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Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea.
Eur J Gastroenterol Hepatol 2009; 21(6):606-12EJ

Abstract

OBJECTIVE

This study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up.

METHODS

Serum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined.

RESULTS

Serum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 microg/l, P<0.001; sPGII, 17.5 vs. 8.0 microg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=-0.229, P<0.001), respectively. Men had a higher sPGI (54.7 microg/l) than did women (48.4 microg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis.

CONCLUSION

The H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Bundang-gu, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19293719

Citation

Kim, Hyun Young, et al. "Clinical Meaning of Pepsinogen Test and Helicobacter Pylori Serology in the Health Check-up Population in Korea." European Journal of Gastroenterology & Hepatology, vol. 21, no. 6, 2009, pp. 606-12.
Kim HY, Kim N, Kang JM, et al. Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea. Eur J Gastroenterol Hepatol. 2009;21(6):606-12.
Kim, H. Y., Kim, N., Kang, J. M., Park, Y. S., Lee, D. H., Kim, Y. R., ... Song, I. S. (2009). Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea. European Journal of Gastroenterology & Hepatology, 21(6), pp. 606-12. doi:10.1097/MEG.0b013e3283086757.
Kim HY, et al. Clinical Meaning of Pepsinogen Test and Helicobacter Pylori Serology in the Health Check-up Population in Korea. Eur J Gastroenterol Hepatol. 2009;21(6):606-12. PubMed PMID: 19293719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea. AU - Kim,Hyun Young, AU - Kim,Nayoung, AU - Kang,Jung Mook, AU - Park,Young Soo, AU - Lee,Dong Ho, AU - Kim,Yu Rim, AU - Kim,Joo Sung, AU - Jung,Hyun Chae, AU - Song,In Sung, PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2010/5/21/medline SP - 606 EP - 12 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 21 IS - 6 N2 - OBJECTIVE: This study was performed to assess the affects of age, sex, and Helicobacter pylori status on pepsinogen testing for atrophic gastritis and to establish the clinical implications of pepsinogen test results and H. pylori serology in a Korean population presenting for a health check-up. METHODS: Serum pepsinogen (PG) I and PG II, and H. pylori IgG were measured in 1485 adults. The PG values were analyzed based on age, sex, and H. pylori status, and the cutoff value for atrophic gastritis was determined. RESULTS: Serum PG I (sPGI) and sPGII were higher in H. pylori positive than in H. pylori negative individuals (sPGI, 56.3 vs. 42.2 microg/l, P<0.001; sPGII, 17.5 vs. 8.0 microg/l, P<0.001). The PG I/II ratio was lower in H. pylori positive than in H. pylori negative individuals (3.7 vs. 6.0, P<0.001). The sPGII and PG I/II ratio had a positive (r=0.132, P<0.001) and negative correlation with age (r=-0.229, P<0.001), respectively. Men had a higher sPGI (54.7 microg/l) than did women (48.4 microg/l) (P<0.001) but the PG I/II ratio was not statistically different and neither the atrophic gastritis. The PG I/II cutoff value for atrophic gastritis was 6.0 for H. pylori negative and 3.0 for H. pylori positive individuals. sPGI and sPGII were, however, not specific for atrophic gastritis. CONCLUSION: The H. pylori IgG status, age, and sex were associated with the serum PG levels. To increase the efficacy of the PG I/II ratio for the detection of atrophic gastritis, the cutoff value of the PG I/II ratio should be stratified according to the H. pylori IgG status in the Korean population presenting for a health check-up. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/19293719/Clinical_meaning_of_pepsinogen_test_and_Helicobacter_pylori_serology_in_the_health_check_up_population_in_Korea_ L2 - http://Insights.ovid.com/pubmed?pmid=19293719 DB - PRIME DP - Unbound Medicine ER -