Tags

Type your tag names separated by a space and hit enter

5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning.
Hippocampus. 2009 Dec; 19(12):1187-98.H

Abstract

Cholinergic and GABAergic neurons in the medial septum/vertical limb of the diagonal band of Broca (MS/vDB) projecting to the hippocampus, constitute the septohippocampal projection, which is important for hippocampal-dependent learning and memory. There is also evidence for an extrinsic as well as an intrinsic glutamatergic network within the MS/vDB. GABAergic and cholinergic septohippocampal neurons express the serotonergic 5-HT(1A) receptor and most likely also glutamatergic NMDA receptors. The aim of the present study was to examine whether septal 5-HT(1A) receptors are important for hippocampal-dependent long-term memory and whether these receptors interact with glutamatergic NMDA receptor transmission in a manner important for hippocampal-dependent spatial memory. Intraseptal infusion of the 5-HT(1A) receptor agonist (R)-8-OH-DPAT (1 or 4 microg/rat) did not affect spatial learning in the water maze task but impaired emotional memory in the passive avoidance task at the higher dose tested (4 microg/rat). While intraseptal administration of (R)-8-OH-DPAT (4 microg) combined with a subthreshold dose of the NMDA receptor antagonist D-AP5 (1 microg) only marginally affected spatial acquisition, it produced a profound impairment in spatial memory. In conclusion, septal 5-HT(1A) receptors appears to play a more prominent role in emotional than in spatial memory. Importantly, septal 5-HT(1A) and NMDA receptors appear to interact in a manner, which is particularly critical for the expression or retrieval of hippocampal-dependent long-term spatial memory. It is proposed that NMDA receptor hypofunction in the septal area may unmask a negative effect of 5-HT(1A) receptor activation on memory, which may be clinically relevant.

Authors+Show Affiliations

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. elin.elvander.tottie@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19309036

Citation

Elvander-Tottie, Elin, et al. "5-HT(1A) and NMDA Receptors Interact in the Rat Medial Septum and Modulate Hippocampal-dependent Spatial Learning." Hippocampus, vol. 19, no. 12, 2009, pp. 1187-98.
Elvander-Tottie E, Eriksson TM, Sandin J, et al. 5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning. Hippocampus. 2009;19(12):1187-98.
Elvander-Tottie, E., Eriksson, T. M., Sandin, J., & Ogren, S. O. (2009). 5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning. Hippocampus, 19(12), 1187-98. https://doi.org/10.1002/hipo.20596
Elvander-Tottie E, et al. 5-HT(1A) and NMDA Receptors Interact in the Rat Medial Septum and Modulate Hippocampal-dependent Spatial Learning. Hippocampus. 2009;19(12):1187-98. PubMed PMID: 19309036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-HT(1A) and NMDA receptors interact in the rat medial septum and modulate hippocampal-dependent spatial learning. AU - Elvander-Tottie,Elin, AU - Eriksson,Therese M, AU - Sandin,Johan, AU - Ogren,Sven Ove, PY - 2009/3/25/entrez PY - 2009/3/25/pubmed PY - 2010/1/29/medline SP - 1187 EP - 98 JF - Hippocampus JO - Hippocampus VL - 19 IS - 12 N2 - Cholinergic and GABAergic neurons in the medial septum/vertical limb of the diagonal band of Broca (MS/vDB) projecting to the hippocampus, constitute the septohippocampal projection, which is important for hippocampal-dependent learning and memory. There is also evidence for an extrinsic as well as an intrinsic glutamatergic network within the MS/vDB. GABAergic and cholinergic septohippocampal neurons express the serotonergic 5-HT(1A) receptor and most likely also glutamatergic NMDA receptors. The aim of the present study was to examine whether septal 5-HT(1A) receptors are important for hippocampal-dependent long-term memory and whether these receptors interact with glutamatergic NMDA receptor transmission in a manner important for hippocampal-dependent spatial memory. Intraseptal infusion of the 5-HT(1A) receptor agonist (R)-8-OH-DPAT (1 or 4 microg/rat) did not affect spatial learning in the water maze task but impaired emotional memory in the passive avoidance task at the higher dose tested (4 microg/rat). While intraseptal administration of (R)-8-OH-DPAT (4 microg) combined with a subthreshold dose of the NMDA receptor antagonist D-AP5 (1 microg) only marginally affected spatial acquisition, it produced a profound impairment in spatial memory. In conclusion, septal 5-HT(1A) receptors appears to play a more prominent role in emotional than in spatial memory. Importantly, septal 5-HT(1A) and NMDA receptors appear to interact in a manner, which is particularly critical for the expression or retrieval of hippocampal-dependent long-term spatial memory. It is proposed that NMDA receptor hypofunction in the septal area may unmask a negative effect of 5-HT(1A) receptor activation on memory, which may be clinically relevant. SN - 1098-1063 UR - https://www.unboundmedicine.com/medline/citation/19309036/5_HT_1A__and_NMDA_receptors_interact_in_the_rat_medial_septum_and_modulate_hippocampal_dependent_spatial_learning_ L2 - https://doi.org/10.1002/hipo.20596 DB - PRIME DP - Unbound Medicine ER -