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Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers.

Abstract

BACKGROUND/OBJECTIVES

There is convincing evidence that a high dietary fiber intake may lower the risk of coronary heart disease. However, the role of fiber in the prevention of stroke is unclear. We examined the associations of dietary fiber and fiber-rich food intake with risk of stroke within the Alpha-tocopherol, Beta-carotene Cancer Prevention Study.

SUBJECTS/METHODS

Between 1985 and 1988, 26,556 Finnish male smokers aged 50-69 years, who had no history of stroke, completed a dietary questionnaire. During a mean follow-up of 13.6 years, 2702 cerebral infarctions, 383 intracerebral hemorrhages and 196 subarachnoid hemorrhages were ascertained.

RESULTS

After adjustment for cardiovascular risk factors and folate and magnesium intakes, there was no significant association between intake of total fiber, water-soluble fiber, water-insoluble fiber, or fiber derived from fruit or cereal sources and risk of any stroke subtype. Vegetable fiber intake, as well as the consumption of fruit, vegetables and cereals, was inversely associated with the risk of cerebral infarction; the multivariate relative risks for the highest quintile of intake as compared with the lowest were 0.86 (95% confidence interval (CI): 0.76-0.99) for vegetable fiber, 0.82 (95% CI: 0.73-0.93) for fruit, 0.75 (95% CI: 0.66-0.85) for vegetables and 0.87 (95% CI: 0.74-1.03) for cereals. Vegetable consumption was inversely associated with risk of subarachnoid hemorrhage (relative risk for highest versus lowest quintile: 0.62; 95% CI: 0.40-0.98), and cereal consumption was inversely associated with risk of intracerebral hemorrhage (relative risk: 0.64; 95% CI: 0.41-1.01).

CONCLUSIONS

These findings suggest a beneficial effect of the consumption of fruits, vegetables and cereals on stroke risk.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se

    , , , ,

    Source

    MeSH

    Cerebral Hemorrhage
    Cerebral Infarction
    Diet
    Dietary Fiber
    Edible Grain
    Finland
    Fruit
    Humans
    Male
    Middle Aged
    Risk Factors
    Smoking
    Stroke
    Subarachnoid Hemorrhage
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19319150

    Citation

    Larsson, S C., et al. "Dietary Fiber and Fiber-rich Food Intake in Relation to Risk of Stroke in Male Smokers." European Journal of Clinical Nutrition, vol. 63, no. 8, 2009, pp. 1016-24.
    Larsson SC, Männistö S, Virtanen MJ, et al. Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers. Eur J Clin Nutr. 2009;63(8):1016-24.
    Larsson, S. C., Männistö, S., Virtanen, M. J., Kontto, J., Albanes, D., & Virtamo, J. (2009). Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers. European Journal of Clinical Nutrition, 63(8), pp. 1016-24. doi:10.1038/ejcn.2009.16.
    Larsson SC, et al. Dietary Fiber and Fiber-rich Food Intake in Relation to Risk of Stroke in Male Smokers. Eur J Clin Nutr. 2009;63(8):1016-24. PubMed PMID: 19319150.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fiber and fiber-rich food intake in relation to risk of stroke in male smokers. AU - Larsson,S C, AU - Männistö,S, AU - Virtanen,M J, AU - Kontto,J, AU - Albanes,D, AU - Virtamo,J, Y1 - 2009/03/25/ PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/10/16/medline SP - 1016 EP - 24 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 8 N2 - BACKGROUND/OBJECTIVES: There is convincing evidence that a high dietary fiber intake may lower the risk of coronary heart disease. However, the role of fiber in the prevention of stroke is unclear. We examined the associations of dietary fiber and fiber-rich food intake with risk of stroke within the Alpha-tocopherol, Beta-carotene Cancer Prevention Study. SUBJECTS/METHODS: Between 1985 and 1988, 26,556 Finnish male smokers aged 50-69 years, who had no history of stroke, completed a dietary questionnaire. During a mean follow-up of 13.6 years, 2702 cerebral infarctions, 383 intracerebral hemorrhages and 196 subarachnoid hemorrhages were ascertained. RESULTS: After adjustment for cardiovascular risk factors and folate and magnesium intakes, there was no significant association between intake of total fiber, water-soluble fiber, water-insoluble fiber, or fiber derived from fruit or cereal sources and risk of any stroke subtype. Vegetable fiber intake, as well as the consumption of fruit, vegetables and cereals, was inversely associated with the risk of cerebral infarction; the multivariate relative risks for the highest quintile of intake as compared with the lowest were 0.86 (95% confidence interval (CI): 0.76-0.99) for vegetable fiber, 0.82 (95% CI: 0.73-0.93) for fruit, 0.75 (95% CI: 0.66-0.85) for vegetables and 0.87 (95% CI: 0.74-1.03) for cereals. Vegetable consumption was inversely associated with risk of subarachnoid hemorrhage (relative risk for highest versus lowest quintile: 0.62; 95% CI: 0.40-0.98), and cereal consumption was inversely associated with risk of intracerebral hemorrhage (relative risk: 0.64; 95% CI: 0.41-1.01). CONCLUSIONS: These findings suggest a beneficial effect of the consumption of fruits, vegetables and cereals on stroke risk. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19319150/Dietary_fiber_and_fiber_rich_food_intake_in_relation_to_risk_of_stroke_in_male_smokers_ L2 - http://dx.doi.org/10.1038/ejcn.2009.16 DB - PRIME DP - Unbound Medicine ER -