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Validation of the Danish Addenbrooke's Cognitive Examination as a screening test in a memory clinic.
Dement Geriatr Cogn Disord. 2009; 27(4):361-5.DG

Abstract

BACKGROUND

Addenbrooke's Cognitive Examination (ACE) is a cognitive screening test developed to detect dementia. It has been validated in several countries. Validation studies have predominantly included patients with various degrees of dementia and healthy controls.

OBJECTIVE

The aim of this study was to evaluate the Danish version of ACE as a screening test for early dementia in an outpatient memory clinic. Further, we wanted to investigate the ability of the ACE to discriminate patients with early Alzheimer's disease (AD) from patients with depression.

METHOD

78 patients with mild AD (MMSE >or=20), 30 non-demented patients diagnosed with depression (originally referred for evaluation of cognitive symptoms), and 63 healthy volunteers, all between 60 and 85 years of age, were included. All patients were given the ACE as a supplement to the standard diagnostic work-up.

RESULTS

The cut-off points for optimal trade-off between sensitivity and specificity for ACE were 85/86 (sensitivity 0.99, specificity 0.94). When these cut-off points were applied to the group of depressive patients, the specificity dropped to 0.64, indicating a great overlap in individual test scores for demented and depressed patients.

CONCLUSION

The optimal cut-off points for ACE found in this Danish study were close to what is reported in most other European studies. The great overlap in ACE scores for demented and depressed patients emphasize that test scores must be interpreted with great caution when used in diagnostic work-up.

Links

Publisher Full Text

Authors+Show Affiliations

Stokholm J
Memory Disorders Research Group, The Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. jette.stokholm@rh.regionh.dk
Vogel A
No affiliation info available
Johannsen P
No affiliation info available
Waldemar G
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseCognition DisordersData Interpretation, StatisticalDenmarkDepressionEducationFemaleHumansLanguageMaleMemoryMemory DisordersMiddle AgedNeuropsychological TestsROC CurveReproducibility of Results

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19299896

Citation

Stokholm, Jette, et al. "Validation of the Danish Addenbrooke's Cognitive Examination as a Screening Test in a Memory Clinic." Dementia and Geriatric Cognitive Disorders, vol. 27, no. 4, 2009, pp. 361-5.
Stokholm J, Vogel A, Johannsen P, et al. Validation of the Danish Addenbrooke's Cognitive Examination as a screening test in a memory clinic. Dement Geriatr Cogn Disord. 2009;27(4):361-5.
Stokholm, J., Vogel, A., Johannsen, P., & Waldemar, G. (2009). Validation of the Danish Addenbrooke's Cognitive Examination as a screening test in a memory clinic. Dementia and Geriatric Cognitive Disorders, 27(4), 361-5. https://doi.org/10.1159/000209271
Stokholm J, et al. Validation of the Danish Addenbrooke's Cognitive Examination as a Screening Test in a Memory Clinic. Dement Geriatr Cogn Disord. 2009;27(4):361-5. PubMed PMID: 19299896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the Danish Addenbrooke's Cognitive Examination as a screening test in a memory clinic. AU - Stokholm,Jette, AU - Vogel,Asmus, AU - Johannsen,Peter, AU - Waldemar,Gunhild, Y1 - 2009/03/20/ PY - 2009/01/16/accepted PY - 2009/3/21/entrez PY - 2009/3/21/pubmed PY - 2009/6/17/medline SP - 361 EP - 5 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 27 IS - 4 N2 - BACKGROUND: Addenbrooke's Cognitive Examination (ACE) is a cognitive screening test developed to detect dementia. It has been validated in several countries. Validation studies have predominantly included patients with various degrees of dementia and healthy controls. OBJECTIVE: The aim of this study was to evaluate the Danish version of ACE as a screening test for early dementia in an outpatient memory clinic. Further, we wanted to investigate the ability of the ACE to discriminate patients with early Alzheimer's disease (AD) from patients with depression. METHOD: 78 patients with mild AD (MMSE >or=20), 30 non-demented patients diagnosed with depression (originally referred for evaluation of cognitive symptoms), and 63 healthy volunteers, all between 60 and 85 years of age, were included. All patients were given the ACE as a supplement to the standard diagnostic work-up. RESULTS: The cut-off points for optimal trade-off between sensitivity and specificity for ACE were 85/86 (sensitivity 0.99, specificity 0.94). When these cut-off points were applied to the group of depressive patients, the specificity dropped to 0.64, indicating a great overlap in individual test scores for demented and depressed patients. CONCLUSION: The optimal cut-off points for ACE found in this Danish study were close to what is reported in most other European studies. The great overlap in ACE scores for demented and depressed patients emphasize that test scores must be interpreted with great caution when used in diagnostic work-up. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19299896/Validation_of_the_Danish_Addenbrooke's_Cognitive_Examination_as_a_screening_test_in_a_memory_clinic_ L2 - https://www.karger.com?DOI=10.1159/000209271 DB - PRIME DP - Unbound Medicine ER -