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Intrathecal baclofen infusion for ambulant children with cerebral palsy.
Pediatr Neurol. 2009 Apr; 40(4):265-70.PN

Abstract

This study assessed the effects of continuous intrathecal infusion of baclofen on the gait of ambulant children with cerebral palsy. Details, collected retrospectively before and after pump implantation, included Gillette Functional Assessment Questionnaire score, use of walking aids, Ashworth Scale score, and joint angle at which the stretch reflex was triggered. Twenty-one ambulant children and young adults with cerebral palsy were included. Their mean age was 11 years and 10 months (standard deviation, 4 years and 10 months; range, 6-22 years). The mean length of treatment was 25.8 months (range, 5-75 months). After treatment, the lower-limb Ashworth score decreased by 1.4 points (standard deviation, 0.52), and the Gillette Functional Assessment Questionnaire score increased significantly, from 5.04 (standard deviation, 2.08) to 6.09 (standard deviation, 2.05) (P < 0.05). Seven children were able to use less supportive walking aids. Continuous intrathecal baclofen infusion appears to decrease spasticity and improve the gait capacity of children with cerebral palsy. Prospective, controlled studies are necessary to prove the functional effect of intrathecal baclofen infusion.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Centre Hospitalo-Universitaire Morvan, Brest, France. sylvain.brochard@chu-brest.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

19302938

Citation

Brochard, Sylvain, et al. "Intrathecal Baclofen Infusion for Ambulant Children With Cerebral Palsy." Pediatric Neurology, vol. 40, no. 4, 2009, pp. 265-70.
Brochard S, Remy-Neris O, Filipetti P, et al. Intrathecal baclofen infusion for ambulant children with cerebral palsy. Pediatr Neurol. 2009;40(4):265-70.
Brochard, S., Remy-Neris, O., Filipetti, P., & Bussel, B. (2009). Intrathecal baclofen infusion for ambulant children with cerebral palsy. Pediatric Neurology, 40(4), 265-70. https://doi.org/10.1016/j.pediatrneurol.2008.10.020
Brochard S, et al. Intrathecal Baclofen Infusion for Ambulant Children With Cerebral Palsy. Pediatr Neurol. 2009;40(4):265-70. PubMed PMID: 19302938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrathecal baclofen infusion for ambulant children with cerebral palsy. AU - Brochard,Sylvain, AU - Remy-Neris,Olivier, AU - Filipetti,Paul, AU - Bussel,Bernard, PY - 2008/05/28/received PY - 2008/09/15/revised PY - 2008/10/30/accepted PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/5/23/medline SP - 265 EP - 70 JF - Pediatric neurology JO - Pediatr. Neurol. VL - 40 IS - 4 N2 - This study assessed the effects of continuous intrathecal infusion of baclofen on the gait of ambulant children with cerebral palsy. Details, collected retrospectively before and after pump implantation, included Gillette Functional Assessment Questionnaire score, use of walking aids, Ashworth Scale score, and joint angle at which the stretch reflex was triggered. Twenty-one ambulant children and young adults with cerebral palsy were included. Their mean age was 11 years and 10 months (standard deviation, 4 years and 10 months; range, 6-22 years). The mean length of treatment was 25.8 months (range, 5-75 months). After treatment, the lower-limb Ashworth score decreased by 1.4 points (standard deviation, 0.52), and the Gillette Functional Assessment Questionnaire score increased significantly, from 5.04 (standard deviation, 2.08) to 6.09 (standard deviation, 2.05) (P < 0.05). Seven children were able to use less supportive walking aids. Continuous intrathecal baclofen infusion appears to decrease spasticity and improve the gait capacity of children with cerebral palsy. Prospective, controlled studies are necessary to prove the functional effect of intrathecal baclofen infusion. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/19302938/Intrathecal_baclofen_infusion_for_ambulant_children_with_cerebral_palsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(08)00569-9 DB - PRIME DP - Unbound Medicine ER -