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Alcohol consumption and risk of pancreatic cancer in the Netherlands cohort study.
Am J Epidemiol 2009; 169(10):1233-42AJ

Abstract

To examine prospectively the relation between alcohol consumption and pancreatic cancer risk, the authors analyzed data from the Netherlands Cohort Study. Participants were 120,852 persons who completed a baseline questionnaire in 1986. After 13.3 years of follow-up, 350 cases of pancreatic cancer (67% microscopically confirmed) were available for analysis. Compared with abstention, the highest category of alcohol consumption (> or =30 g/day of ethanol) was positively associated with pancreatic cancer risk (for all cases, rate ratio = 1.57, 95% confidence interval: 1.03, 2.39; P(trend) = 0.12; for microscopically confirmed cases, rate ratio = 1.54, 95% confidence interval: 0.94, 2.54; P(trend) = 0.22). In a subgroup of stable alcohol users (no change during the 5 years before baseline), a similarly increased risk of pancreatic cancer was found. This increased risk was limited to the first 7 years of follow-up. No associations were observed between consumption of specific alcoholic beverages and risk of pancreatic cancer. The associations were not modified by folate intake or smoking. Overall, these findings suggest an increased pancreatic cancer risk for persons with a high ethanol intake (> or =30 g/day). However, this increased risk was observed only during the first 7 years of follow-up.

Authors+Show Affiliations

Department of Epidemiology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. mirjam.heinen@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19318612

Citation

Heinen, Mirjam M., et al. "Alcohol Consumption and Risk of Pancreatic Cancer in the Netherlands Cohort Study." American Journal of Epidemiology, vol. 169, no. 10, 2009, pp. 1233-42.
Heinen MM, Verhage BA, Ambergen TA, et al. Alcohol consumption and risk of pancreatic cancer in the Netherlands cohort study. Am J Epidemiol. 2009;169(10):1233-42.
Heinen, M. M., Verhage, B. A., Ambergen, T. A., Goldbohm, R. A., & van den Brandt, P. A. (2009). Alcohol consumption and risk of pancreatic cancer in the Netherlands cohort study. American Journal of Epidemiology, 169(10), pp. 1233-42. doi:10.1093/aje/kwp028.
Heinen MM, et al. Alcohol Consumption and Risk of Pancreatic Cancer in the Netherlands Cohort Study. Am J Epidemiol. 2009 May 15;169(10):1233-42. PubMed PMID: 19318612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of pancreatic cancer in the Netherlands cohort study. AU - Heinen,Mirjam M, AU - Verhage,Bas A J, AU - Ambergen,Ton A W, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, Y1 - 2009/03/24/ PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/6/9/medline SP - 1233 EP - 42 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 169 IS - 10 N2 - To examine prospectively the relation between alcohol consumption and pancreatic cancer risk, the authors analyzed data from the Netherlands Cohort Study. Participants were 120,852 persons who completed a baseline questionnaire in 1986. After 13.3 years of follow-up, 350 cases of pancreatic cancer (67% microscopically confirmed) were available for analysis. Compared with abstention, the highest category of alcohol consumption (> or =30 g/day of ethanol) was positively associated with pancreatic cancer risk (for all cases, rate ratio = 1.57, 95% confidence interval: 1.03, 2.39; P(trend) = 0.12; for microscopically confirmed cases, rate ratio = 1.54, 95% confidence interval: 0.94, 2.54; P(trend) = 0.22). In a subgroup of stable alcohol users (no change during the 5 years before baseline), a similarly increased risk of pancreatic cancer was found. This increased risk was limited to the first 7 years of follow-up. No associations were observed between consumption of specific alcoholic beverages and risk of pancreatic cancer. The associations were not modified by folate intake or smoking. Overall, these findings suggest an increased pancreatic cancer risk for persons with a high ethanol intake (> or =30 g/day). However, this increased risk was observed only during the first 7 years of follow-up. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19318612/Alcohol_consumption_and_risk_of_pancreatic_cancer_in_the_Netherlands_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp028 DB - PRIME DP - Unbound Medicine ER -