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Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery.
AAPS PharmSciTech 2009; 10(1):289-96AP

Abstract

The purpose of this study was to prepare miconazole nitrate (MN) loaded solid lipid nanoparticles (MN-SLN) effective for topical delivery of miconazole nitrate. Compritol 888 ATO as lipid, propylene glycol (PG) to increase drug solubility in lipid, tween 80, and glyceryl monostearate were used as the surfactants to stabilize SLN dispersion in the SLN preparation using hot homogenization method. SLN dispersions exhibited average size between 244 and 766 nm. All the dispersions had high entrapment efficiency ranging from 80% to 100%. The MN-SLN dispersion which showed good stability for a period of 1 month was selected. This MN-SLN was characterized for particle size, entrapment efficiency, and X-ray diffraction. The penetration of miconazole nitrate from the gel formulated using selected MN-SLN dispersion as into cadaver skins was evaluated ex-vivo using franz diffusion cell. The results of differential scanning calorimetry (DSC) showed that MN was dispersed in SLN in an amorphous state. The MN-SLN formulations could significantly increase the accumulative uptake of MN in skin over the marketed gel and showed a significantly enhanced skin targeting effect. These results indicate that the studied MN-SLN formulation with skin targeting may be a promising carrier for topical delivery of miconazole nitrate.

Authors+Show Affiliations

AISSMS College of Pharmacy, Kennedy Road, Pune, India. mrb1570@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19294517

Citation

Bhalekar, Mangesh R., et al. "Preparation and Evaluation of Miconazole Nitrate-loaded Solid Lipid Nanoparticles for Topical Delivery." AAPS PharmSciTech, vol. 10, no. 1, 2009, pp. 289-96.
Bhalekar MR, Pokharkar V, Madgulkar A, et al. Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AAPS PharmSciTech. 2009;10(1):289-96.
Bhalekar, M. R., Pokharkar, V., Madgulkar, A., Patil, N., & Patil, N. (2009). Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AAPS PharmSciTech, 10(1), pp. 289-96. doi:10.1208/s12249-009-9199-0.
Bhalekar MR, et al. Preparation and Evaluation of Miconazole Nitrate-loaded Solid Lipid Nanoparticles for Topical Delivery. AAPS PharmSciTech. 2009;10(1):289-96. PubMed PMID: 19294517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AU - Bhalekar,Mangesh R, AU - Pokharkar,Varsha, AU - Madgulkar,Ashwini, AU - Patil,Nilam, AU - Patil,Nilkanth, Y1 - 2009/03/18/ PY - 2008/07/25/received PY - 2009/01/14/accepted PY - 2009/3/19/entrez PY - 2009/3/19/pubmed PY - 2009/6/24/medline SP - 289 EP - 96 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 10 IS - 1 N2 - The purpose of this study was to prepare miconazole nitrate (MN) loaded solid lipid nanoparticles (MN-SLN) effective for topical delivery of miconazole nitrate. Compritol 888 ATO as lipid, propylene glycol (PG) to increase drug solubility in lipid, tween 80, and glyceryl monostearate were used as the surfactants to stabilize SLN dispersion in the SLN preparation using hot homogenization method. SLN dispersions exhibited average size between 244 and 766 nm. All the dispersions had high entrapment efficiency ranging from 80% to 100%. The MN-SLN dispersion which showed good stability for a period of 1 month was selected. This MN-SLN was characterized for particle size, entrapment efficiency, and X-ray diffraction. The penetration of miconazole nitrate from the gel formulated using selected MN-SLN dispersion as into cadaver skins was evaluated ex-vivo using franz diffusion cell. The results of differential scanning calorimetry (DSC) showed that MN was dispersed in SLN in an amorphous state. The MN-SLN formulations could significantly increase the accumulative uptake of MN in skin over the marketed gel and showed a significantly enhanced skin targeting effect. These results indicate that the studied MN-SLN formulation with skin targeting may be a promising carrier for topical delivery of miconazole nitrate. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/19294517/Preparation_and_evaluation_of_miconazole_nitrate_loaded_solid_lipid_nanoparticles_for_topical_delivery_ L2 - https://dx.doi.org/10.1208/s12249-009-9199-0 DB - PRIME DP - Unbound Medicine ER -