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Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.
Acta Anaesthesiol Taiwan. 2009 Mar; 47(1):3-9.AA

Abstract

BACKGROUND

A combination of antiemetic drugs could be an effective method to prevent severe postoperative nausea and vomiting (PONV). Therefore, we examined the prophylactic effect of haloperidol plus ondansetron on PONV.

METHODS

We enrolled 210 patients (n = 70 in each of 3 groups) undergoing elective laparoscopic cholecystectomy for this randomized double-blind study. Patients were randomized to intravenous saline 2 mL and intramuscular haloperidol 2 mg (Group H), intravenous ondansetron 4 mg and intramuscular saline 2 mL (Group O), or intravenous ondansetron 4 mg and intramuscular haloperidol 2 mg (Group H+O), administered after induction of general anesthesia and 30 minutes before the conclusion of surgery. We compared the complete response rates, incidence of PONV, nausea scores, the need for rescue medication, patient satisfaction scores, and adverse events during the 24-hour study.

RESULTS

The H+O group had the highest complete response rate to treatment (79%) compared with group H (61%) and group O (62%) (p < 0.05 for both). Patient satisfaction scores were significantly higher in the H+O group (8.3 +/- 1.8) than in the H (7.0 +/- 2.4) and O (7.2 +/- 2.5) groups (p < 0.05 for both). In addition, nausea scores were significantly lower in the H+O group (1.2 +/- 2.6) than in the H (2.5 +/- 3.3) and O (2.2 +/- 3.1) groups (p < 0.05 for both).

CONCLUSION

We conclude that the combination of prophylactic haloperidol (2 mg) plus ondansetron (4 mg) provides a higher complete response rate and greater patient satisfaction after laparoscopic cholecystectomy than either drug used alone.

Authors+Show Affiliations

Department of Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan, R.O.C.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19318293

Citation

Feng, Ping-Hsun, et al. "Haloperidol Plus Ondansetron Prevents Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy." Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists, vol. 47, no. 1, 2009, pp. 3-9.
Feng PH, Chu KS, Lu IC, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan. 2009;47(1):3-9.
Feng, P. H., Chu, K. S., Lu, I. C., Shieh, J. P., Tzeng, J. I., Ho, S. T., Wang, J. J., & Chu, C. C. (2009). Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists, 47(1), 3-9. https://doi.org/10.1016/S1875-4597(09)60013-8
Feng PH, et al. Haloperidol Plus Ondansetron Prevents Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy. Acta Anaesthesiol Taiwan. 2009;47(1):3-9. PubMed PMID: 19318293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. AU - Feng,Ping-Hsun, AU - Chu,Koung-Shing, AU - Lu,I-Chen, AU - Shieh,Ja-Ping, AU - Tzeng,Jann-Inn, AU - Ho,Shung-Tai, AU - Wang,Jhi-Joung, AU - Chu,Chin-Chen, PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/7/25/medline SP - 3 EP - 9 JF - Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists JO - Acta Anaesthesiol Taiwan VL - 47 IS - 1 N2 - BACKGROUND: A combination of antiemetic drugs could be an effective method to prevent severe postoperative nausea and vomiting (PONV). Therefore, we examined the prophylactic effect of haloperidol plus ondansetron on PONV. METHODS: We enrolled 210 patients (n = 70 in each of 3 groups) undergoing elective laparoscopic cholecystectomy for this randomized double-blind study. Patients were randomized to intravenous saline 2 mL and intramuscular haloperidol 2 mg (Group H), intravenous ondansetron 4 mg and intramuscular saline 2 mL (Group O), or intravenous ondansetron 4 mg and intramuscular haloperidol 2 mg (Group H+O), administered after induction of general anesthesia and 30 minutes before the conclusion of surgery. We compared the complete response rates, incidence of PONV, nausea scores, the need for rescue medication, patient satisfaction scores, and adverse events during the 24-hour study. RESULTS: The H+O group had the highest complete response rate to treatment (79%) compared with group H (61%) and group O (62%) (p < 0.05 for both). Patient satisfaction scores were significantly higher in the H+O group (8.3 +/- 1.8) than in the H (7.0 +/- 2.4) and O (7.2 +/- 2.5) groups (p < 0.05 for both). In addition, nausea scores were significantly lower in the H+O group (1.2 +/- 2.6) than in the H (2.5 +/- 3.3) and O (2.2 +/- 3.1) groups (p < 0.05 for both). CONCLUSION: We conclude that the combination of prophylactic haloperidol (2 mg) plus ondansetron (4 mg) provides a higher complete response rate and greater patient satisfaction after laparoscopic cholecystectomy than either drug used alone. SN - 1875-4597 UR - https://www.unboundmedicine.com/medline/citation/19318293/Haloperidol_plus_ondansetron_prevents_postoperative_nausea_and_vomiting_in_patients_undergoing_laparoscopic_cholecystectomy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1875-4597(09)60013-8 DB - PRIME DP - Unbound Medicine ER -