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Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae).
Z Naturforsch C J Biosci. 2009 Jan-Feb; 64(1-2):56-62.ZN

Abstract

n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities. The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S,4'S)-3'-acetoxy-4'-angeloyloxy-3',4'-dihydroseselin (2), (+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'-dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, Tandogan 06100, Ankara, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19323267

Citation

Tosun, Alev, et al. "Anti-inflammatory and Antinociceptive Activity of Coumarins From Seseli Gummiferum Subsp. Corymbosum (Apiaceae)." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 64, no. 1-2, 2009, pp. 56-62.
Tosun A, Akkol EK, Yeşilada E. Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae). Z Naturforsch, C, J Biosci. 2009;64(1-2):56-62.
Tosun, A., Akkol, E. K., & Yeşilada, E. (2009). Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae). Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 64(1-2), 56-62.
Tosun A, Akkol EK, Yeşilada E. Anti-inflammatory and Antinociceptive Activity of Coumarins From Seseli Gummiferum Subsp. Corymbosum (Apiaceae). Z Naturforsch, C, J Biosci. 2009 Jan-Feb;64(1-2):56-62. PubMed PMID: 19323267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae). AU - Tosun,Alev, AU - Akkol,Esra Küpeli, AU - Yeşilada,Erdem, PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/4/28/medline SP - 56 EP - 62 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z. Naturforsch., C, J. Biosci. VL - 64 IS - 1-2 N2 - n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities. The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S,4'S)-3'-acetoxy-4'-angeloyloxy-3',4'-dihydroseselin (2), (+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'-dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay. SN - 0939-5075 UR - https://www.unboundmedicine.com/medline/citation/19323267/Anti_inflammatory_and_antinociceptive_activity_of_coumarins_from_Seseli_gummiferum_subsp__corymbosum__Apiaceae__ DB - PRIME DP - Unbound Medicine ER -