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The effect of inhaled nitric oxide on the course of extracorporeal membrane oxygenation and the occurrence of hemorrhagic complications.
ASAIO J. 2009 May-Jun; 55(3):213-6.AJ

Abstract

This study evaluated the relation between prior inhaled nitric oxide (iNO) and the time to initiation and duration of treatment with veno-arterial extracorporeal membrane oxygenation (ECMO) and the occurrence of hemorrhagic complications. A retrospective study was conducted in 59 human newborns treated for respiratory insufficiency with ECMO over a 5-year period. Patients received iNO before ECMO (iNO group) or not (control group). Both groups were compared for patient characteristics, postnatal age at the initiation of ECMO, duration of ECMO treatment, and hemorrhagic complications. There were no significant differences between the iNO group and the control group for patient characteristics and medication use before the ECMO treatment, except for norepinephrine. There was no significant difference for postnatal age at the initiation of ECMO and mean duration of ECMO treatment. We found no statistically significant difference in hemorrhagic complications between both groups. This persisted after correction for diagnosis and ECMO run-time in linear logistic regression analysis. Inhaled nitric oxide before ECMO did not result in a significant delay in the initiation of ECMO or longer duration of the ECMO. There was no significant relationship between the use of prior iNO and the occurrence of hemorrhagic complications during the ECMO treatment.

Authors+Show Affiliations

Department of Neonatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.c.demol@cukz.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19293708

Citation

de Mol, Amerik C., et al. "The Effect of Inhaled Nitric Oxide On the Course of Extracorporeal Membrane Oxygenation and the Occurrence of Hemorrhagic Complications." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 55, no. 3, 2009, pp. 213-6.
de Mol AC, van Heijst AF, de Haan TF, et al. The effect of inhaled nitric oxide on the course of extracorporeal membrane oxygenation and the occurrence of hemorrhagic complications. ASAIO J. 2009;55(3):213-6.
de Mol, A. C., van Heijst, A. F., de Haan, T. F., van der Staak, F. H., & Liem, K. D. (2009). The effect of inhaled nitric oxide on the course of extracorporeal membrane oxygenation and the occurrence of hemorrhagic complications. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 55(3), 213-6. https://doi.org/10.1097/MAT.0b013e31819901a5
de Mol AC, et al. The Effect of Inhaled Nitric Oxide On the Course of Extracorporeal Membrane Oxygenation and the Occurrence of Hemorrhagic Complications. ASAIO J. 2009 May-Jun;55(3):213-6. PubMed PMID: 19293708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of inhaled nitric oxide on the course of extracorporeal membrane oxygenation and the occurrence of hemorrhagic complications. AU - de Mol,Amerik C, AU - van Heijst,Arno F J, AU - de Haan,Ton F J, AU - van der Staak,Frans H J M, AU - Liem,Kian D, PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2009/7/17/medline SP - 213 EP - 6 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 55 IS - 3 N2 - This study evaluated the relation between prior inhaled nitric oxide (iNO) and the time to initiation and duration of treatment with veno-arterial extracorporeal membrane oxygenation (ECMO) and the occurrence of hemorrhagic complications. A retrospective study was conducted in 59 human newborns treated for respiratory insufficiency with ECMO over a 5-year period. Patients received iNO before ECMO (iNO group) or not (control group). Both groups were compared for patient characteristics, postnatal age at the initiation of ECMO, duration of ECMO treatment, and hemorrhagic complications. There were no significant differences between the iNO group and the control group for patient characteristics and medication use before the ECMO treatment, except for norepinephrine. There was no significant difference for postnatal age at the initiation of ECMO and mean duration of ECMO treatment. We found no statistically significant difference in hemorrhagic complications between both groups. This persisted after correction for diagnosis and ECMO run-time in linear logistic regression analysis. Inhaled nitric oxide before ECMO did not result in a significant delay in the initiation of ECMO or longer duration of the ECMO. There was no significant relationship between the use of prior iNO and the occurrence of hemorrhagic complications during the ECMO treatment. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/19293708/The_effect_of_inhaled_nitric_oxide_on_the_course_of_extracorporeal_membrane_oxygenation_and_the_occurrence_of_hemorrhagic_complications_ L2 - https://doi.org/10.1097/MAT.0b013e31819901a5 DB - PRIME DP - Unbound Medicine ER -