOM), (+)-methamphetamine, or (+/-)3,4-methylenedioxymethyl amphetamine (MDMA) to substitute in DMT-trained rats was tested. The ability of DMT to substitute in rats trained to discriminate each of these compounds was also tested. To assess the degree of similarity in discriminative stimulus effects, each of the compounds was tested for substitution in all of the other training groups.

RESULTS

LSD, DOM, and MDMA all fully substituted in DMT-trained rats, whereas DMT fully substituted only in DOM-trained rats. Full cross-substitution occurred between DMT and DOM, LSD and DOM, and (+)-methamphetamine and MDMA. MDMA fully substituted for (+)-methamphetamine, DOM, and DMT, but only partially for LSD. In MDMA-trained rats, LSD and (+)-methamphetamine fully substituted, whereas DMT and DOM did not fully substitute. No cross-substitution was evident between (+)-methamphetamine and DMT, LSD, or DOM.

CONCLUSIONS

DMT produces discriminative stimulus effects most similar to those of DOM, with some similarity to the discriminative stimulus effects of LSD and MDMA. Like DOM and LSD, DMT seems to produce predominately hallucinogenic-like discriminative stimulus effects and minimal psychostimulant effects, in contrast to MDMA which produced hallucinogen- and psychostimulant-like effects.

Authors+Show Affiliations

Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107-2699, USA. mgatch@hsc.unt.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19288085

Citation

Gatch, Michael B., et al. "Comparison of the Discriminative Stimulus Effects of Dimethyltryptamine With Different Classes of Psychoactive Compounds in Rats." Psychopharmacology, vol. 204, no. 4, 2009, pp. 715-24.
Gatch MB, Rutledge MA, Carbonaro T, et al. Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats. Psychopharmacology (Berl). 2009;204(4):715-24.
Gatch, M. B., Rutledge, M. A., Carbonaro, T., & Forster, M. J. (2009). Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats. Psychopharmacology, 204(4), 715-24. https://doi.org/10.1007/s00213-009-1501-z
Gatch MB, et al. Comparison of the Discriminative Stimulus Effects of Dimethyltryptamine With Different Classes of Psychoactive Compounds in Rats. Psychopharmacology (Berl). 2009;204(4):715-24. PubMed PMID: 19288085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats. AU - Gatch,Michael B, AU - Rutledge,Margaret A, AU - Carbonaro,Theresa, AU - Forster,Michael J, Y1 - 2009/03/14/ PY - 2008/06/03/received PY - 2009/02/22/accepted PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2009/8/1/medline SP - 715 EP - 24 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 204 IS - 4 N2 - RATIONALE: There has been increased recreational use of dimethyltryptamine (DMT), but little is known of its discriminative stimulus effects. OBJECTIVES: The present study assessed the similarity of the discriminative stimulus effects of DMT to other types of hallucinogens and to psychostimulants. METHODS: Rats were trained to discriminate DMT from saline. To test the similarity of DMT to known hallucinogens, the ability of (+)-lysergic acid diethylamide (LSD), (-)-2,5-dimethoxy-4-methylamphetamine (DOM), (+)-methamphetamine, or (+/-)3,4-methylenedioxymethyl amphetamine (MDMA) to substitute in DMT-trained rats was tested. The ability of DMT to substitute in rats trained to discriminate each of these compounds was also tested. To assess the degree of similarity in discriminative stimulus effects, each of the compounds was tested for substitution in all of the other training groups. RESULTS: LSD, DOM, and MDMA all fully substituted in DMT-trained rats, whereas DMT fully substituted only in DOM-trained rats. Full cross-substitution occurred between DMT and DOM, LSD and DOM, and (+)-methamphetamine and MDMA. MDMA fully substituted for (+)-methamphetamine, DOM, and DMT, but only partially for LSD. In MDMA-trained rats, LSD and (+)-methamphetamine fully substituted, whereas DMT and DOM did not fully substitute. No cross-substitution was evident between (+)-methamphetamine and DMT, LSD, or DOM. CONCLUSIONS: DMT produces discriminative stimulus effects most similar to those of DOM, with some similarity to the discriminative stimulus effects of LSD and MDMA. Like DOM and LSD, DMT seems to produce predominately hallucinogenic-like discriminative stimulus effects and minimal psychostimulant effects, in contrast to MDMA which produced hallucinogen- and psychostimulant-like effects. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/19288085/Comparison_of_the_discriminative_stimulus_effects_of_dimethyltryptamine_with_different_classes_of_psychoactive_compounds_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-009-1501-z DB - PRIME DP - Unbound Medicine ER -