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Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk.
J Epidemiol Community Health. 2009 Jul; 63(7):582-8.JE

Abstract

BACKGROUND

Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated with a reduction in cardiovascular risk. However, the effects of changes in dietary fibre on risk factor levels have not been evaluated in free-living individuals. Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects.

METHODS

772 high-risk subjects (age 69+/-5 years) were assigned to a low-fat diet or two Mediterranean-style diets. All participants received behavioural and nutritional education, including recommendations for increasing the consumption of vegetables, fruits, and legumes. Changes in food and nutrient intake, body weight, blood pressure, lipid profiles, glucose control and inflammatory markers were evaluated.

RESULTS

Most participants increased consumption of vegetable products, but the increase in dietary fibre exhibited wide between-subject variability (6-65 g/day). Body weight, waist circumference, and mean systolic and diastolic blood pressure decreased across quintiles of fibre intake (p<0.005; all). Reductions in fasting glucose and total cholesterol levels, and increments in HDL cholesterol were highest among participants in the upper 20% of fibre intake (p = 0.04 and 0.02 respectively). Plasma concentrations of C-reactive protein, but not those of inflammatory cytokines, decreased in parallel with increasing dietary fibre (p = 0.04). Significant reductions in LDL cholesterol were observed only among participants with the greatest increases in soluble fibre intake (p = 0.04).

CONCLUSIONS

Increasing dietary fibre intake with natural foods is associated with reductions in classical and novel cardiovascular risk factors in a high-risk cohort.

Authors+Show Affiliations

Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain. restruch@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19289389

Citation

Estruch, R, et al. "Effects of Dietary Fibre Intake On Risk Factors for Cardiovascular Disease in Subjects at High Risk." Journal of Epidemiology and Community Health, vol. 63, no. 7, 2009, pp. 582-8.
Estruch R, Martínez-González MA, Corella D, et al. Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. J Epidemiol Community Health. 2009;63(7):582-8.
Estruch, R., Martínez-González, M. A., Corella, D., Basora-Gallisá, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Escoda, R., Pena, M. A., Diez-Espino, J., Lahoz, C., Lapetra, J., Sáez, G., & Ros, E. (2009). Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. Journal of Epidemiology and Community Health, 63(7), 582-8. https://doi.org/10.1136/jech.2008.082214
Estruch R, et al. Effects of Dietary Fibre Intake On Risk Factors for Cardiovascular Disease in Subjects at High Risk. J Epidemiol Community Health. 2009;63(7):582-8. PubMed PMID: 19289389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. AU - Estruch,R, AU - Martínez-González,M A, AU - Corella,D, AU - Basora-Gallisá,J, AU - Ruiz-Gutiérrez,V, AU - Covas,M I, AU - Fiol,M, AU - Gómez-Gracia,E, AU - López-Sabater,M C, AU - Escoda,R, AU - Pena,M A, AU - Diez-Espino,J, AU - Lahoz,C, AU - Lapetra,J, AU - Sáez,G, AU - Ros,E, AU - ,, Y1 - 2009/03/15/ PY - 2009/3/18/entrez PY - 2009/3/18/pubmed PY - 2010/6/19/medline SP - 582 EP - 8 JF - Journal of epidemiology and community health JO - J Epidemiol Community Health VL - 63 IS - 7 N2 - BACKGROUND: Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated with a reduction in cardiovascular risk. However, the effects of changes in dietary fibre on risk factor levels have not been evaluated in free-living individuals. Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects. METHODS: 772 high-risk subjects (age 69+/-5 years) were assigned to a low-fat diet or two Mediterranean-style diets. All participants received behavioural and nutritional education, including recommendations for increasing the consumption of vegetables, fruits, and legumes. Changes in food and nutrient intake, body weight, blood pressure, lipid profiles, glucose control and inflammatory markers were evaluated. RESULTS: Most participants increased consumption of vegetable products, but the increase in dietary fibre exhibited wide between-subject variability (6-65 g/day). Body weight, waist circumference, and mean systolic and diastolic blood pressure decreased across quintiles of fibre intake (p<0.005; all). Reductions in fasting glucose and total cholesterol levels, and increments in HDL cholesterol were highest among participants in the upper 20% of fibre intake (p = 0.04 and 0.02 respectively). Plasma concentrations of C-reactive protein, but not those of inflammatory cytokines, decreased in parallel with increasing dietary fibre (p = 0.04). Significant reductions in LDL cholesterol were observed only among participants with the greatest increases in soluble fibre intake (p = 0.04). CONCLUSIONS: Increasing dietary fibre intake with natural foods is associated with reductions in classical and novel cardiovascular risk factors in a high-risk cohort. SN - 1470-2738 UR - https://www.unboundmedicine.com/medline/citation/19289389/Effects_of_dietary_fibre_intake_on_risk_factors_for_cardiovascular_disease_in_subjects_at_high_risk_ L2 - https://jech.bmj.com/lookup/pmidlookup?view=long&amp;pmid=19289389 DB - PRIME DP - Unbound Medicine ER -