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Annual incidence and standardized incidence ratio of cerebrovascular accidents in patients with systemic lupus erythematosus.
Scand J Rheumatol 2009; 38(5):362-8SJ

Abstract

OBJECTIVES

To study the annual incidence and standardized incidence ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE).

SUBJECTS AND METHODS

The annual incidence of CVA from 1999 to 2007 in a longitudinal cohort of SLE patients was calculated each year and compared with that of the regional population within the same study period. Age-specific SIRs and outcome of CVA in SLE patients were also studied.

RESULTS

In 2007, there were 490 SLE patients in our cohort. The mean annual incidence of CVA between 1999 and 2007 was 6.45/1000 patients and no obvious trend over time was observed. Of the 20 CVAs in patients with SLE, 18 (90%) were ischaemic stroke whereas two (10%) were haemorrhagic stroke. The mean SIR of all types of CVA in SLE patients was 2.02 [95% confidence interval (CI) 1.30-3.81; p = 0.002]. The SIR of ischaemic stroke decreased with age and the stroke incidence was no longer significantly higher than that of the population in patients aged >or= 60 years. Haemorrhagic stroke occurred mainly in younger SLE patients. The duration of hospitalization and the mortality rate for CVA was non-significantly higher in SLE than in non-SLE patients.

CONCLUSIONS

The incidence of CVA in SLE remained constant over the 8 years between 1999 and 2007. Younger SLE patients are at substantially increased risk of CVA compared to age-matched population. The duration of hospitalization and the mortality rate for CVA are similar in SLE and non-SLE patients.

Authors+Show Affiliations

Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, SAR China. ccmok2005@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19296403

Citation

Mok, C C., et al. "Annual Incidence and Standardized Incidence Ratio of Cerebrovascular Accidents in Patients With Systemic Lupus Erythematosus." Scandinavian Journal of Rheumatology, vol. 38, no. 5, 2009, pp. 362-8.
Mok CC, Ho LY, To CH. Annual incidence and standardized incidence ratio of cerebrovascular accidents in patients with systemic lupus erythematosus. Scand J Rheumatol. 2009;38(5):362-8.
Mok, C. C., Ho, L. Y., & To, C. H. (2009). Annual incidence and standardized incidence ratio of cerebrovascular accidents in patients with systemic lupus erythematosus. Scandinavian Journal of Rheumatology, 38(5), pp. 362-8. doi:10.1080/03009740902776927.
Mok CC, Ho LY, To CH. Annual Incidence and Standardized Incidence Ratio of Cerebrovascular Accidents in Patients With Systemic Lupus Erythematosus. Scand J Rheumatol. 2009;38(5):362-8. PubMed PMID: 19296403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Annual incidence and standardized incidence ratio of cerebrovascular accidents in patients with systemic lupus erythematosus. AU - Mok,C C, AU - Ho,L Y, AU - To,C H, PY - 2009/3/20/entrez PY - 2009/3/20/pubmed PY - 2010/3/3/medline SP - 362 EP - 8 JF - Scandinavian journal of rheumatology JO - Scand. J. Rheumatol. VL - 38 IS - 5 N2 - OBJECTIVES: To study the annual incidence and standardized incidence ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE). SUBJECTS AND METHODS: The annual incidence of CVA from 1999 to 2007 in a longitudinal cohort of SLE patients was calculated each year and compared with that of the regional population within the same study period. Age-specific SIRs and outcome of CVA in SLE patients were also studied. RESULTS: In 2007, there were 490 SLE patients in our cohort. The mean annual incidence of CVA between 1999 and 2007 was 6.45/1000 patients and no obvious trend over time was observed. Of the 20 CVAs in patients with SLE, 18 (90%) were ischaemic stroke whereas two (10%) were haemorrhagic stroke. The mean SIR of all types of CVA in SLE patients was 2.02 [95% confidence interval (CI) 1.30-3.81; p = 0.002]. The SIR of ischaemic stroke decreased with age and the stroke incidence was no longer significantly higher than that of the population in patients aged >or= 60 years. Haemorrhagic stroke occurred mainly in younger SLE patients. The duration of hospitalization and the mortality rate for CVA was non-significantly higher in SLE than in non-SLE patients. CONCLUSIONS: The incidence of CVA in SLE remained constant over the 8 years between 1999 and 2007. Younger SLE patients are at substantially increased risk of CVA compared to age-matched population. The duration of hospitalization and the mortality rate for CVA are similar in SLE and non-SLE patients. SN - 1502-7732 UR - https://www.unboundmedicine.com/medline/citation/19296403/Annual_incidence_and_standardized_incidence_ratio_of_cerebrovascular_accidents_in_patients_with_systemic_lupus_erythematosus_ L2 - http://www.tandfonline.com/doi/full/10.1080/03009740902776927 DB - PRIME DP - Unbound Medicine ER -