Tags

Type your tag names separated by a space and hit enter

Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine HCl, a potent ligand for intracellular histamine receptors.
Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1297-304.BB

Abstract

We have implicated histamine as a mediator of proliferation through its binding to novel intracellular receptors (HIC), closely associated with antiestrogen binding sites (AEBS) in microsomes and nuclei. N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE), is a potent ligand for AEBS/HIC. We now demonstrate that DPPE stimulates in vivo tumor growth (DMBA-induced mammary cancer in Sprague-Dawley rats and L5178Y leukemia in DBA/2 mice) and synergizes with phorbol-12-myristate-13-acetate (PMA) to induce inflammation and mitotic activity in mouse epidermis. Thus, ligands for intracellular histamine receptors may represent a new class of tumor promoting agents; this finding lends new credence to an important role for histamine in growth.

Authors+Show Affiliations

Brandes LJ
Department of Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Beecroft WA
No affiliation info available
Hogg GR
No affiliation info available

MeSH

9,10-Dimethyl-1,2-benzanthraceneAnimalsCell DivisionDrug SynergismEpitheliumFemaleHistamine AntagonistsHyperplasiaInflammationLeukemia L5178MaleMammary Neoplasms, ExperimentalMiceMice, Inbred DBAMitotic IndexPhenyl EthersRatsRats, Inbred StrainsReceptors, HistamineSkinTetradecanoylphorbol Acetate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1930176

Citation

Brandes, L J., et al. "Stimulation of in Vivo Tumor Growth and Phorbol Ester-induced Inflammation By N,N-diethyl-2-[4-(phenylmethyl)phenoxy] Ethanamine HCl, a Potent Ligand for Intracellular Histamine Receptors." Biochemical and Biophysical Research Communications, vol. 179, no. 3, 1991, pp. 1297-304.
Brandes LJ, Beecroft WA, Hogg GR. Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine HCl, a potent ligand for intracellular histamine receptors. Biochem Biophys Res Commun. 1991;179(3):1297-304.
Brandes, L. J., Beecroft, W. A., & Hogg, G. R. (1991). Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine HCl, a potent ligand for intracellular histamine receptors. Biochemical and Biophysical Research Communications, 179(3), 1297-304.
Brandes LJ, Beecroft WA, Hogg GR. Stimulation of in Vivo Tumor Growth and Phorbol Ester-induced Inflammation By N,N-diethyl-2-[4-(phenylmethyl)phenoxy] Ethanamine HCl, a Potent Ligand for Intracellular Histamine Receptors. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1297-304. PubMed PMID: 1930176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine HCl, a potent ligand for intracellular histamine receptors. AU - Brandes,L J, AU - Beecroft,W A, AU - Hogg,G R, PY - 1991/9/30/pubmed PY - 1991/9/30/medline PY - 1991/9/30/entrez SP - 1297 EP - 304 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 179 IS - 3 N2 - We have implicated histamine as a mediator of proliferation through its binding to novel intracellular receptors (HIC), closely associated with antiestrogen binding sites (AEBS) in microsomes and nuclei. N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE), is a potent ligand for AEBS/HIC. We now demonstrate that DPPE stimulates in vivo tumor growth (DMBA-induced mammary cancer in Sprague-Dawley rats and L5178Y leukemia in DBA/2 mice) and synergizes with phorbol-12-myristate-13-acetate (PMA) to induce inflammation and mitotic activity in mouse epidermis. Thus, ligands for intracellular histamine receptors may represent a new class of tumor promoting agents; this finding lends new credence to an important role for histamine in growth. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/1930176/Stimulation_of_in_vivo_tumor_growth_and_phorbol_ester_induced_inflammation_by_NN_diethyl_2_[4__phenylmethyl_phenoxy]_ethanamine_HCl_a_potent_ligand_for_intracellular_histamine_receptors_ DB - PRIME DP - Unbound Medicine ER -