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Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas.
Reprod Sci. 2009 Jun; 16(6):591-5.RS

Abstract

The association of Ewing's sarcoma/peripheral neuroectodermal tumor and endometrioid type endometrial carcinoma has been reported relatively recently. We have recently identified Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in uterine serous carcinomas and undertook this study to evaluate the frequency of both serous and endometrioid carcinomas expressing Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Seventy cases of uterine serous carcinoma were retrieved from the archival files and stained with antibodies to CD99. Positive and negative control slides were run with each staining batch. Perinuclear dot-like and/or membranous staining was regarded as positive. The frequency of Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in 56 FIGO grade 3 endometrioid carcinomas was also determined and 7% uterine serous and 12.5% of FIGO grade 3 endometrioid endometrial carcinomas showed Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Given the worse prognosis associated with Ewing's sarcoma/peripheral neuroectodermal tumor differentiation, even in neoplasms already at high risk for recurrence and metastasis, a high index of suspicion for Ewing's sarcoma/peripheral neuroectodermal tumor should be maintained in high-grade uterine serous carcinomas.

Authors+Show Affiliations

Department of Pathology & Laboratory Medicine, Women & Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA. mquddus@wihri.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19318687

Citation

Quddus, M Ruhul, et al. "Ewing's Sarcoma/peripheral Primitive Neuroectodermal Tumor (ES/PNET) Differentiation in Endometrial Serous Carcinomas." Reproductive Sciences (Thousand Oaks, Calif.), vol. 16, no. 6, 2009, pp. 591-5.
Quddus MR, Rashid L, Sung CJ, et al. Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas. Reprod Sci. 2009;16(6):591-5.
Quddus, M. R., Rashid, L., Sung, C. J., Steinhoff, M. M., Cunxian Zhang, ., & Lawrence, W. D. (2009). Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas. Reproductive Sciences (Thousand Oaks, Calif.), 16(6), 591-5. https://doi.org/10.1177/1933719109332824
Quddus MR, et al. Ewing's Sarcoma/peripheral Primitive Neuroectodermal Tumor (ES/PNET) Differentiation in Endometrial Serous Carcinomas. Reprod Sci. 2009;16(6):591-5. PubMed PMID: 19318687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ewing's sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) differentiation in endometrial serous carcinomas. AU - Quddus,M Ruhul, AU - Rashid,Lanita, AU - Sung,C James, AU - Steinhoff,Margaret M, AU - Cunxian Zhang,, AU - Lawrence,W Dwayne, Y1 - 2009/03/24/ PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2011/3/30/medline SP - 591 EP - 5 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 16 IS - 6 N2 - The association of Ewing's sarcoma/peripheral neuroectodermal tumor and endometrioid type endometrial carcinoma has been reported relatively recently. We have recently identified Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in uterine serous carcinomas and undertook this study to evaluate the frequency of both serous and endometrioid carcinomas expressing Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Seventy cases of uterine serous carcinoma were retrieved from the archival files and stained with antibodies to CD99. Positive and negative control slides were run with each staining batch. Perinuclear dot-like and/or membranous staining was regarded as positive. The frequency of Ewing's sarcoma/peripheral neuroectodermal tumor differentiation in 56 FIGO grade 3 endometrioid carcinomas was also determined and 7% uterine serous and 12.5% of FIGO grade 3 endometrioid endometrial carcinomas showed Ewing's sarcoma/peripheral neuroectodermal tumor differentiation. Given the worse prognosis associated with Ewing's sarcoma/peripheral neuroectodermal tumor differentiation, even in neoplasms already at high risk for recurrence and metastasis, a high index of suspicion for Ewing's sarcoma/peripheral neuroectodermal tumor should be maintained in high-grade uterine serous carcinomas. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/19318687/Ewing's_sarcoma/peripheral_primitive_neuroectodermal_tumor__ES/PNET__differentiation_in_endometrial_serous_carcinomas_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719109332824?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -