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Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30; 33(3):435-49.PN

Abstract

Serotonergic receptors take their physiologic effects by affecting adenylyl cyclase (AC) catalytic activity and cyclic adenosine monophosphate (cAMP) concentration. AC-cAMP second messenger pathway has been recently suggested to play an important role in depression. Therefore, the compound that regulates the signal pathway may have potential as antidepressant. Curcumin is the main component of Curcuma longa L, a well-known indigenous herb with comprehensive bioactivities. In the present study, we investigated the effects of chronic unpredictable mild stress (CUMS) and curcumin on behaviours and serotonergic receptor-coupled AC-cAMP signal pathway in rats. Curcumin produced beneficial effects on the stressed rats by effectively improving CUMS-induced low sucrose consumption and reducing serum corticosterone levels in rats. Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats. Curcumin also attenuated CUMS-induced reductions of 5-hydroxytryptamine (5-HT) levels and high expressions of central 5-HT(1A/1B/7) receptors in rats. These results suggested that the potent antidepressant property of curcumin might be attributed to its improvement of AC-cAMP pathway as well as CREB via suppressing central 5-HT(1A/1B/7) receptors in the CUMS rats. Our findings provided a basis for examining the interaction of serotonergic receptors and AC-cAMP pathway in depression and curcumin treatment.

Authors+Show Affiliations

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19302828

Citation

Li, Yu-Cheng, et al. "Antidepressant-like Effects of Curcumin On Serotonergic Receptor-coupled AC-cAMP Pathway in Chronic Unpredictable Mild Stress of Rats." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 33, no. 3, 2009, pp. 435-49.
Li YC, Wang FM, Pan Y, et al. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(3):435-49.
Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., & Kong, L. D. (2009). Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Progress in Neuro-psychopharmacology & Biological Psychiatry, 33(3), 435-49. https://doi.org/10.1016/j.pnpbp.2009.01.006
Li YC, et al. Antidepressant-like Effects of Curcumin On Serotonergic Receptor-coupled AC-cAMP Pathway in Chronic Unpredictable Mild Stress of Rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):435-49. PubMed PMID: 19302828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. AU - Li,Yu-Cheng, AU - Wang,Fu-Meng, AU - Pan,Ying, AU - Qiang,Li-Qin, AU - Cheng,Guang, AU - Zhang,Wei-Yun, AU - Kong,Ling-Dong, Y1 - 2009/01/22/ PY - 2008/09/15/received PY - 2009/01/01/revised PY - 2009/01/07/accepted PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/6/17/medline SP - 435 EP - 49 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 33 IS - 3 N2 - Serotonergic receptors take their physiologic effects by affecting adenylyl cyclase (AC) catalytic activity and cyclic adenosine monophosphate (cAMP) concentration. AC-cAMP second messenger pathway has been recently suggested to play an important role in depression. Therefore, the compound that regulates the signal pathway may have potential as antidepressant. Curcumin is the main component of Curcuma longa L, a well-known indigenous herb with comprehensive bioactivities. In the present study, we investigated the effects of chronic unpredictable mild stress (CUMS) and curcumin on behaviours and serotonergic receptor-coupled AC-cAMP signal pathway in rats. Curcumin produced beneficial effects on the stressed rats by effectively improving CUMS-induced low sucrose consumption and reducing serum corticosterone levels in rats. Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats. Curcumin also attenuated CUMS-induced reductions of 5-hydroxytryptamine (5-HT) levels and high expressions of central 5-HT(1A/1B/7) receptors in rats. These results suggested that the potent antidepressant property of curcumin might be attributed to its improvement of AC-cAMP pathway as well as CREB via suppressing central 5-HT(1A/1B/7) receptors in the CUMS rats. Our findings provided a basis for examining the interaction of serotonergic receptors and AC-cAMP pathway in depression and curcumin treatment. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/19302828/Antidepressant_like_effects_of_curcumin_on_serotonergic_receptor_coupled_AC_cAMP_pathway_in_chronic_unpredictable_mild_stress_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(09)00007-4 DB - PRIME DP - Unbound Medicine ER -