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Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group.
Digestion. 2009; 79(3):131-6.D

Abstract

BACKGROUND/AIMS

The diagnostic criteria for nonerosive reflux disease (NERD) and functional heartburn (FH) have been changed. We investigated demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors (PPIs) in the gastroesophageal reflux disease (GERD) group.

METHODS

Ninety-five patients with heartburn underwent endoscopy, 24-hour esophageal pH-metry and then a PPI test. NERD was diagnosed when % time with pH <4 was >4%, a symptom index (SI) >or=50% or a positive PPI test in patients without erosive esophagitis. Patients without such findings were classified as FH.

RESULTS

Thirty-six patients had erosive reflux disease (ERD), 36 had NERD, and 23 had FH. The proportion of males was significantly higher in ERD than in FH. Atypical symptoms and IBS were more prevalent in FH than in ERD. Anxiety was more prevalent in FH than in NERD. The prevalence of pathologic acid reflux, a positive SI and a positive PPI test was similar between ERD and NERD patients. In the ERD and NERD groups, depression was independently associated with nonresponsiveness to PPIs.

CONCLUSIONS

FH is a different entity from ERD or NERD, particularly in terms of gender, acid reflux patterns, psychological profiles, and the responsiveness to PPIs.

Authors+Show Affiliations

Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea. kjleemd@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19307735

Citation

Lee, Kwang Jae, et al. "Demographic, Clinical, and Psychological Characteristics of the Heartburn Groups Classified Using the Rome III Criteria and Factors Associated With the Responsiveness to Proton Pump Inhibitors in the Gastroesophageal Reflux Disease Group." Digestion, vol. 79, no. 3, 2009, pp. 131-6.
Lee KJ, Kwon HC, Cheong JY, et al. Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group. Digestion. 2009;79(3):131-6.
Lee, K. J., Kwon, H. C., Cheong, J. Y., & Cho, S. W. (2009). Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group. Digestion, 79(3), 131-6. https://doi.org/10.1159/000209848
Lee KJ, et al. Demographic, Clinical, and Psychological Characteristics of the Heartburn Groups Classified Using the Rome III Criteria and Factors Associated With the Responsiveness to Proton Pump Inhibitors in the Gastroesophageal Reflux Disease Group. Digestion. 2009;79(3):131-6. PubMed PMID: 19307735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group. AU - Lee,Kwang Jae, AU - Kwon,Heok Chun, AU - Cheong,Jae Yeon, AU - Cho,Sung Won, Y1 - 2009/03/23/ PY - 2008/08/14/received PY - 2009/02/03/accepted PY - 2009/3/25/entrez PY - 2009/3/25/pubmed PY - 2009/8/7/medline SP - 131 EP - 6 JF - Digestion JO - Digestion VL - 79 IS - 3 N2 - BACKGROUND/AIMS: The diagnostic criteria for nonerosive reflux disease (NERD) and functional heartburn (FH) have been changed. We investigated demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors (PPIs) in the gastroesophageal reflux disease (GERD) group. METHODS: Ninety-five patients with heartburn underwent endoscopy, 24-hour esophageal pH-metry and then a PPI test. NERD was diagnosed when % time with pH <4 was >4%, a symptom index (SI) >or=50% or a positive PPI test in patients without erosive esophagitis. Patients without such findings were classified as FH. RESULTS: Thirty-six patients had erosive reflux disease (ERD), 36 had NERD, and 23 had FH. The proportion of males was significantly higher in ERD than in FH. Atypical symptoms and IBS were more prevalent in FH than in ERD. Anxiety was more prevalent in FH than in NERD. The prevalence of pathologic acid reflux, a positive SI and a positive PPI test was similar between ERD and NERD patients. In the ERD and NERD groups, depression was independently associated with nonresponsiveness to PPIs. CONCLUSIONS: FH is a different entity from ERD or NERD, particularly in terms of gender, acid reflux patterns, psychological profiles, and the responsiveness to PPIs. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/19307735/Demographic_clinical_and_psychological_characteristics_of_the_heartburn_groups_classified_using_the_Rome_III_criteria_and_factors_associated_with_the_responsiveness_to_proton_pump_inhibitors_in_the_gastroesophageal_reflux_disease_group_ L2 - https://www.karger.com?DOI=10.1159/000209848 DB - PRIME DP - Unbound Medicine ER -