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HbA1c: how do we measure it and what does it mean?
Curr Opin Endocrinol Diabetes Obes. 2009 Apr; 16(2):113-8.CO

Abstract

PURPOSE OF REVIEW

Description of recent developments in the standardization of HbA1c measurement and interpretation of HbA1c results.

RECENT FINDINGS

HbA1c is extensively used in the management of patients with diabetes. The two major schemes to standardize HbA1c produce values that differ substantially. A prospective, multinational study revealed a linear correlation between HbA1c and average blood glucose. Some, but not all, assay methods are able to accurately measure HbA1c in individuals with common hemoglobin variants.

SUMMARY

Progress in standardization of methods for HbA1c measurement has significantly reduced variation among different methods. The improved accuracy could allow HbA1c to be used for screening and diagnosis of diabetes. A consensus document recommends that HbA1c be reported in both NGSP (%) and IFCC (mmol/mol) units. HbA1c results can be translated into estimated average glucose (eAG), which could be reported in addition to HbA1c.

Authors+Show Affiliations

Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19300091

Citation

Little, Randie R., and David B. Sacks. "HbA1c: How Do We Measure It and what Does It Mean?" Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 16, no. 2, 2009, pp. 113-8.
Little RR, Sacks DB. HbA1c: how do we measure it and what does it mean? Curr Opin Endocrinol Diabetes Obes. 2009;16(2):113-8.
Little, R. R., & Sacks, D. B. (2009). HbA1c: how do we measure it and what does it mean? Current Opinion in Endocrinology, Diabetes, and Obesity, 16(2), 113-8. https://doi.org/10.1097/MED.0b013e328327728d
Little RR, Sacks DB. HbA1c: How Do We Measure It and what Does It Mean. Curr Opin Endocrinol Diabetes Obes. 2009;16(2):113-8. PubMed PMID: 19300091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c: how do we measure it and what does it mean? AU - Little,Randie R, AU - Sacks,David B, PY - 2009/3/21/entrez PY - 2009/3/21/pubmed PY - 2009/5/29/medline SP - 113 EP - 8 JF - Current opinion in endocrinology, diabetes, and obesity JO - Curr Opin Endocrinol Diabetes Obes VL - 16 IS - 2 N2 - PURPOSE OF REVIEW: Description of recent developments in the standardization of HbA1c measurement and interpretation of HbA1c results. RECENT FINDINGS: HbA1c is extensively used in the management of patients with diabetes. The two major schemes to standardize HbA1c produce values that differ substantially. A prospective, multinational study revealed a linear correlation between HbA1c and average blood glucose. Some, but not all, assay methods are able to accurately measure HbA1c in individuals with common hemoglobin variants. SUMMARY: Progress in standardization of methods for HbA1c measurement has significantly reduced variation among different methods. The improved accuracy could allow HbA1c to be used for screening and diagnosis of diabetes. A consensus document recommends that HbA1c be reported in both NGSP (%) and IFCC (mmol/mol) units. HbA1c results can be translated into estimated average glucose (eAG), which could be reported in addition to HbA1c. SN - 1752-2978 UR - https://www.unboundmedicine.com/medline/citation/19300091/HbA1c:_how_do_we_measure_it_and_what_does_it_mean L2 - https://doi.org/10.1097/MED.0b013e328327728d DB - PRIME DP - Unbound Medicine ER -