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The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance.
Am J Hypertens 2009; 22(6):586-92AJ

Abstract

BACKGROUND

Smoking is associated with endothelial dysfunction and increased inflammatory status. The amino acid L-arginine, improves endothelial function in patients with cardiovascular risk factors. We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking.

METHODS

We studied the effect of L-arginine and/or placebo in 12 healthy young smokers on three occasions (day 0, day 1, and day 3). The study was carried out on two separate arms, one with L-arginine (3 x 7 g/day) and one with placebo, according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before, immediately after, and 20 min after cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) and as a measure of arterial wave reflections. Serum soluble intercellular adhesion molecule-1 (sICAM-1) was measured.

RESULTS

Compared to placebo, L-arginine improved FMD (P < 0.01 at day 1 and P < 0.05 at day 3). L-Arginine reduced PWV and AIx at both days 1 and 3 (P < 0.05 vs. baseline). L-Arginine blunted the acute smoking-induced increase of AIx at both day 1 (P < 0.05) and day 3 (P < 0.01), and prevented the smoking-induced elevation of PWV at day 3 (P < 0.05). Importantly, L-arginine reduced sICAM-1 at days 1 and 3 (P < 0.05 for both vs. baseline).

CONCLUSIONS

Oral L-arginine improves endothelial function and vascular elastic properties of the arterial tree during the acute phase of smoking, an effect accompanied by reduced sICAM-1 levels in these subjects.

Authors+Show Affiliations

Department of Biological Chemistry, Athens University Medical School, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19300425

Citation

Siasos, Gerasimos, et al. "The Impact of Oral L-arginine Supplementation On Acute Smoking-induced Endothelial Injury and Arterial Performance." American Journal of Hypertension, vol. 22, no. 6, 2009, pp. 586-92.
Siasos G, Tousoulis D, Vlachopoulos C, et al. The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. Am J Hypertens. 2009;22(6):586-92.
Siasos, G., Tousoulis, D., Vlachopoulos, C., Antoniades, C., Stefanadi, E., Ioakeimidis, N., ... Stefanadis, C. (2009). The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. American Journal of Hypertension, 22(6), pp. 586-92. doi:10.1038/ajh.2009.57.
Siasos G, et al. The Impact of Oral L-arginine Supplementation On Acute Smoking-induced Endothelial Injury and Arterial Performance. Am J Hypertens. 2009;22(6):586-92. PubMed PMID: 19300425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. AU - Siasos,Gerasimos, AU - Tousoulis,Dimitris, AU - Vlachopoulos,Charalambos, AU - Antoniades,Charalambos, AU - Stefanadi,Elli, AU - Ioakeimidis,Nikos, AU - Zisimos,Kostas, AU - Siasou,Zoi, AU - Papavassiliou,Athanasios G, AU - Stefanadis,Christodoulos, Y1 - 2009/03/19/ PY - 2009/3/21/entrez PY - 2009/3/21/pubmed PY - 2009/6/24/medline SP - 586 EP - 92 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 22 IS - 6 N2 - BACKGROUND: Smoking is associated with endothelial dysfunction and increased inflammatory status. The amino acid L-arginine, improves endothelial function in patients with cardiovascular risk factors. We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking. METHODS: We studied the effect of L-arginine and/or placebo in 12 healthy young smokers on three occasions (day 0, day 1, and day 3). The study was carried out on two separate arms, one with L-arginine (3 x 7 g/day) and one with placebo, according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before, immediately after, and 20 min after cigarette smoking. Endothelial function was evaluated by flow-mediated dilation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) and as a measure of arterial wave reflections. Serum soluble intercellular adhesion molecule-1 (sICAM-1) was measured. RESULTS: Compared to placebo, L-arginine improved FMD (P < 0.01 at day 1 and P < 0.05 at day 3). L-Arginine reduced PWV and AIx at both days 1 and 3 (P < 0.05 vs. baseline). L-Arginine blunted the acute smoking-induced increase of AIx at both day 1 (P < 0.05) and day 3 (P < 0.01), and prevented the smoking-induced elevation of PWV at day 3 (P < 0.05). Importantly, L-arginine reduced sICAM-1 at days 1 and 3 (P < 0.05 for both vs. baseline). CONCLUSIONS: Oral L-arginine improves endothelial function and vascular elastic properties of the arterial tree during the acute phase of smoking, an effect accompanied by reduced sICAM-1 levels in these subjects. SN - 1941-7225 UR - https://www.unboundmedicine.com/medline/citation/19300425/The_impact_of_oral_L_arginine_supplementation_on_acute_smoking_induced_endothelial_injury_and_arterial_performance_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1038/ajh.2009.57 DB - PRIME DP - Unbound Medicine ER -