Tags

Type your tag names separated by a space and hit enter

Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis.
Mult Scler. 2009 May; 15(5):547-54.MS

Abstract

BACKGROUND

Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS).

OBJECTIVE

To elucidate the actual implication of MMP-2 and TIMP-2 in MS.

METHODS

Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 were measured by activity assay system and ELISA, respectively, in 67 patients with relapsing-remitting MS (RRMS), categorized according clinical and magnetic resonance imaging (MRI), and in 129 controls.

RESULTS

Cerebrospinal fluid and serum active MMP-2/TIMP-2 ratio mean values and an intrathecal active MMP-2 production were more increased in RRMS than in non-inflammatory conditions (P < 0.001, P < 0.05, and P < 0.0001, respectively) and in MRI inactive than in MRI active RRMS (P < 0.02, P < 0.01 and P < 0.001, respectively). An intrathecal synthesis of active MMP-2 was more frequent in RRMS than in inflammatory disorders (P < 0.01). Serum active MMP-2/TIMP-2 ratio and MS disease duration were positively correlated (P < 0.02).

CONCLUSION

These findings suggest a potential role for MMP-2 activity in the termination of MS neuroinflammation related to remission of the disease and seem to indicate that serum MMP-2/TIMP-2 ratio may represent a useful biomarker for monitoring MS recovery phase.

Authors+Show Affiliations

Neuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Corso della Giovecca 203, Ferrara I-44100, Italy. henryfai@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19318509

Citation

Fainardi, E, et al. "Potential Relevance of Cerebrospinal Fluid and Serum Levels and Intrathecal Synthesis of Active Matrix Metalloproteinase-2 (MMP-2) as Markers of Disease Remission in Patients With Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 15, no. 5, 2009, pp. 547-54.
Fainardi E, Castellazzi M, Tamborino C, et al. Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis. Mult Scler. 2009;15(5):547-54.
Fainardi, E., Castellazzi, M., Tamborino, C., Trentini, A., Manfrinato, M. C., Baldi, E., Tola, M. R., Dallocchio, F., Granieri, E., & Bellini, T. (2009). Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 15(5), 547-54. https://doi.org/10.1177/1352458509102372
Fainardi E, et al. Potential Relevance of Cerebrospinal Fluid and Serum Levels and Intrathecal Synthesis of Active Matrix Metalloproteinase-2 (MMP-2) as Markers of Disease Remission in Patients With Multiple Sclerosis. Mult Scler. 2009;15(5):547-54. PubMed PMID: 19318509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis. AU - Fainardi,E, AU - Castellazzi,M, AU - Tamborino,C, AU - Trentini,A, AU - Manfrinato,M C, AU - Baldi,E, AU - Tola,M R, AU - Dallocchio,F, AU - Granieri,E, AU - Bellini,T, Y1 - 2009/03/24/ PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/7/25/medline SP - 547 EP - 54 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult Scler VL - 15 IS - 5 N2 - BACKGROUND: Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS). OBJECTIVE: To elucidate the actual implication of MMP-2 and TIMP-2 in MS. METHODS: Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 were measured by activity assay system and ELISA, respectively, in 67 patients with relapsing-remitting MS (RRMS), categorized according clinical and magnetic resonance imaging (MRI), and in 129 controls. RESULTS: Cerebrospinal fluid and serum active MMP-2/TIMP-2 ratio mean values and an intrathecal active MMP-2 production were more increased in RRMS than in non-inflammatory conditions (P < 0.001, P < 0.05, and P < 0.0001, respectively) and in MRI inactive than in MRI active RRMS (P < 0.02, P < 0.01 and P < 0.001, respectively). An intrathecal synthesis of active MMP-2 was more frequent in RRMS than in inflammatory disorders (P < 0.01). Serum active MMP-2/TIMP-2 ratio and MS disease duration were positively correlated (P < 0.02). CONCLUSION: These findings suggest a potential role for MMP-2 activity in the termination of MS neuroinflammation related to remission of the disease and seem to indicate that serum MMP-2/TIMP-2 ratio may represent a useful biomarker for monitoring MS recovery phase. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/19318509/Potential_relevance_of_cerebrospinal_fluid_and_serum_levels_and_intrathecal_synthesis_of_active_matrix_metalloproteinase_2__MMP_2__as_markers_of_disease_remission_in_patients_with_multiple_sclerosis_ L2 - https://journals.sagepub.com/doi/10.1177/1352458509102372?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -