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Demographic and risk factors in patients with head and neck tumors.
J Med Virol. 2009 May; 81(5):878-87.JM

Abstract

The association between human papillomavirus (HPV) infection and the development of head and neck cancer has been documented recently. In this study on 86 head and neck cancer patients and 124 controls, data regarding demographics, behavioral risk factors, and risks related to HPV exposure were collected. HPV detection was carried out using polymerase chain reaction in the tumors and in oral exfoliated cells, and HPV typing by a reverse line blot assay specific for 37 HPV types. Sera were tested by an enzyme-linked immunosorbent assay specific for HPV proteins. Head and neck cancer cases report significantly more oral-anal contact (P = 0.02) and tobacco and alcohol use than controls (P = 0.001; P = 0.02, respectively). High-risk HPV DNA was detected in 43% of oral washings of cases and 4% of controls (P < 0.0001). The association between the presence of high-risk HPV DNA in oral exfoliated cells and in tumor tissues was statistically significant (adjusted P < 0.0001). The prevalence of HPV-specific antibodies was significantly higher in cases than in controls (adjusted P < 0.0001). These results provide epidemiological and immunological evidence for HR HPV as a strong risk factor (OR = 44.3, P < 0.0001) for head and neck cancer, even after controlling for age, tobacco and alcohol use. The detection of high-risk HPV DNA in oral exfoliated cells and HPV-specific antibodies in serum can be considered as clinically relevant surrogate markers for the presence of a HPV-associated head and neck cancer, with a high sensitivity (83%) and specificity (88%).

Authors+Show Affiliations

Department of Experimental Virology, Institute of Haematology and Blood Transfusion, Prague, Czech Republic. rutach@uhkt.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19319944

Citation

Tachezy, Ruth, et al. "Demographic and Risk Factors in Patients With Head and Neck Tumors." Journal of Medical Virology, vol. 81, no. 5, 2009, pp. 878-87.
Tachezy R, Klozar J, Rubenstein L, et al. Demographic and risk factors in patients with head and neck tumors. J Med Virol. 2009;81(5):878-87.
Tachezy, R., Klozar, J., Rubenstein, L., Smith, E., Saláková, M., Smahelová, J., Ludvíková, V., Rotnáglová, E., Kodet, R., & Hamsíková, E. (2009). Demographic and risk factors in patients with head and neck tumors. Journal of Medical Virology, 81(5), 878-87. https://doi.org/10.1002/jmv.21470
Tachezy R, et al. Demographic and Risk Factors in Patients With Head and Neck Tumors. J Med Virol. 2009;81(5):878-87. PubMed PMID: 19319944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Demographic and risk factors in patients with head and neck tumors. AU - Tachezy,Ruth, AU - Klozar,Jan, AU - Rubenstein,Linda, AU - Smith,Elaine, AU - Saláková,Martina, AU - Smahelová,Jana, AU - Ludvíková,Viera, AU - Rotnáglová,Eliska, AU - Kodet,Roman, AU - Hamsíková,Eva, PY - 2009/3/26/entrez PY - 2009/3/26/pubmed PY - 2009/5/6/medline SP - 878 EP - 87 JF - Journal of medical virology JO - J. Med. Virol. VL - 81 IS - 5 N2 - The association between human papillomavirus (HPV) infection and the development of head and neck cancer has been documented recently. In this study on 86 head and neck cancer patients and 124 controls, data regarding demographics, behavioral risk factors, and risks related to HPV exposure were collected. HPV detection was carried out using polymerase chain reaction in the tumors and in oral exfoliated cells, and HPV typing by a reverse line blot assay specific for 37 HPV types. Sera were tested by an enzyme-linked immunosorbent assay specific for HPV proteins. Head and neck cancer cases report significantly more oral-anal contact (P = 0.02) and tobacco and alcohol use than controls (P = 0.001; P = 0.02, respectively). High-risk HPV DNA was detected in 43% of oral washings of cases and 4% of controls (P < 0.0001). The association between the presence of high-risk HPV DNA in oral exfoliated cells and in tumor tissues was statistically significant (adjusted P < 0.0001). The prevalence of HPV-specific antibodies was significantly higher in cases than in controls (adjusted P < 0.0001). These results provide epidemiological and immunological evidence for HR HPV as a strong risk factor (OR = 44.3, P < 0.0001) for head and neck cancer, even after controlling for age, tobacco and alcohol use. The detection of high-risk HPV DNA in oral exfoliated cells and HPV-specific antibodies in serum can be considered as clinically relevant surrogate markers for the presence of a HPV-associated head and neck cancer, with a high sensitivity (83%) and specificity (88%). SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/19319944/Demographic_and_risk_factors_in_patients_with_head_and_neck_tumors_ L2 - https://doi.org/10.1002/jmv.21470 DB - PRIME DP - Unbound Medicine ER -