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In vitro and in vivo antifungal activity of essential oils of Cymbopogon martini and Chenopodium ambrosioides and their synergism against dermatophytes.
Mycoses. 2010 Mar 01; 53(2):123-9.M

Abstract

The present study was carried out to evaluate the antifungal efficacy of essential oils (EO) of Cymbopogon martini, Chenopodium ambrosioides and of their combination against dermatophytes and some filamentous fungi in vitro as well as in vivo using a guinea pig model. The minimum inhibitory concentrations of EOs and of their combination were found between 150 and 500 ppm, while those of known antifungal drugs ranged from 1000 to 5500 ppm. EO ointments were prepared and applied against induced ringworm in guinea pig model and disease removal was observed in 7-21 days, and the hair samples showed negative results for fungal culture in a time-dependent manner after the application of EO ointments. Chemical constituents of EOs were determined by GC-MS. Both the EOs and their combination displayed strong antifungal effects. The results provide a scientific validation for the use of these EOs in the treatment of dermatophyte infections and may be recommended as an alternative to synthetic drug for topical application.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Prasad CS
Laboratory of Herbal Pesticides, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi-221005, India.
Shukla R
No affiliation info available
Kumar A
No affiliation info available
Dubey NK
No affiliation info available

MeSH

Administration, TopicalAnimalsAntifungal AgentsArthrodermataceaeChenopodium ambrosioidesCymbopogonDermatomycosesDrug InteractionsDrug Therapy, CombinationGas Chromatography-Mass SpectrometryGuinea PigsMaleMicrobial Sensitivity TestsOils, Volatile

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19298359

Citation

Prasad, Chandra Shekhar, et al. "In Vitro and in Vivo Antifungal Activity of Essential Oils of Cymbopogon Martini and Chenopodium Ambrosioides and Their Synergism Against Dermatophytes." Mycoses, vol. 53, no. 2, 2010, pp. 123-9.
Prasad CS, Shukla R, Kumar A, et al. In vitro and in vivo antifungal activity of essential oils of Cymbopogon martini and Chenopodium ambrosioides and their synergism against dermatophytes. Mycoses. 2010;53(2):123-9.
Prasad, C. S., Shukla, R., Kumar, A., & Dubey, N. K. (2010). In vitro and in vivo antifungal activity of essential oils of Cymbopogon martini and Chenopodium ambrosioides and their synergism against dermatophytes. Mycoses, 53(2), 123-9. https://doi.org/10.1111/j.1439-0507.2008.01676.x
Prasad CS, et al. In Vitro and in Vivo Antifungal Activity of Essential Oils of Cymbopogon Martini and Chenopodium Ambrosioides and Their Synergism Against Dermatophytes. Mycoses. 2010 Mar 1;53(2):123-9. PubMed PMID: 19298359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo antifungal activity of essential oils of Cymbopogon martini and Chenopodium ambrosioides and their synergism against dermatophytes. AU - Prasad,Chandra Shekhar, AU - Shukla,Ravindra, AU - Kumar,Ashok, AU - Dubey,N K, Y1 - 2009/02/26/ PY - 2009/3/21/entrez PY - 2009/3/21/pubmed PY - 2010/8/10/medline SP - 123 EP - 9 JF - Mycoses JO - Mycoses VL - 53 IS - 2 N2 - The present study was carried out to evaluate the antifungal efficacy of essential oils (EO) of Cymbopogon martini, Chenopodium ambrosioides and of their combination against dermatophytes and some filamentous fungi in vitro as well as in vivo using a guinea pig model. The minimum inhibitory concentrations of EOs and of their combination were found between 150 and 500 ppm, while those of known antifungal drugs ranged from 1000 to 5500 ppm. EO ointments were prepared and applied against induced ringworm in guinea pig model and disease removal was observed in 7-21 days, and the hair samples showed negative results for fungal culture in a time-dependent manner after the application of EO ointments. Chemical constituents of EOs were determined by GC-MS. Both the EOs and their combination displayed strong antifungal effects. The results provide a scientific validation for the use of these EOs in the treatment of dermatophyte infections and may be recommended as an alternative to synthetic drug for topical application. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/19298359/In_vitro_and_in_vivo_antifungal_activity_of_essential_oils_of_Cymbopogon_martini_and_Chenopodium_ambrosioides_and_their_synergism_against_dermatophytes_ DB - PRIME DP - Unbound Medicine ER -