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Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions.
Acta Pharm. 2009 Mar; 59(1):57-65.AP

Abstract

The objective of the present investigation was to study the effect of polyethylene glycol 4000 (PEG 4000) on in vitro dissolution of gliclazide from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the melting or fusion method.Phase and saturation solubility study, in vitro dissolution of pure drug, physical mixtures and solid dispersions were carried out. PEG was found to be effective in increasing the dissolution of gliclazide in solid dispersions when compared to pure drug. FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry studies were carried out in order to characterize the drug in the physical mixtures and solid dispersions. Dissolution enhancement was attributed to decreased crystallinity of the drug and to the wetting and solubilizing effect of the carrier from the solid dispersions of gliclazide. In conclusion, dissolution of gliclazide can be enhanced by the use of hydrophilic carrier.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440033, India. morupatil@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19304558

Citation

Patil, Moreshwar P., and Naresh J. Gaikwad. "Preparation and Characterization of Gliclazide-polyethylene Glycol 4000 Solid Dispersions." Acta Pharmaceutica (Zagreb, Croatia), vol. 59, no. 1, 2009, pp. 57-65.
Patil MP, Gaikwad NJ. Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions. Acta Pharm. 2009;59(1):57-65.
Patil, M. P., & Gaikwad, N. J. (2009). Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions. Acta Pharmaceutica (Zagreb, Croatia), 59(1), 57-65. https://doi.org/10.2478/v10007-009-0001-3
Patil MP, Gaikwad NJ. Preparation and Characterization of Gliclazide-polyethylene Glycol 4000 Solid Dispersions. Acta Pharm. 2009;59(1):57-65. PubMed PMID: 19304558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of gliclazide-polyethylene glycol 4000 solid dispersions. AU - Patil,Moreshwar P, AU - Gaikwad,Naresh J, PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/5/14/medline SP - 57 EP - 65 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 59 IS - 1 N2 - The objective of the present investigation was to study the effect of polyethylene glycol 4000 (PEG 4000) on in vitro dissolution of gliclazide from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the melting or fusion method.Phase and saturation solubility study, in vitro dissolution of pure drug, physical mixtures and solid dispersions were carried out. PEG was found to be effective in increasing the dissolution of gliclazide in solid dispersions when compared to pure drug. FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry studies were carried out in order to characterize the drug in the physical mixtures and solid dispersions. Dissolution enhancement was attributed to decreased crystallinity of the drug and to the wetting and solubilizing effect of the carrier from the solid dispersions of gliclazide. In conclusion, dissolution of gliclazide can be enhanced by the use of hydrophilic carrier. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/19304558/Preparation_and_characterization_of_gliclazide_polyethylene_glycol_4000_solid_dispersions_ L2 - https://www.degruyter.com/document/doi/10.2478/v10007-009-0001-3 DB - PRIME DP - Unbound Medicine ER -