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Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran.
Iran J Immunol. 2009 Mar; 6(1):49-54.IJ

Abstract

BACKGROUND

HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups.

OBJECTIVE

The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran).

METHODS

Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP.

RESULTS

Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls.

CONCLUSION

Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies.

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Authors+Show Affiliations

Fouladi S
Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adib M
No affiliation info available
Salehi M
No affiliation info available
Karimzadeh H
No affiliation info available
Bakhshiani Z
No affiliation info available
Ostadi V
No affiliation info available

MeSH

AdolescentAdultAsian Continental Ancestry GroupChildEthnic GroupsEuropean Continental Ancestry GroupGene FrequencyHLA-B AntigensHLA-B27 AntigenHumansIranMiddle AgedSpondylitis, AnkylosingYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19293478

Citation

Fouladi, Salomeh, et al. "Distribution of HLA-B*27 Alleles in Patients With Ankylosing Spondylitis in Iran." Iranian Journal of Immunology : IJI, vol. 6, no. 1, 2009, pp. 49-54.
Fouladi S, Adib M, Salehi M, et al. Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. Iran J Immunol. 2009;6(1):49-54.
Fouladi, S., Adib, M., Salehi, M., Karimzadeh, H., Bakhshiani, Z., & Ostadi, V. (2009). Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. Iranian Journal of Immunology : IJI, 6(1), 49-54. https://doi.org/IJIv6i1A6
Fouladi S, et al. Distribution of HLA-B*27 Alleles in Patients With Ankylosing Spondylitis in Iran. Iran J Immunol. 2009;6(1):49-54. PubMed PMID: 19293478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran. AU - Fouladi,Salomeh, AU - Adib,Minoo, AU - Salehi,Mansoor, AU - Karimzadeh,Hadi, AU - Bakhshiani,Zahra, AU - Ostadi,Vajiheh, PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2009/7/17/medline SP - 49 EP - 54 JF - Iranian journal of immunology : IJI JO - Iran J Immunol VL - 6 IS - 1 N2 - BACKGROUND: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. OBJECTIVE: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). METHODS: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP. RESULTS: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. CONCLUSION: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies. SN - 1735-1383 UR - https://www.unboundmedicine.com/medline/citation/19293478/Distribution_of_HLA_B_27_alleles_in_patients_with_ankylosing_spondylitis_in_Iran_ L2 - https://iji.sums.ac.ir/?sid=Entrez:PubMed&id=pmid:19293478&key=2009.6.1.49 DB - PRIME DP - Unbound Medicine ER -