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Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal.
J Pediatr 2009; 155(1):51-5, 55.e1JPed

Abstract

OBJECTIVE

To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function.

STUDY DESIGN

Children with biopsy-proven CD (n = 324; female:male 2:1; mean age, 6.6 years) followed from 1 to 15 years, were retrospectively evaluated for AT at onset of CD and during GFD. Serum thyroid peroxidase and thyroglobulin antibodies (AbTPO, AbTG), thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid ultrasonography were considered. Age-matched Sardinian schoolchildren (n = 8040), previously evaluated for antithyroid antibodies and thyroid function, were used as controls.

RESULTS

Thirty-four patients with CD (10.5%) developed AT (female:male 4,5:1; mean age, 10.5 years), 11 at onset of CD and 23 during GFD, with a higher prevalence than controls (P = 2.9(-13)). Twenty-eight patients were euthyroid and 6 hypothyroid. AbTPO and/or AbTG persisted elevated for 2 to 9 years despite the GFD in 9 of 11 patients with AT at onset of CD.

CONCLUSIONS

AT is strongly associated with CD in Sardinian children, has an age of onset of 10.5 years, and appears to be gluten-independent. In children with CD with AT, the female:male bias reported in adult AT is present before puberty.

Authors+Show Affiliations

Pediatric Clinic II, Microcitemico Hospital ASL 8, Department of Biological Sciences and Biotechnology, University of Cagliari, Sardinia, Italy. ameloni@mcweb.unica.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19324373

Citation

Meloni, Antonella, et al. "Prevalence of Autoimmune Thyroiditis in Children With Celiac Disease and Effect of Gluten Withdrawal." The Journal of Pediatrics, vol. 155, no. 1, 2009, pp. 51-5, 55.e1.
Meloni A, Mandas C, Jores RD, et al. Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. J Pediatr. 2009;155(1):51-5, 55.e1.
Meloni, A., Mandas, C., Jores, R. D., & Congia, M. (2009). Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. The Journal of Pediatrics, 155(1), pp. 51-5, 55.e1. doi:10.1016/j.jpeds.2009.01.013.
Meloni A, et al. Prevalence of Autoimmune Thyroiditis in Children With Celiac Disease and Effect of Gluten Withdrawal. J Pediatr. 2009;155(1):51-5, 55.e1. PubMed PMID: 19324373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal. AU - Meloni,Antonella, AU - Mandas,Chiara, AU - Jores,Rita Désirée, AU - Congia,Mauro, Y1 - 2009/03/25/ PY - 2008/08/29/received PY - 2008/11/24/revised PY - 2009/01/08/accepted PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/7/23/medline SP - 51-5, 55.e1 JF - The Journal of pediatrics JO - J. Pediatr. VL - 155 IS - 1 N2 - OBJECTIVE: To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function. STUDY DESIGN: Children with biopsy-proven CD (n = 324; female:male 2:1; mean age, 6.6 years) followed from 1 to 15 years, were retrospectively evaluated for AT at onset of CD and during GFD. Serum thyroid peroxidase and thyroglobulin antibodies (AbTPO, AbTG), thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid ultrasonography were considered. Age-matched Sardinian schoolchildren (n = 8040), previously evaluated for antithyroid antibodies and thyroid function, were used as controls. RESULTS: Thirty-four patients with CD (10.5%) developed AT (female:male 4,5:1; mean age, 10.5 years), 11 at onset of CD and 23 during GFD, with a higher prevalence than controls (P = 2.9(-13)). Twenty-eight patients were euthyroid and 6 hypothyroid. AbTPO and/or AbTG persisted elevated for 2 to 9 years despite the GFD in 9 of 11 patients with AT at onset of CD. CONCLUSIONS: AT is strongly associated with CD in Sardinian children, has an age of onset of 10.5 years, and appears to be gluten-independent. In children with CD with AT, the female:male bias reported in adult AT is present before puberty. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/19324373/Prevalence_of_autoimmune_thyroiditis_in_children_with_celiac_disease_and_effect_of_gluten_withdrawal_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(09)00012-2 DB - PRIME DP - Unbound Medicine ER -