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Small bowel responses to enteral honey and glutamine administration following massive small bowel resection in rabbit.

Abstract

The trophic effects of honey and glutamine in the healing and adaptation of the small bowel following intestinal resection were studied in some Nigerian non-descript breeds of rabbits. Nine rabbits of mixed sexes with mean body weight of 1.45 +/- 0.55 kg were used. They were randomised into three treatment groups following 50% small bowel resection. Group A rabbits were placed on oral honey treatment, Group B on oral glutamine and group C on normal saline (control). All groups exhibited signs of small bowel adaptation (glutamine(B) honey (A) control (C) at the end of the experiment (4 weeks) with oral glutamine showing the best overall effects on intestinal mucosal growth and adaptation evidenced by significant increase (P<0.05) in residual bowel length (37.3%), villi width (20.0%), crypt depth (113.3%) and a non significant increase in villus height (33.3%) and cellular mass (10.2%). Honey showed a better effect than control with a significant increase (P<0.05) in villi width (18.2%), crypts depth (66.7%) and cellular mass (33.9%) and a non significant increase in gross residual bowel length (24.6%), and villus height (30.5%). Our result shows that honey and glutamine have trophic effects on bowel mucosa healing and hyperplasia and have potential therapeutic effects on massive bowel resection in humans.

Authors+Show Affiliations

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Department of Veterinary Surgery and Reproduction, University of Ibadan, Ibadan, Oyo State, Nigeria. eyarefe@hotmail.com

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Source

MeSH

Analysis of Variance
Animals
Digestive System Surgical Procedures
Enteral Nutrition
Female
Glucose
Glutamine
Honey
Intestinal Mucosa
Intestine, Small
Male
Rabbits
Random Allocation
Wound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19301706

Citation

TY - JOUR T1 - Small bowel responses to enteral honey and glutamine administration following massive small bowel resection in rabbit. AU - Eyarefe,O D, AU - Emikpe,B O, AU - Arowolo,O A, PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/4/1/medline SP - 309 EP - 14 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 37 IS - 4 N2 - The trophic effects of honey and glutamine in the healing and adaptation of the small bowel following intestinal resection were studied in some Nigerian non-descript breeds of rabbits. Nine rabbits of mixed sexes with mean body weight of 1.45 +/- 0.55 kg were used. They were randomised into three treatment groups following 50% small bowel resection. Group A rabbits were placed on oral honey treatment, Group B on oral glutamine and group C on normal saline (control). All groups exhibited signs of small bowel adaptation (glutamine(B) honey (A) control (C) at the end of the experiment (4 weeks) with oral glutamine showing the best overall effects on intestinal mucosal growth and adaptation evidenced by significant increase (P<0.05) in residual bowel length (37.3%), villi width (20.0%), crypt depth (113.3%) and a non significant increase in villus height (33.3%) and cellular mass (10.2%). Honey showed a better effect than control with a significant increase (P<0.05) in villi width (18.2%), crypts depth (66.7%) and cellular mass (33.9%) and a non significant increase in gross residual bowel length (24.6%), and villus height (30.5%). Our result shows that honey and glutamine have trophic effects on bowel mucosa healing and hyperplasia and have potential therapeutic effects on massive bowel resection in humans. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/19301706/full_citation/Small_bowel_responses_to_enteral_honey_and_glutamine_administration_following_massive_small_bowel_resection_in_rabbit_ L2 - http://www.scholaruniverse.com/ncbi-linkout?id=19301706 ER -