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Quantitative assessment of red meat or processed meat consumption and kidney cancer.

Abstract

OBJECTIVE

To conduct a quantitative assessment of red meat or processed meat consumption and kidney cancer.

METHODS

We extracted data from 12 case-control studies, three cohort studies, and the Pooling Project of Diet and Cancer publication for which 13 international cohorts were evaluated. Random effects meta-analysis models were used to calculate summary relative risk estimates (SRRE) based on high vs. low intake values. Sensitivity and influence analyses were conducted, including assessments of heterogeneity.

RESULTS

The SRRE for all studies that reported results for red meat (included variables labeled 'red meat' or single red meat items, such as beef, pork, or liver) was 1.12 (95% CI: 0.98-1.29; p-value for heterogeneity=0.015), and the SRRE using only data from prospective cohorts was 1.02 (95% CI: 0.91-1.15) with minimal heterogeneity (p=0.741). Similarly, in a meta-analysis of the five studies that simultaneously adjusted for smoking, BMI, and total energy intake, the SRRE for red meat was 1.02 (95% CI: 0.91-1.15). No significant association was observed in the meta-analysis of processed meat consumption (SRRE=1.07; 95% CI: 0.94-1.23), although a significant association was observed when only data from cohort studies were analyzed (SRRE=1.19; 95% CI: 1.03-1.37).

CONCLUSIONS

Although many of the summary results were positive, all were weak in magnitude, most were not statistically significant, and associations were attenuated among studies that adjusted for key potential confounding factors. In summary, the findings of this meta-analysis are not supportive of an independent relation between red or processed meat intake and kidney cancer.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Exponent Health Sciences, 185 Hansen Court, Suite 100, Wood Dale, IL 60191, USA. dalexander@exponent.com

    Source

    Cancer detection and prevention 32:5-6 2009 pg 340-51

    MeSH

    Animals
    Case-Control Studies
    Cattle
    Cohort Studies
    Humans
    Kidney Neoplasms
    Meat
    Meat Products
    Risk Assessment
    Risk Factors
    Swine

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19303221

    Citation

    Alexander, Dominik D., and Colleen A. Cushing. "Quantitative Assessment of Red Meat or Processed Meat Consumption and Kidney Cancer." Cancer Detection and Prevention, vol. 32, no. 5-6, 2009, pp. 340-51.
    Alexander DD, Cushing CA. Quantitative assessment of red meat or processed meat consumption and kidney cancer. Cancer Detect Prev. 2009;32(5-6):340-51.
    Alexander, D. D., & Cushing, C. A. (2009). Quantitative assessment of red meat or processed meat consumption and kidney cancer. Cancer Detection and Prevention, 32(5-6), pp. 340-51. doi:10.1016/j.cdp.2009.02.002.
    Alexander DD, Cushing CA. Quantitative Assessment of Red Meat or Processed Meat Consumption and Kidney Cancer. Cancer Detect Prev. 2009;32(5-6):340-51. PubMed PMID: 19303221.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Quantitative assessment of red meat or processed meat consumption and kidney cancer. AU - Alexander,Dominik D, AU - Cushing,Colleen A, Y1 - 2009/03/19/ PY - 2008/11/06/received PY - 2009/01/06/revised PY - 2009/02/06/accepted PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/8/21/medline SP - 340 EP - 51 JF - Cancer detection and prevention JO - Cancer Detect. Prev. VL - 32 IS - 5-6 N2 - OBJECTIVE: To conduct a quantitative assessment of red meat or processed meat consumption and kidney cancer. METHODS: We extracted data from 12 case-control studies, three cohort studies, and the Pooling Project of Diet and Cancer publication for which 13 international cohorts were evaluated. Random effects meta-analysis models were used to calculate summary relative risk estimates (SRRE) based on high vs. low intake values. Sensitivity and influence analyses were conducted, including assessments of heterogeneity. RESULTS: The SRRE for all studies that reported results for red meat (included variables labeled 'red meat' or single red meat items, such as beef, pork, or liver) was 1.12 (95% CI: 0.98-1.29; p-value for heterogeneity=0.015), and the SRRE using only data from prospective cohorts was 1.02 (95% CI: 0.91-1.15) with minimal heterogeneity (p=0.741). Similarly, in a meta-analysis of the five studies that simultaneously adjusted for smoking, BMI, and total energy intake, the SRRE for red meat was 1.02 (95% CI: 0.91-1.15). No significant association was observed in the meta-analysis of processed meat consumption (SRRE=1.07; 95% CI: 0.94-1.23), although a significant association was observed when only data from cohort studies were analyzed (SRRE=1.19; 95% CI: 1.03-1.37). CONCLUSIONS: Although many of the summary results were positive, all were weak in magnitude, most were not statistically significant, and associations were attenuated among studies that adjusted for key potential confounding factors. In summary, the findings of this meta-analysis are not supportive of an independent relation between red or processed meat intake and kidney cancer. SN - 1525-1500 UR - https://www.unboundmedicine.com/medline/citation/19303221/Quantitative_assessment_of_red_meat_or_processed_meat_consumption_and_kidney_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-090X(09)00014-2 DB - PRIME DP - Unbound Medicine ER -