Tags

Type your tag names separated by a space and hit enter

Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea.
J Nat Prod. 2009 May 22; 72(5):954-7.JN

Abstract

Four new xanthones, butyraxanthones A-D (1-4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5-10) and a triterpenoid (lupeol). The structures of 1-4 were established by spectroscopic methods. Compounds 1-10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.

Authors+Show Affiliations

UMR 5557 CNRS, Département de Pharmacognosie, Faculté de Pharmacie, Université de Lyon, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19296616

Citation

Zelefack, Fabien, et al. "Cytotoxic and Antiplasmodial Xanthones From Pentadesma Butyracea." Journal of Natural Products, vol. 72, no. 5, 2009, pp. 954-7.
Zelefack F, Guilet D, Fabre N, et al. Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. J Nat Prod. 2009;72(5):954-7.
Zelefack, F., Guilet, D., Fabre, N., Bayet, C., Chevalley, S., Ngouela, S., Lenta, B. N., Valentin, A., Tsamo, E., & Dijoux-Franca, M. G. (2009). Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. Journal of Natural Products, 72(5), 954-7. https://doi.org/10.1021/np8005953
Zelefack F, et al. Cytotoxic and Antiplasmodial Xanthones From Pentadesma Butyracea. J Nat Prod. 2009 May 22;72(5):954-7. PubMed PMID: 19296616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. AU - Zelefack,Fabien, AU - Guilet,David, AU - Fabre,Nicolas, AU - Bayet,Christine, AU - Chevalley,Séverine, AU - Ngouela,Silvère, AU - Lenta,Bruno Ndjakou, AU - Valentin,Alexis, AU - Tsamo,Etienne, AU - Dijoux-Franca,Marie-Geneviève, PY - 2009/3/20/entrez PY - 2009/3/20/pubmed PY - 2010/7/21/medline SP - 954 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 72 IS - 5 N2 - Four new xanthones, butyraxanthones A-D (1-4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5-10) and a triterpenoid (lupeol). The structures of 1-4 were established by spectroscopic methods. Compounds 1-10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19296616/Cytotoxic_and_antiplasmodial_xanthones_from_Pentadesma_butyracea_ L2 - https://doi.org/10.1021/np8005953 DB - PRIME DP - Unbound Medicine ER -