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[Influence of ginger-partitioned moxibustion on serum NO and plasma endothelin-1 contents in patients with primary dysmenorrhea of cold-damp stagnation type].
Zhen Ci Yan Jiu. 2008 Dec; 33(6):409-12.ZC

Abstract

OBJECTIVE

To explore the mechanism of ginger-partitioned moxibustion in the treatment of cold-damp stagnation type primary dysmenorrhea (PD) patients.

METHODS

A total of 209 PD outpatients of cold-damp stagnation type from 3 hospitals were randomized into moxibustion group (n = 105) who were treated with ginger-partitioned moxibustion, and control group (n = 104) who were asked to take Yueyue Shu Granules (an effective patent drug for PD). Ginger-partitioned moxibustion was applied to Shenque (CV 8) and Guanyuan (CV 4) from the menstrual onset on for the first course and 3 days before the onset for the second and third course, continuously for 3 days. Before and after the treatment, plasma endothelin-1 (ET-1) and serum nitric oxide (NO) contents in those patients (n = 40/group) and normal women (n = 20) experiencing menstrual period were determined by radioimmunoassay and nitrate reductase method.

RESULTS

After the treatment, of the 105 and 104 cases in moxibustion and control groups, 58 and 32 cured, 37 and 33 markedly effective, 5 and 24 effective, 5 and 15 failed, with the effective rates being 95.24% and 85.58% respectively. The therapeutic effect of moxibustion group was significantly better than that of control group (P<0.05). Before treatment, in comparison with normal group, plasma ET-1 contents in both moxibustion and control groups were significantly higher (P<0.01), while serum NO contents in these two groups markedly lower (P<0.01). After the treatment, self-comparison of both moxibustion and control groups showed that plasma ET-1 decreased significantly and serum NO levels in increased considerably (P<0.05, P<0.01), and the therapeutic effect of moxibustion group was markedly superior than that of control group in lowering plasma ET-1 (P<0.01).

CONCLUSION

Ginger-partitioned moxibustion is effective in relieving primary dysmenorrhea patients' abdominal pain, which may be closely associated with its actions in lowering plasma ET-1 level and raising serum NO contents.

Authors+Show Affiliations

College of Chinese Medicine, Hebei Medical University, Shijiazhuang 050091, China. 1952yjj@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19288904

Citation

Yang, Ji-jun, et al. "[Influence of Ginger-partitioned Moxibustion On Serum NO and Plasma Endothelin-1 Contents in Patients With Primary Dysmenorrhea of Cold-damp Stagnation Type]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 33, no. 6, 2008, pp. 409-12.
Yang JJ, Sun LH, She YF, et al. [Influence of ginger-partitioned moxibustion on serum NO and plasma endothelin-1 contents in patients with primary dysmenorrhea of cold-damp stagnation type]. Zhen Ci Yan Jiu. 2008;33(6):409-12.
Yang, J. J., Sun, L. H., She, Y. F., Ge, J. J., Li, X. H., & Zhang, R. J. (2008). [Influence of ginger-partitioned moxibustion on serum NO and plasma endothelin-1 contents in patients with primary dysmenorrhea of cold-damp stagnation type]. Zhen Ci Yan Jiu = Acupuncture Research, 33(6), 409-12.
Yang JJ, et al. [Influence of Ginger-partitioned Moxibustion On Serum NO and Plasma Endothelin-1 Contents in Patients With Primary Dysmenorrhea of Cold-damp Stagnation Type]. Zhen Ci Yan Jiu. 2008;33(6):409-12. PubMed PMID: 19288904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of ginger-partitioned moxibustion on serum NO and plasma endothelin-1 contents in patients with primary dysmenorrhea of cold-damp stagnation type]. AU - Yang,Ji-jun, AU - Sun,Li-hong, AU - She,Yan-fen, AU - Ge,Jian-jun, AU - Li,Xin-hua, AU - Zhang,Rui-juan, PY - 2009/3/18/entrez PY - 2009/3/18/pubmed PY - 2009/4/10/medline SP - 409 EP - 12 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 33 IS - 6 N2 - OBJECTIVE: To explore the mechanism of ginger-partitioned moxibustion in the treatment of cold-damp stagnation type primary dysmenorrhea (PD) patients. METHODS: A total of 209 PD outpatients of cold-damp stagnation type from 3 hospitals were randomized into moxibustion group (n = 105) who were treated with ginger-partitioned moxibustion, and control group (n = 104) who were asked to take Yueyue Shu Granules (an effective patent drug for PD). Ginger-partitioned moxibustion was applied to Shenque (CV 8) and Guanyuan (CV 4) from the menstrual onset on for the first course and 3 days before the onset for the second and third course, continuously for 3 days. Before and after the treatment, plasma endothelin-1 (ET-1) and serum nitric oxide (NO) contents in those patients (n = 40/group) and normal women (n = 20) experiencing menstrual period were determined by radioimmunoassay and nitrate reductase method. RESULTS: After the treatment, of the 105 and 104 cases in moxibustion and control groups, 58 and 32 cured, 37 and 33 markedly effective, 5 and 24 effective, 5 and 15 failed, with the effective rates being 95.24% and 85.58% respectively. The therapeutic effect of moxibustion group was significantly better than that of control group (P<0.05). Before treatment, in comparison with normal group, plasma ET-1 contents in both moxibustion and control groups were significantly higher (P<0.01), while serum NO contents in these two groups markedly lower (P<0.01). After the treatment, self-comparison of both moxibustion and control groups showed that plasma ET-1 decreased significantly and serum NO levels in increased considerably (P<0.05, P<0.01), and the therapeutic effect of moxibustion group was markedly superior than that of control group in lowering plasma ET-1 (P<0.01). CONCLUSION: Ginger-partitioned moxibustion is effective in relieving primary dysmenorrhea patients' abdominal pain, which may be closely associated with its actions in lowering plasma ET-1 level and raising serum NO contents. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/19288904/[Influence_of_ginger_partitioned_moxibustion_on_serum_NO_and_plasma_endothelin_1_contents_in_patients_with_primary_dysmenorrhea_of_cold_damp_stagnation_type]_ L2 - https://medlineplus.gov/periodpain.html DB - PRIME DP - Unbound Medicine ER -