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Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts.
Phytother Res. 2009 Oct; 23(10):1453-7.PR

Abstract

Pharmacological assay guided purification of an ethanol extract of Tilia petiolaris DC. inflorescences resulted in the isolation and identification of isoquercitrin (ISO), quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and kaempferol 3-O-glucoside-7-O-rhamnoside (KAE). The behavioral actions of these glycosylated flavonoids were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in mice. QUE (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings. Meanwhile QUE at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium thiopental-induced time of loss of the righting reflex suggesting a clear depressant action. The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia.

Authors+Show Affiliations

Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19288528

Citation

Loscalzo, Leonardo M., et al. "Neuroactive Flavonoid Glycosides From Tilia Petiolaris DC. Extracts." Phytotherapy Research : PTR, vol. 23, no. 10, 2009, pp. 1453-7.
Loscalzo LM, Wasowski C, Marder M. Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts. Phytother Res. 2009;23(10):1453-7.
Loscalzo, L. M., Wasowski, C., & Marder, M. (2009). Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts. Phytotherapy Research : PTR, 23(10), 1453-7. https://doi.org/10.1002/ptr.2800
Loscalzo LM, Wasowski C, Marder M. Neuroactive Flavonoid Glycosides From Tilia Petiolaris DC. Extracts. Phytother Res. 2009;23(10):1453-7. PubMed PMID: 19288528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts. AU - Loscalzo,Leonardo M, AU - Wasowski,Cristina, AU - Marder,Mariel, PY - 2009/3/17/entrez PY - 2009/3/17/pubmed PY - 2010/1/27/medline SP - 1453 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 10 N2 - Pharmacological assay guided purification of an ethanol extract of Tilia petiolaris DC. inflorescences resulted in the isolation and identification of isoquercitrin (ISO), quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and kaempferol 3-O-glucoside-7-O-rhamnoside (KAE). The behavioral actions of these glycosylated flavonoids were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in mice. QUE (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings. Meanwhile QUE at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium thiopental-induced time of loss of the righting reflex suggesting a clear depressant action. The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/19288528/Neuroactive_flavonoid_glycosides_from_Tilia_petiolaris_DC__extracts_ L2 - https://doi.org/10.1002/ptr.2800 DB - PRIME DP - Unbound Medicine ER -