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Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets.
Ann Nutr Metab. 2009; 54(2):104-10.AN

Abstract

OBJECTIVE

To investigate the influence of the Trp64Arg polymorphism in the beta 3-adrenoreceptor gene on adipocytokines, insulin resistance and weight loss secondary to a low fat versus a low carbohydrate diet.

METHODS

A population of 193 obese patients was analyzed. A nutritional evaluation was performed at the beginning and at the end of a 2-month period in which subjects received 1 of 2 hypocaloric diets.

RESULTS

172 (89.1%; 44 males, 128 females) subjects had the genotype Trp64/Trp64 (wild-type group) and 21 subjects (10.9%; 4 males, 17 females) had Trp64/Arg64 (mutant-type group). In the wild-type group BMI, weight, fat mass, waist circumference, systolic blood pressure, glucose, triglycerides, insulin, homeostasis model assessment (HOMA) and leptin decreased significantly regardless of the diet. In the mutant-type group, this was the case for BMI, weight, waist circumference, fat mass and leptin levels. Only leptin levels have a significant decrease in the wild-type group (diet I 13.7%, diet II 26.3%, p < 0.05 for both). In the mutant group, leptin decreased as well (diet I 22.5%, diet II 30.1%, p < 0.05 for both).

CONCLUSION

The metabolic effect of mild weight reduction by 2 hypocaloric diets is greatest in subjects homozygous for the normal beta 3-adrenoreceptor gene. Improvement in glucose, insulin and HOMA is better than in the mutant-type group.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19295193

Citation

de Luis, D A., et al. "Influence of Trp64Arg Polymorphism of Beta 3-adrenoreceptor Gene On Insulin Resistance, Adipocytokines and Weight Loss Secondary to Two Hypocaloric Diets." Annals of Nutrition & Metabolism, vol. 54, no. 2, 2009, pp. 104-10.
de Luis DA, González Sagrado M, Aller R, et al. Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Ann Nutr Metab. 2009;54(2):104-10.
de Luis, D. A., González Sagrado, M., Aller, R., Izaola, O., & Conde, R. (2009). Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Annals of Nutrition & Metabolism, 54(2), 104-10. https://doi.org/10.1159/000209268
de Luis DA, et al. Influence of Trp64Arg Polymorphism of Beta 3-adrenoreceptor Gene On Insulin Resistance, Adipocytokines and Weight Loss Secondary to Two Hypocaloric Diets. Ann Nutr Metab. 2009;54(2):104-10. PubMed PMID: 19295193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. AU - de Luis,D A, AU - González Sagrado,M, AU - Aller,R, AU - Izaola,O, AU - Conde,R, Y1 - 2009/03/19/ PY - 2008/01/18/received PY - 2009/01/15/accepted PY - 2009/3/20/entrez PY - 2009/3/20/pubmed PY - 2009/6/26/medline SP - 104 EP - 10 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 54 IS - 2 N2 - OBJECTIVE: To investigate the influence of the Trp64Arg polymorphism in the beta 3-adrenoreceptor gene on adipocytokines, insulin resistance and weight loss secondary to a low fat versus a low carbohydrate diet. METHODS: A population of 193 obese patients was analyzed. A nutritional evaluation was performed at the beginning and at the end of a 2-month period in which subjects received 1 of 2 hypocaloric diets. RESULTS: 172 (89.1%; 44 males, 128 females) subjects had the genotype Trp64/Trp64 (wild-type group) and 21 subjects (10.9%; 4 males, 17 females) had Trp64/Arg64 (mutant-type group). In the wild-type group BMI, weight, fat mass, waist circumference, systolic blood pressure, glucose, triglycerides, insulin, homeostasis model assessment (HOMA) and leptin decreased significantly regardless of the diet. In the mutant-type group, this was the case for BMI, weight, waist circumference, fat mass and leptin levels. Only leptin levels have a significant decrease in the wild-type group (diet I 13.7%, diet II 26.3%, p < 0.05 for both). In the mutant group, leptin decreased as well (diet I 22.5%, diet II 30.1%, p < 0.05 for both). CONCLUSION: The metabolic effect of mild weight reduction by 2 hypocaloric diets is greatest in subjects homozygous for the normal beta 3-adrenoreceptor gene. Improvement in glucose, insulin and HOMA is better than in the mutant-type group. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/19295193/Influence_of_Trp64Arg_polymorphism_of_beta_3_adrenoreceptor_gene_on_insulin_resistance_adipocytokines_and_weight_loss_secondary_to_two_hypocaloric_diets_ L2 - https://www.karger.com?DOI=10.1159/000209268 DB - PRIME DP - Unbound Medicine ER -