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Oxidized phospholipids in control of inflammation and endothelial barrier.
Transl Res. 2009 Apr; 153(4):166-76.TR

Abstract

The levels of circulating oxidized phospholipids (OxPLs) become increased in chronic and acute pathologic conditions such as hyperlipidemia, atherosclerosis, increased intimamedia thickness in the patients with systemic Lupus erythematosus, vascular balloon injury, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). These pathologies are associated with inflammation and activation of endothelial cells. Depending on the biological context and the specific group of phospholipid oxidation products, OxPL may exhibit both proinflammatory and anti-inflammatory effects. This review will summarize the data showing a dual role of OxPL in modulation of chronic and acute inflammation as well as OxPL effects on pulmonary endothelial permeability. Recent reports show protective effects of OxPL in the models of endotoxin and ventilator-induced ALI and suggest a potential for using OxPL-derived cyclopenthenone-containing compounds with barrier-protective properties for drug design. These compounds may represent a new group of therapeutic agents for the treatment of lung syndromes associated with acute inflammation and lung vascular leak.

Authors+Show Affiliations

Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill 60637, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

19304275

Citation

Fu, Panfeng, and Konstantin G. Birukov. "Oxidized Phospholipids in Control of Inflammation and Endothelial Barrier." Translational Research : the Journal of Laboratory and Clinical Medicine, vol. 153, no. 4, 2009, pp. 166-76.
Fu P, Birukov KG. Oxidized phospholipids in control of inflammation and endothelial barrier. Transl Res. 2009;153(4):166-76.
Fu, P., & Birukov, K. G. (2009). Oxidized phospholipids in control of inflammation and endothelial barrier. Translational Research : the Journal of Laboratory and Clinical Medicine, 153(4), 166-76. https://doi.org/10.1016/j.trsl.2008.12.005
Fu P, Birukov KG. Oxidized Phospholipids in Control of Inflammation and Endothelial Barrier. Transl Res. 2009;153(4):166-76. PubMed PMID: 19304275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized phospholipids in control of inflammation and endothelial barrier. AU - Fu,Panfeng, AU - Birukov,Konstantin G, Y1 - 2009/01/21/ PY - 2008/10/03/received PY - 2008/12/15/revised PY - 2008/12/16/accepted PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/5/20/medline SP - 166 EP - 76 JF - Translational research : the journal of laboratory and clinical medicine JO - Transl Res VL - 153 IS - 4 N2 - The levels of circulating oxidized phospholipids (OxPLs) become increased in chronic and acute pathologic conditions such as hyperlipidemia, atherosclerosis, increased intimamedia thickness in the patients with systemic Lupus erythematosus, vascular balloon injury, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). These pathologies are associated with inflammation and activation of endothelial cells. Depending on the biological context and the specific group of phospholipid oxidation products, OxPL may exhibit both proinflammatory and anti-inflammatory effects. This review will summarize the data showing a dual role of OxPL in modulation of chronic and acute inflammation as well as OxPL effects on pulmonary endothelial permeability. Recent reports show protective effects of OxPL in the models of endotoxin and ventilator-induced ALI and suggest a potential for using OxPL-derived cyclopenthenone-containing compounds with barrier-protective properties for drug design. These compounds may represent a new group of therapeutic agents for the treatment of lung syndromes associated with acute inflammation and lung vascular leak. SN - 1931-5244 UR - https://www.unboundmedicine.com/medline/citation/19304275/Oxidized_phospholipids_in_control_of_inflammation_and_endothelial_barrier_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1931-5244(08)00337-X DB - PRIME DP - Unbound Medicine ER -