Tags

Type your tag names separated by a space and hit enter

Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers.
Am J Clin Nutr. 2009 May; 89(5):1321-7.AJ

Abstract

BACKGROUND

High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers. However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis.

OBJECTIVE

We investigated the effect of vitamin D on weight loss and traditional and nontraditional cardiovascular disease risk markers in overweight subjects.

DESIGN

Healthy overweight subjects (n = 200) with mean 25(OH)D concentrations of 30 nmol/L (12 ng/mL) received vitamin D (83 microg/d) or placebo in a double-blind manner for 12 mo while participating in a weight-reduction program.

RESULTS

Weight loss was not affected significantly by vitamin D supplementation (-5.7 +/- 5.8 kg) or placebo (-6.4 +/- 5.6 kg). However, mean 25(OH)D and calcitriol concentrations increased by 55.5 nmol/L and 40.0 pmol/L, respectively, in the vitamin D group but by only 11.8 nmol/L and 9.3 pmol/L, respectively, in the placebo group (P < 0.001), whereas a more pronounced decrease occurred in the vitamin D group than in the placebo group in blood concentrations of parathyroid hormone (-26.5% compared with -18.7%; P = 0.014), triglycerides (-13.5% compared with +3.0%; P < 0.001), and the inflammation marker tumor necrosis factor-alpha (-10.2% compared with -3.2%; P = 0.049). The beneficial biochemical effects were independent of the loss in body weight, fat mass, and sex. However, compared with placebo, vitamin D supplementation also increased LDL-cholesterol concentrations (+5.4% compared with -2.5%; P < 0.001).

CONCLUSIONS

The results indicate that a vitamin D supplement of 83 microg/d does not adversely affect weight loss and is able to significantly improve several cardiovascular disease risk markers in overweight subjects with inadequate vitamin D status participating in a weight-reduction program. This trial was registered at clinicaltrials.gov as NCT00493012.

Authors+Show Affiliations

Klinik für Thorax- und Kardiovaskularchirurgie and Institut für Laboratoriums- und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universität Bochum, Bad Oeynhausen, Germany. azittermann@hdz-nrw.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19321573

Citation

Zittermann, Armin, et al. "Vitamin D Supplementation Enhances the Beneficial Effects of Weight Loss On Cardiovascular Disease Risk Markers." The American Journal of Clinical Nutrition, vol. 89, no. 5, 2009, pp. 1321-7.
Zittermann A, Frisch S, Berthold HK, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr. 2009;89(5):1321-7.
Zittermann, A., Frisch, S., Berthold, H. K., Götting, C., Kuhn, J., Kleesiek, K., Stehle, P., Koertke, H., & Koerfer, R. (2009). Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. The American Journal of Clinical Nutrition, 89(5), 1321-7. https://doi.org/10.3945/ajcn.2008.27004
Zittermann A, et al. Vitamin D Supplementation Enhances the Beneficial Effects of Weight Loss On Cardiovascular Disease Risk Markers. Am J Clin Nutr. 2009;89(5):1321-7. PubMed PMID: 19321573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. AU - Zittermann,Armin, AU - Frisch,Sabine, AU - Berthold,Heiner K, AU - Götting,Christian, AU - Kuhn,Joachim, AU - Kleesiek,Knut, AU - Stehle,Peter, AU - Koertke,Heinrich, AU - Koerfer,Reiner, Y1 - 2009/03/25/ PY - 2009/3/27/entrez PY - 2009/3/27/pubmed PY - 2009/5/15/medline SP - 1321 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 89 IS - 5 N2 - BACKGROUND: High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers. However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis. OBJECTIVE: We investigated the effect of vitamin D on weight loss and traditional and nontraditional cardiovascular disease risk markers in overweight subjects. DESIGN: Healthy overweight subjects (n = 200) with mean 25(OH)D concentrations of 30 nmol/L (12 ng/mL) received vitamin D (83 microg/d) or placebo in a double-blind manner for 12 mo while participating in a weight-reduction program. RESULTS: Weight loss was not affected significantly by vitamin D supplementation (-5.7 +/- 5.8 kg) or placebo (-6.4 +/- 5.6 kg). However, mean 25(OH)D and calcitriol concentrations increased by 55.5 nmol/L and 40.0 pmol/L, respectively, in the vitamin D group but by only 11.8 nmol/L and 9.3 pmol/L, respectively, in the placebo group (P < 0.001), whereas a more pronounced decrease occurred in the vitamin D group than in the placebo group in blood concentrations of parathyroid hormone (-26.5% compared with -18.7%; P = 0.014), triglycerides (-13.5% compared with +3.0%; P < 0.001), and the inflammation marker tumor necrosis factor-alpha (-10.2% compared with -3.2%; P = 0.049). The beneficial biochemical effects were independent of the loss in body weight, fat mass, and sex. However, compared with placebo, vitamin D supplementation also increased LDL-cholesterol concentrations (+5.4% compared with -2.5%; P < 0.001). CONCLUSIONS: The results indicate that a vitamin D supplement of 83 microg/d does not adversely affect weight loss and is able to significantly improve several cardiovascular disease risk markers in overweight subjects with inadequate vitamin D status participating in a weight-reduction program. This trial was registered at clinicaltrials.gov as NCT00493012. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19321573/Vitamin_D_supplementation_enhances_the_beneficial_effects_of_weight_loss_on_cardiovascular_disease_risk_markers_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.27004 DB - PRIME DP - Unbound Medicine ER -