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Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels.
BMC Med Genet. 2009 Mar 26; 10:30.BM

Abstract

BACKGROUND

Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology.

METHODS

Data were collected using a questionnaire which was answered by 67 mutation carriers and 102 physicians from the southern Swedish health care region. The statements were related to colorectal cancer, heredity and surveillance and the physicians were also asked questions about cancer risks and surveillance strategies.

RESULTS

Both groups answered questions on colorectal cancer risk, surveillance and genetic testing well, whereas answers about inheritance and risks for HNPCC associated cancer were less accurate. Only half of the family members and one third of the physicians correctly estimated the risk to inherit an HNPCC predisposing mutation. Among family members, young age (<57 years), female sex and recent genetic counseling significantly correlated with better results. Physicians generally underestimated the risk of HNPCC associated cancers and three out of four suggested a later starting age for surveillance than recommended.

CONCLUSION

The finding of similar levels of knowledge about key features of HNPCC in at risk individuals and physicians reflect the challenge physicians face in keeping up to date on hereditary cancer and may have implications for the clinical management and professional relations with HNPCC family members.

Authors+Show Affiliations

Department of Oncology, Institute of Clinical Sciences, Lund University, Sweden. katarina.domanska@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19323816

Citation

Domanska, Katarina, et al. "Knowledge About Hereditary Nonpolyposis Colorectal Cancer; Mutation Carriers and Physicians at Equal Levels." BMC Medical Genetics, vol. 10, 2009, p. 30.
Domanska K, Carlsson C, Bendahl PO, et al. Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels. BMC Med Genet. 2009;10:30.
Domanska, K., Carlsson, C., Bendahl, P. O., & Nilbert, M. (2009). Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels. BMC Medical Genetics, 10, 30. https://doi.org/10.1186/1471-2350-10-30
Domanska K, et al. Knowledge About Hereditary Nonpolyposis Colorectal Cancer; Mutation Carriers and Physicians at Equal Levels. BMC Med Genet. 2009 Mar 26;10:30. PubMed PMID: 19323816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels. AU - Domanska,Katarina, AU - Carlsson,Christina, AU - Bendahl,Pär-Ola, AU - Nilbert,Mef, Y1 - 2009/03/26/ PY - 2008/12/26/received PY - 2009/03/26/accepted PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/4/30/medline SP - 30 EP - 30 JF - BMC medical genetics JO - BMC Med. Genet. VL - 10 N2 - BACKGROUND: Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology. METHODS: Data were collected using a questionnaire which was answered by 67 mutation carriers and 102 physicians from the southern Swedish health care region. The statements were related to colorectal cancer, heredity and surveillance and the physicians were also asked questions about cancer risks and surveillance strategies. RESULTS: Both groups answered questions on colorectal cancer risk, surveillance and genetic testing well, whereas answers about inheritance and risks for HNPCC associated cancer were less accurate. Only half of the family members and one third of the physicians correctly estimated the risk to inherit an HNPCC predisposing mutation. Among family members, young age (<57 years), female sex and recent genetic counseling significantly correlated with better results. Physicians generally underestimated the risk of HNPCC associated cancers and three out of four suggested a later starting age for surveillance than recommended. CONCLUSION: The finding of similar levels of knowledge about key features of HNPCC in at risk individuals and physicians reflect the challenge physicians face in keeping up to date on hereditary cancer and may have implications for the clinical management and professional relations with HNPCC family members. SN - 1471-2350 UR - https://www.unboundmedicine.com/medline/citation/19323816/Knowledge_about_hereditary_nonpolyposis_colorectal_cancer L2 - https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-10-30 DB - PRIME DP - Unbound Medicine ER -