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Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: a 13-year retrospective cohort study.
Clin Infect Dis 2009; 48(9):1237-43CI

Abstract

BACKGROUND

This study investigated the incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis cases at a Canadian clinic that mainly serves men who have sex with men.

METHODS

All patients with pharyngeal N. gonorrhoeae and C. trachomatis infections detected from 1 January 1995 through 31 December 2007 were identified. Original and test-of-cure N. gonorrhoeae culture isolates were compared using antibiotic susceptibility testing and N. gonorrhoeae multiantigen sequence typing.

RESULTS

One hundred seventy-eight cases of pharyngeal N. gonorrhoeae infection and 97 cases of pharyngeal C. trachomatis infection were identified, primarily by culture methods. The mean incidence was 1.62 and 0.81 cases per 1000 visits per year for N. gonorrhoeae and C. trachomatis infection, respectively. Poisson regression modeling demonstrated a statistically significant surge of pharyngeal N. gonorrhoeae cases in 2007 after controlling for seasonal and long-term oscillation and long-term linear trends. Among patients with pharyngeal N. gonorrhoeae and C. trachomatis infection, 60.2% and 84.3%, respectively, would have been missed by relying on urine and urethral testing. Nine percent of patients with pharyngeal N. gonorrhoeae and 4.3% of patients with pharyngeal C. trachomatis infection who underwent test-of-cure procedures had at least 1 positive result. Antibiograms were not different in 8 of 10 pretreatment and posttreatment N. gonorrhoeae isolate pairs. N. gonorrhoeae multiantigen sequence typing results were identical in 2 of these cases. Public health records documented abstinence in both individuals.

CONCLUSIONS

Nine percent of cases with pharyngeal N. gonorrhoeae and 4.3% of cases with pharyngeal C. trachomatis infection that underwent tests of cure had positive results. Available typing results suggest antibiotic treatment failure rather than reinfection. Specific antibiotic treatment regimens for pharyngeal N. gonorrhoeae and C. trachomatis infections need to be developed and formally evaluated.

Authors+Show Affiliations

The Hospital for Sick Children, Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19323630

Citation

Ota, Kaede V., et al. "Incidence and Treatment Outcomes of Pharyngeal Neisseria Gonorrhoeae and Chlamydia Trachomatis Infections in Men Who Have Sex With Men: a 13-year Retrospective Cohort Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 48, no. 9, 2009, pp. 1237-43.
Ota KV, Fisman DN, Tamari IE, et al. Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: a 13-year retrospective cohort study. Clin Infect Dis. 2009;48(9):1237-43.
Ota, K. V., Fisman, D. N., Tamari, I. E., Smieja, M., Ng, L. K., Jones, K. E., ... Richardson, S. E. (2009). Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: a 13-year retrospective cohort study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 48(9), pp. 1237-43. doi:10.1086/597586.
Ota KV, et al. Incidence and Treatment Outcomes of Pharyngeal Neisseria Gonorrhoeae and Chlamydia Trachomatis Infections in Men Who Have Sex With Men: a 13-year Retrospective Cohort Study. Clin Infect Dis. 2009 May 1;48(9):1237-43. PubMed PMID: 19323630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis infections in men who have sex with men: a 13-year retrospective cohort study. AU - Ota,Kaede V, AU - Fisman,David N, AU - Tamari,Itamar E, AU - Smieja,Marek, AU - Ng,Lai-King, AU - Jones,Karen E, AU - Diprima,Alessandro, AU - Richardson,Susan E, PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/5/13/medline SP - 1237 EP - 43 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 48 IS - 9 N2 - BACKGROUND: This study investigated the incidence and treatment outcomes of pharyngeal Neisseria gonorrhoeae and Chlamydia trachomatis cases at a Canadian clinic that mainly serves men who have sex with men. METHODS: All patients with pharyngeal N. gonorrhoeae and C. trachomatis infections detected from 1 January 1995 through 31 December 2007 were identified. Original and test-of-cure N. gonorrhoeae culture isolates were compared using antibiotic susceptibility testing and N. gonorrhoeae multiantigen sequence typing. RESULTS: One hundred seventy-eight cases of pharyngeal N. gonorrhoeae infection and 97 cases of pharyngeal C. trachomatis infection were identified, primarily by culture methods. The mean incidence was 1.62 and 0.81 cases per 1000 visits per year for N. gonorrhoeae and C. trachomatis infection, respectively. Poisson regression modeling demonstrated a statistically significant surge of pharyngeal N. gonorrhoeae cases in 2007 after controlling for seasonal and long-term oscillation and long-term linear trends. Among patients with pharyngeal N. gonorrhoeae and C. trachomatis infection, 60.2% and 84.3%, respectively, would have been missed by relying on urine and urethral testing. Nine percent of patients with pharyngeal N. gonorrhoeae and 4.3% of patients with pharyngeal C. trachomatis infection who underwent test-of-cure procedures had at least 1 positive result. Antibiograms were not different in 8 of 10 pretreatment and posttreatment N. gonorrhoeae isolate pairs. N. gonorrhoeae multiantigen sequence typing results were identical in 2 of these cases. Public health records documented abstinence in both individuals. CONCLUSIONS: Nine percent of cases with pharyngeal N. gonorrhoeae and 4.3% of cases with pharyngeal C. trachomatis infection that underwent tests of cure had positive results. Available typing results suggest antibiotic treatment failure rather than reinfection. Specific antibiotic treatment regimens for pharyngeal N. gonorrhoeae and C. trachomatis infections need to be developed and formally evaluated. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/19323630/Incidence_and_treatment_outcomes_of_pharyngeal_Neisseria_gonorrhoeae_and_Chlamydia_trachomatis_infections_in_men_who_have_sex_with_men:_a_13_year_retrospective_cohort_study_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/597586 DB - PRIME DP - Unbound Medicine ER -