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Probiotics and prevention of allergic disease.
Curr Opin Clin Nutr Metab Care. 2009 May; 12(3):298-303.CO

Abstract

PURPOSE OF REVIEW

Over the past few decades, public reports have shown increasing enthusiasm for the potential health effects of probiotics. Therefore, the purpose of this review is to focus on studies, which have addressed the use of probiotics for primary prevention of atopic diseases.

RECENT FINDINGS

The Finnish study of Kalliomaki was the first report to describe that the frequency of atopic dermatitis in neonates treated with Lactobacillus rhamnosus GG (LGG) was half that of the placebo. Recently, these results have been questioned by two trials, which reported no difference in the development of atopic dermatitis in neonates supplemented with LGG and L. acidophilus, respectively. In contrast, an unexpected increase in respiratory side-effects was observed in some studies in children who received the probiotics. Up to now no data have been released which report a positive effect of probiotics for the prevention of allergic rhinitis or asthma. Moreover, an allergen-preventive effect of probiotics for the development of atopic dermatitis could not be consistently established.

SUMMARY

In conclusion, probiotics cannot be generally recommended for primary prevention of atopic disease. Further studies should clarify if any susceptible subgroups exist and how these subgroups benefit from supplementation with certain probiotic strains. Moreover, the selection of the most beneficial probiotic strain or the composition of different probiotics and/or prebiotics, the dose and the timing of supplementation still need to be determined.

Authors+Show Affiliations

University Hospital, Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, Freiburg, Germany. matthias.kopp@uniklinik-freiburg.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19318939

Citation

Kopp, Matthias V., and Peter Salfeld. "Probiotics and Prevention of Allergic Disease." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 3, 2009, pp. 298-303.
Kopp MV, Salfeld P. Probiotics and prevention of allergic disease. Curr Opin Clin Nutr Metab Care. 2009;12(3):298-303.
Kopp, M. V., & Salfeld, P. (2009). Probiotics and prevention of allergic disease. Current Opinion in Clinical Nutrition and Metabolic Care, 12(3), 298-303. https://doi.org/10.1097/MCO.0b013e32832989a3
Kopp MV, Salfeld P. Probiotics and Prevention of Allergic Disease. Curr Opin Clin Nutr Metab Care. 2009;12(3):298-303. PubMed PMID: 19318939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics and prevention of allergic disease. AU - Kopp,Matthias V, AU - Salfeld,Peter, PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/5/15/medline SP - 298 EP - 303 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 12 IS - 3 N2 - PURPOSE OF REVIEW: Over the past few decades, public reports have shown increasing enthusiasm for the potential health effects of probiotics. Therefore, the purpose of this review is to focus on studies, which have addressed the use of probiotics for primary prevention of atopic diseases. RECENT FINDINGS: The Finnish study of Kalliomaki was the first report to describe that the frequency of atopic dermatitis in neonates treated with Lactobacillus rhamnosus GG (LGG) was half that of the placebo. Recently, these results have been questioned by two trials, which reported no difference in the development of atopic dermatitis in neonates supplemented with LGG and L. acidophilus, respectively. In contrast, an unexpected increase in respiratory side-effects was observed in some studies in children who received the probiotics. Up to now no data have been released which report a positive effect of probiotics for the prevention of allergic rhinitis or asthma. Moreover, an allergen-preventive effect of probiotics for the development of atopic dermatitis could not be consistently established. SUMMARY: In conclusion, probiotics cannot be generally recommended for primary prevention of atopic disease. Further studies should clarify if any susceptible subgroups exist and how these subgroups benefit from supplementation with certain probiotic strains. Moreover, the selection of the most beneficial probiotic strain or the composition of different probiotics and/or prebiotics, the dose and the timing of supplementation still need to be determined. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/19318939/Probiotics_and_prevention_of_allergic_disease_ L2 - http://dx.doi.org/10.1097/MCO.0b013e32832989a3 DB - PRIME DP - Unbound Medicine ER -