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Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine.
Eur Cytokine Netw 2009; 20(1):27-32EC

Abstract

BACKGROUND

Hashimoto's thyroiditis is a chronic, organ-specific autoimmune disease. It is the most common cause of primary hypothyroidism during the adolescent period, via autoimmune thyroid tissue destruction, affecting 2% of the population. The pathogenesis of Hashimoto's thyroiditis involves a complex interaction between predisposing genetic and environmental factors.

OBJECTIVE

In this study, we wanted to investigate the role of cytokines such as IL-2, IL-4, IL-12 and IFN-gamma in the pathogenesis of the disease, and the changes to cytokine levels brought about by treatment with L-thyroxine.

METHODS

Sixty five female patients, aged 18-73 years with Hashimoto's thyroiditis, referred to the Celal Bayar University Medical Faculty Endocrinology out-patients clinic, were included in this study. After a 10-12 week period of L-thyroxine treatment, all patients were restored to the euthyroid state. At the beginning and end of the treatment period, serum-free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), autoantibodies against thyroid peroxidase (anti-TPO), autoantibodies against thyroglobulin (anti-Tg) levels were measured using a chemiluminecent, immunometric method, and cytokine levels were measured using ELISA.

RESULTS

There was a statistically significant decrease in the serum levels of TSH (p < 0.0001) and a concomitant increase in FT4 serum levels (p < 0.0001). Also, during the post-treatment period, serum levels of anti-Tg (p < 0.01) and anti-TPO (p < 0.001) were significantly lower than during the pre-treatment period. A statistically significant decrease was shown for interleukin (IL)-12 serum levels during the post-treatment period (p < 0.001). However, the decrease in interferon (IFN)-gamma serum levels was not statistically significant (p = 0.276). On the other hand, no change was demonstrated in serum IL-2 and IL-4 levels (p = 0.953 and p = 0.313, respectively) after treatment with L-thyroxine.

CONCLUSION

Considering that our study involved a 10-12 week period of treatment, the statistically significant decrease in serum IL-12 levels, and the statistically non-significant decrease in IFN-gamma levels, might indicate that a T helper type 1 inflammatory process had been halted or slowed down.

Authors+Show Affiliations

Celal Bayar University, Medical Faculty, Department of Internal Medicine, Division of Endocrinology, Manisa, Turkiye.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19318318

Citation

Guclu, Feyzullah, et al. "Down-regulation of the Auto-aggressive Processes in Patients With Hypothyroid Hashimoto's Thyroiditis Following Substitutive Treatment With L-thyroxine." European Cytokine Network, vol. 20, no. 1, 2009, pp. 27-32.
Guclu F, Ozmen B, Kirmaz C, et al. Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine. Eur Cytokine Netw. 2009;20(1):27-32.
Guclu, F., Ozmen, B., Kirmaz, C., Kafesciler, S. O., Degirmenci, P. B., Taneli, F., & Hekimsoy, Z. (2009). Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine. European Cytokine Network, 20(1), pp. 27-32. doi:10.1684/ecn.2009.0147.
Guclu F, et al. Down-regulation of the Auto-aggressive Processes in Patients With Hypothyroid Hashimoto's Thyroiditis Following Substitutive Treatment With L-thyroxine. Eur Cytokine Netw. 2009;20(1):27-32. PubMed PMID: 19318318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down-regulation of the auto-aggressive processes in patients with hypothyroid Hashimoto's thyroiditis following substitutive treatment with L-thyroxine. AU - Guclu,Feyzullah, AU - Ozmen,Bilgin, AU - Kirmaz,Cengiz, AU - Kafesciler,Sabriye Ozkaya, AU - Degirmenci,Papatya Bayrak, AU - Taneli,Fatma, AU - Hekimsoy,Zeliha, PY - 2009/3/26/entrez PY - 2008/1/1/pubmed PY - 2011/1/5/medline SP - 27 EP - 32 JF - European cytokine network JO - Eur. Cytokine Netw. VL - 20 IS - 1 N2 - BACKGROUND: Hashimoto's thyroiditis is a chronic, organ-specific autoimmune disease. It is the most common cause of primary hypothyroidism during the adolescent period, via autoimmune thyroid tissue destruction, affecting 2% of the population. The pathogenesis of Hashimoto's thyroiditis involves a complex interaction between predisposing genetic and environmental factors. OBJECTIVE: In this study, we wanted to investigate the role of cytokines such as IL-2, IL-4, IL-12 and IFN-gamma in the pathogenesis of the disease, and the changes to cytokine levels brought about by treatment with L-thyroxine. METHODS: Sixty five female patients, aged 18-73 years with Hashimoto's thyroiditis, referred to the Celal Bayar University Medical Faculty Endocrinology out-patients clinic, were included in this study. After a 10-12 week period of L-thyroxine treatment, all patients were restored to the euthyroid state. At the beginning and end of the treatment period, serum-free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), autoantibodies against thyroid peroxidase (anti-TPO), autoantibodies against thyroglobulin (anti-Tg) levels were measured using a chemiluminecent, immunometric method, and cytokine levels were measured using ELISA. RESULTS: There was a statistically significant decrease in the serum levels of TSH (p < 0.0001) and a concomitant increase in FT4 serum levels (p < 0.0001). Also, during the post-treatment period, serum levels of anti-Tg (p < 0.01) and anti-TPO (p < 0.001) were significantly lower than during the pre-treatment period. A statistically significant decrease was shown for interleukin (IL)-12 serum levels during the post-treatment period (p < 0.001). However, the decrease in interferon (IFN)-gamma serum levels was not statistically significant (p = 0.276). On the other hand, no change was demonstrated in serum IL-2 and IL-4 levels (p = 0.953 and p = 0.313, respectively) after treatment with L-thyroxine. CONCLUSION: Considering that our study involved a 10-12 week period of treatment, the statistically significant decrease in serum IL-12 levels, and the statistically non-significant decrease in IFN-gamma levels, might indicate that a T helper type 1 inflammatory process had been halted or slowed down. SN - 1952-4005 UR - https://www.unboundmedicine.com/medline/citation/19318318/Down_regulation_of_the_auto_aggressive_processes_in_patients_with_hypothyroid_Hashimoto's_thyroiditis_following_substitutive_treatment_with_L_thyroxine_ L2 - http://www.jle.com/medline.md?issn=1148-5493&amp;vol=20&amp;iss=1&amp;page=27 DB - PRIME DP - Unbound Medicine ER -