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Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran.
Iran J Immunol. 2009 Mar; 6(1):49-54.IJ

Abstract

BACKGROUND

HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups.

OBJECTIVE

The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran).

METHODS

Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP.

RESULTS

Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls.

CONCLUSION

Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies.

Authors+Show Affiliations

Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19293478

Citation

Fouladi, Salomeh, et al. "Distribution of HLA-B*27 Alleles in Patients With Ankylosing Spondylitis in Iran." Iranian Journal of Immunology : IJI, vol. 6, no. 1, 2009, pp. 49-54.
Fouladi S, Adib M, Salehi M, et al. Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. Iran J Immunol. 2009;6(1):49-54.
Fouladi, S., Adib, M., Salehi, M., Karimzadeh, H., Bakhshiani, Z., & Ostadi, V. (2009). Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. Iranian Journal of Immunology : IJI, 6(1), 49-54. https://doi.org/IJIv6i1A6
Fouladi S, et al. Distribution of HLA-B*27 Alleles in Patients With Ankylosing Spondylitis in Iran. Iran J Immunol. 2009;6(1):49-54. PubMed PMID: 19293478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. AU - Fouladi,Salomeh, AU - Adib,Minoo, AU - Salehi,Mansoor, AU - Karimzadeh,Hadi, AU - Bakhshiani,Zahra, AU - Ostadi,Vajiheh, PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2009/7/17/medline SP - 49 EP - 54 JF - Iranian journal of immunology : IJI JO - Iran J Immunol VL - 6 IS - 1 N2 - BACKGROUND: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. OBJECTIVE: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). METHODS: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP. RESULTS: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. CONCLUSION: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies. SN - 1735-1383 UR - https://www.unboundmedicine.com/medline/citation/19293478/Distribution_of_HLA_B_27_alleles_in_patients_with_ankylosing_spondylitis_in_Iran_ L2 - https://iji.sums.ac.ir/?sid=Entrez:PubMed&id=pmid:19293478&key=2009.6.1.49 DB - PRIME DP - Unbound Medicine ER -