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Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
Fertil Steril. 2010 Jun; 94(1):52-7.FS

Abstract

OBJECTIVE

To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers.

DESIGN

Patients with endometriosis before and after surgery were compared with control patients.

SETTING

University Hospital.

PATIENT(S)

Twenty-one healthy controls and 32 women with advanced endometriosis.

INTERVENTION(S)

In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy.

MAIN OUTCOME MEASURE(S)

Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery.

RESULT(S)

Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF.

CONCLUSION(S)

Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.

Authors+Show Affiliations

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19324337

Citation

Bourlev, Vladimir, et al. "Signs of Reduced Angiogenic Activity After Surgical Removal of Deeply Infiltrating Endometriosis." Fertility and Sterility, vol. 94, no. 1, 2010, pp. 52-7.
Bourlev V, Iljasova N, Adamyan L, et al. Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis. Fertil Steril. 2010;94(1):52-7.
Bourlev, V., Iljasova, N., Adamyan, L., Larsson, A., & Olovsson, M. (2010). Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis. Fertility and Sterility, 94(1), 52-7. https://doi.org/10.1016/j.fertnstert.2009.02.019
Bourlev V, et al. Signs of Reduced Angiogenic Activity After Surgical Removal of Deeply Infiltrating Endometriosis. Fertil Steril. 2010;94(1):52-7. PubMed PMID: 19324337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis. AU - Bourlev,Vladimir, AU - Iljasova,Natalia, AU - Adamyan,Leyla, AU - Larsson,Anders, AU - Olovsson,Matts, Y1 - 2009/03/25/ PY - 2008/09/16/received PY - 2009/01/26/revised PY - 2009/02/09/accepted PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2010/6/18/medline SP - 52 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 94 IS - 1 N2 - OBJECTIVE: To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers. DESIGN: Patients with endometriosis before and after surgery were compared with control patients. SETTING: University Hospital. PATIENT(S): Twenty-one healthy controls and 32 women with advanced endometriosis. INTERVENTION(S): In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy. MAIN OUTCOME MEASURE(S): Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery. RESULT(S): Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF. CONCLUSION(S): Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19324337/Signs_of_reduced_angiogenic_activity_after_surgical_removal_of_deeply_infiltrating_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)00377-X DB - PRIME DP - Unbound Medicine ER -