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Stability of drugs of abuse in oral fluid collection devices with purpose of external quality assessment schemes.
Ther Drug Monit. 2009 Apr; 31(2):277-80.TD

Abstract

As the stability of drugs of abuse in oral fluid can affect drug testing results, we evaluated this parameter together with recovery for the principal drugs of abuse in two collection devices typically used to ship oral fluid samples to testing laboratories. Two different samples were prepared using Cozart Drug Detection System and Intercept oral fluid collection devices with 600 ng/mL of 6-monoacetylmorphine (6-MAM) and cocaine and 240 ng/mL of Delta-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-Delta-tetrahydrocannabinol (THCCOOH). Samples were sent at ambient temperature by courier to the participating laboratories (n = 19) the same day of preparation. Samples were analyzed upon reception (about 48-72 hours after shipment). Percent coefficients of variation, calculated using robust mean and robust standard deviation, were around 30% for all analytes, except for THCCOOH in both samples (between 50% and 80%) and THC in 1 sample (50%). Percent coefficients of variation were also high (between 50% and 70%) for morphine and benzoylecgonine, formed after 6-MAM and cocaine spontaneous hydrolysis. On average, 9%-12% 6-MAM was converted to morphine and between 26% and 41% cocaine to benzoylecgonine. Good recoveries were observed for the acid metabolite of THC in both collection devices, whereas THC was always scarcely recovered. Depending on the collection device used, obtained results may confound the interpretation and estimation of blood drug concentration, given an oral fluid drug concentration and subsequent consideration of time elapsing from drug consumption.

Authors+Show Affiliations

Grup de Recerca en Bioanàlisis i Serveis Analítics, Programa de Recerca en Neuropsicofarmacologia, Institut Municipal d'Investigació Mèdica-Hospital del Mar, Universitat Autónoma de Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19307939

Citation

Ventura, Montse, et al. "Stability of Drugs of Abuse in Oral Fluid Collection Devices With Purpose of External Quality Assessment Schemes." Therapeutic Drug Monitoring, vol. 31, no. 2, 2009, pp. 277-80.
Ventura M, Pichini S, Ventura R, et al. Stability of drugs of abuse in oral fluid collection devices with purpose of external quality assessment schemes. Ther Drug Monit. 2009;31(2):277-80.
Ventura, M., Pichini, S., Ventura, R., Leal, S., Zuccaro, P., Pacifici, R., & de la Torre, R. (2009). Stability of drugs of abuse in oral fluid collection devices with purpose of external quality assessment schemes. Therapeutic Drug Monitoring, 31(2), 277-80. https://doi.org/10.1097/FTD.0b013e318198670b
Ventura M, et al. Stability of Drugs of Abuse in Oral Fluid Collection Devices With Purpose of External Quality Assessment Schemes. Ther Drug Monit. 2009;31(2):277-80. PubMed PMID: 19307939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of drugs of abuse in oral fluid collection devices with purpose of external quality assessment schemes. AU - Ventura,Montse, AU - Pichini,Simona, AU - Ventura,Rosa, AU - Leal,Sonia, AU - Zuccaro,Piergiorgio, AU - Pacifici,Roberta, AU - de la Torre,Rafael, PY - 2009/3/25/entrez PY - 2009/3/25/pubmed PY - 2009/4/30/medline SP - 277 EP - 80 JF - Therapeutic drug monitoring JO - Ther Drug Monit VL - 31 IS - 2 N2 - As the stability of drugs of abuse in oral fluid can affect drug testing results, we evaluated this parameter together with recovery for the principal drugs of abuse in two collection devices typically used to ship oral fluid samples to testing laboratories. Two different samples were prepared using Cozart Drug Detection System and Intercept oral fluid collection devices with 600 ng/mL of 6-monoacetylmorphine (6-MAM) and cocaine and 240 ng/mL of Delta-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-Delta-tetrahydrocannabinol (THCCOOH). Samples were sent at ambient temperature by courier to the participating laboratories (n = 19) the same day of preparation. Samples were analyzed upon reception (about 48-72 hours after shipment). Percent coefficients of variation, calculated using robust mean and robust standard deviation, were around 30% for all analytes, except for THCCOOH in both samples (between 50% and 80%) and THC in 1 sample (50%). Percent coefficients of variation were also high (between 50% and 70%) for morphine and benzoylecgonine, formed after 6-MAM and cocaine spontaneous hydrolysis. On average, 9%-12% 6-MAM was converted to morphine and between 26% and 41% cocaine to benzoylecgonine. Good recoveries were observed for the acid metabolite of THC in both collection devices, whereas THC was always scarcely recovered. Depending on the collection device used, obtained results may confound the interpretation and estimation of blood drug concentration, given an oral fluid drug concentration and subsequent consideration of time elapsing from drug consumption. SN - 1536-3694 UR - https://www.unboundmedicine.com/medline/citation/19307939/Stability_of_drugs_of_abuse_in_oral_fluid_collection_devices_with_purpose_of_external_quality_assessment_schemes_ L2 - http://dx.doi.org/10.1097/FTD.0b013e318198670b DB - PRIME DP - Unbound Medicine ER -