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Global standardisation of HbA1c.
Malays J Pathol. 2008 Dec; 30(2):67-71.MJ

Abstract

HbA1c is used for assessing glycaemic control in patients with diabetes. It is also used for treatment goals and as a target for therapeutic intervention. The Direct Control and Complications Trial in the USA showed that HbA1c can be used to predict the risk of complications. Hence, it is important for HbA1c assays to be standardised. The National Glycohemoglobin Standardization Program (NGSP) in the USA was formed in 1996 so that HbA1c results from different laboratories would be comparable to those reported in the DCCT study. There were also HbA1c standardisation programmes in Sweden and Japan. These three standardisation programmes are, in fact, direct comparison methods (DCMs), and yield different HbA1c results. In 1994, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) established a Working Group on Standardisation of HbA1c. This working group has developed a global HbA1c reference system with very much improved intra-assay and inter-assay coefficients of variation. Recommendations have been made to report HbA1c results as IFCC-HbA1c values in SI units (mmol HbA1c/mol Hb) and NGSP-HbA1c (%) as well as estimated average glucose (eAG), once a tight relationship has been shown to exist between eAG and HbA1c.

Authors+Show Affiliations

Gleneagles Intan Medical Centre, Kuala Lumpur, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19291914

Citation

Lai, Leslie C.. "Global Standardisation of HbA1c." The Malaysian Journal of Pathology, vol. 30, no. 2, 2008, pp. 67-71.
Lai LC. Global standardisation of HbA1c. Malays J Pathol. 2008;30(2):67-71.
Lai, L. C. (2008). Global standardisation of HbA1c. The Malaysian Journal of Pathology, 30(2), 67-71.
Lai LC. Global Standardisation of HbA1c. Malays J Pathol. 2008;30(2):67-71. PubMed PMID: 19291914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Global standardisation of HbA1c. A1 - Lai,Leslie C, PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2009/5/1/medline SP - 67 EP - 71 JF - The Malaysian journal of pathology JO - Malays J Pathol VL - 30 IS - 2 N2 - HbA1c is used for assessing glycaemic control in patients with diabetes. It is also used for treatment goals and as a target for therapeutic intervention. The Direct Control and Complications Trial in the USA showed that HbA1c can be used to predict the risk of complications. Hence, it is important for HbA1c assays to be standardised. The National Glycohemoglobin Standardization Program (NGSP) in the USA was formed in 1996 so that HbA1c results from different laboratories would be comparable to those reported in the DCCT study. There were also HbA1c standardisation programmes in Sweden and Japan. These three standardisation programmes are, in fact, direct comparison methods (DCMs), and yield different HbA1c results. In 1994, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) established a Working Group on Standardisation of HbA1c. This working group has developed a global HbA1c reference system with very much improved intra-assay and inter-assay coefficients of variation. Recommendations have been made to report HbA1c results as IFCC-HbA1c values in SI units (mmol HbA1c/mol Hb) and NGSP-HbA1c (%) as well as estimated average glucose (eAG), once a tight relationship has been shown to exist between eAG and HbA1c. SN - 0126-8635 UR - https://www.unboundmedicine.com/medline/citation/19291914/Global_standardisation_of_HbA1c_ L2 - http://www.mjpath.org.my/2008.2/01_Global_standardisation.pdf DB - PRIME DP - Unbound Medicine ER -