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Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic?
Comp Immunol Microbiol Infect Dis. 2009 Jul; 32(4):287-300.CI

Abstract

Since 1997, when human infections with a highly pathogenic (HP) avian influenza A virus (AIV) subtype H5N1 - previously infecting only birds - were identified in a Hong Kong outbreak, global attention has focused on the potential for this virus to cause the next pandemic. From December 2003, an unprecedented H5N1 epizootic in poultry and migrating wild birds has spread across Asia and into Europe, the Middle East, and Africa. Humans in close contact with sick poultry and on rare occasion with other infected humans, have become infected. As of early March 2007, 12 countries have reported 167 deaths among 277 laboratory-confirmed human infections to WHO. WHO has declared the world to be in Phase 3 of a Pandemic Alert Period. This paper reviews the evolution of HP AIV H5N1, molecular changes that enable AIVs to infect and replicate in human cells and spread efficiently from person-to-person, and strategies to prevent the emergence of a pandemic virus.

Authors+Show Affiliations

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S. Second Street, Suite 300, Minneapolis, MN 55454, USA. pappa046@umn.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19318178

Citation

Pappaioanou, Marguerite. "Highly Pathogenic H5N1 Avian Influenza Virus: Cause of the Next Pandemic?" Comparative Immunology, Microbiology and Infectious Diseases, vol. 32, no. 4, 2009, pp. 287-300.
Pappaioanou M. Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic? Comp Immunol Microbiol Infect Dis. 2009;32(4):287-300.
Pappaioanou, M. (2009). Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic? Comparative Immunology, Microbiology and Infectious Diseases, 32(4), 287-300. https://doi.org/10.1016/j.cimid.2008.01.003
Pappaioanou M. Highly Pathogenic H5N1 Avian Influenza Virus: Cause of the Next Pandemic. Comp Immunol Microbiol Infect Dis. 2009;32(4):287-300. PubMed PMID: 19318178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic? A1 - Pappaioanou,Marguerite, PY - 2008/01/11/accepted PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/4/29/medline SP - 287 EP - 300 JF - Comparative immunology, microbiology and infectious diseases JO - Comp. Immunol. Microbiol. Infect. Dis. VL - 32 IS - 4 N2 - Since 1997, when human infections with a highly pathogenic (HP) avian influenza A virus (AIV) subtype H5N1 - previously infecting only birds - were identified in a Hong Kong outbreak, global attention has focused on the potential for this virus to cause the next pandemic. From December 2003, an unprecedented H5N1 epizootic in poultry and migrating wild birds has spread across Asia and into Europe, the Middle East, and Africa. Humans in close contact with sick poultry and on rare occasion with other infected humans, have become infected. As of early March 2007, 12 countries have reported 167 deaths among 277 laboratory-confirmed human infections to WHO. WHO has declared the world to be in Phase 3 of a Pandemic Alert Period. This paper reviews the evolution of HP AIV H5N1, molecular changes that enable AIVs to infect and replicate in human cells and spread efficiently from person-to-person, and strategies to prevent the emergence of a pandemic virus. SN - 1878-1667 UR - https://www.unboundmedicine.com/medline/citation/19318178/Highly_pathogenic_H5N1_avian_influenza_virus:_cause_of_the_next_pandemic L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-9571(08)00006-4 DB - PRIME DP - Unbound Medicine ER -