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Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men.
Eur Heart J. 2009 May; 30(9):1113-20.EH

Abstract

AIMS

Obesity is a recognized risk factor for atrial fibrillation (AF), partly because of the association between body mass index (BMI) and atrial volume. We aimed to determine whether other factors relating to body size were related to AF.

METHODS AND RESULTS

Data were derived from a random population sample of 6903 men (mean age 51.5 years) who underwent a single midlife evaluation as part of the multifactor Swedish Primary Prevention Study. A total of 1253 men (18.2%) had a subsequent hospital discharge diagnosis (principal or secondary) of AF during a maximum follow-up of 34.3 years. Body surface area (BSA) at age 20 (calculated from recalled weight and measured height) was strongly related to subsequent AF (P < 0.0001), as were midlife BMI and weight gain from age 20 to midlife (P < 0.0001). In a Cox regression model which adjusted for midlife BMI, weight gain and other risk factors, hazard ratios (HR) [95% confidence intervals (CI)] for AF for the second, third, and fourth quartile of BSA at age 20, compared with the lowest quartile, were 1.47 (95% CI, 1.22-1.76), 1.66 (95% CI, 1.38-2.00), and 2.22 (95% CI, 1.82-2.70) (P for trend <0.0001).

CONCLUSION

Large body size in youth, in an era when obesity was rare, as well as weight gain from age 20 to midlife, were both independently related to the development of AF. Given the current trends not only for obesity but also for height, a substantial increase in the incidence of AF is likely.

Authors+Show Affiliations

Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg SE-416 85, Sweden. annika.rosengren@gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19304990

Citation

Rosengren, Annika, et al. "Big Men and Atrial Fibrillation: Effects of Body Size and Weight Gain On Risk of Atrial Fibrillation in Men." European Heart Journal, vol. 30, no. 9, 2009, pp. 1113-20.
Rosengren A, Hauptman PJ, Lappas G, et al. Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. Eur Heart J. 2009;30(9):1113-20.
Rosengren, A., Hauptman, P. J., Lappas, G., Olsson, L., Wilhelmsen, L., & Swedberg, K. (2009). Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. European Heart Journal, 30(9), 1113-20. https://doi.org/10.1093/eurheartj/ehp076
Rosengren A, et al. Big Men and Atrial Fibrillation: Effects of Body Size and Weight Gain On Risk of Atrial Fibrillation in Men. Eur Heart J. 2009;30(9):1113-20. PubMed PMID: 19304990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. AU - Rosengren,Annika, AU - Hauptman,Paul J, AU - Lappas,Georg, AU - Olsson,Lars, AU - Wilhelmsen,Lars, AU - Swedberg,Karl, Y1 - 2009/03/20/ PY - 2009/3/24/entrez PY - 2009/3/24/pubmed PY - 2009/7/21/medline SP - 1113 EP - 20 JF - European heart journal JO - Eur Heart J VL - 30 IS - 9 N2 - AIMS: Obesity is a recognized risk factor for atrial fibrillation (AF), partly because of the association between body mass index (BMI) and atrial volume. We aimed to determine whether other factors relating to body size were related to AF. METHODS AND RESULTS: Data were derived from a random population sample of 6903 men (mean age 51.5 years) who underwent a single midlife evaluation as part of the multifactor Swedish Primary Prevention Study. A total of 1253 men (18.2%) had a subsequent hospital discharge diagnosis (principal or secondary) of AF during a maximum follow-up of 34.3 years. Body surface area (BSA) at age 20 (calculated from recalled weight and measured height) was strongly related to subsequent AF (P < 0.0001), as were midlife BMI and weight gain from age 20 to midlife (P < 0.0001). In a Cox regression model which adjusted for midlife BMI, weight gain and other risk factors, hazard ratios (HR) [95% confidence intervals (CI)] for AF for the second, third, and fourth quartile of BSA at age 20, compared with the lowest quartile, were 1.47 (95% CI, 1.22-1.76), 1.66 (95% CI, 1.38-2.00), and 2.22 (95% CI, 1.82-2.70) (P for trend <0.0001). CONCLUSION: Large body size in youth, in an era when obesity was rare, as well as weight gain from age 20 to midlife, were both independently related to the development of AF. Given the current trends not only for obesity but also for height, a substantial increase in the incidence of AF is likely. SN - 1522-9645 UR - https://www.unboundmedicine.com/medline/citation/19304990/Big_men_and_atrial_fibrillation:_effects_of_body_size_and_weight_gain_on_risk_of_atrial_fibrillation_in_men_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehp076 DB - PRIME DP - Unbound Medicine ER -