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Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome.
Aging Male 2009; 12(1):29-34AM

Abstract

INTRODUCTION

The purpose of this study was to investigate the association between severity of lower urinary tract symptoms (LUTS), erectile dysfunction (ED) and metabolic syndrome.

METHODS

Our study population included a consecutive series of 190 patients with LUTS (International Prostate Symptom Score-IPSS >7) with or without manifestations of the metabolic syndrome. The diagnoses of diabetes mellitus and hypertension were obtained from the patient's medical history. Data on blood pressure, waist measure, body height and weight were collected and body mass index were calculated. Patients were assessed based on the International Index of Erectile Function (IIEF) for ED and IPSS and IPSS-Quality of Life for LUTS. Blood samples were drawn from fasting patients to determine, fasting blood glucose (FBG), triglycerides, HDL-cholesterol and serum total testosterone levels.

RESULTS

In severe LUTS patient group, IIEF erectile function domain scores were significantly lower than moderate LUTS patient group (p < 0.05). Multiple logistic regression analysis confirmed that presence of ED was the most predictor of severe LUTS. The prevalence of metabolic syndrome was higher in patients with severe LUTS (26%vs. 46%, p = 0.009). The severe form of the LUTS was significantly correlated with waist circumference >102 cm (p < 0.05), blood pressure > or =130/85 mmHg (p < 0.05) and FBG >110 mg/dl (p < 0.01).

CONCLUSION

Obesity, high plasma level of FBG and hypertension constitute risk factors for the development of severe LUTS. Metabolic syndrome may play a key role in the pathogenesis in both ED and LUTS. Presence of ED is the most predictor of severe LUTS.

Authors+Show Affiliations

Department of Urology, Dokuz Eylul University, School of Medicine, Inciralti, Izmir, Turkey. omer.demir@deu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19326294

Citation

Demir, Omer, et al. "Association Between Severity of Lower Urinary Tract Symptoms, Erectile Dysfunction and Metabolic Syndrome." The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, vol. 12, no. 1, 2009, pp. 29-34.
Demir O, Akgul K, Akar Z, et al. Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome. Aging Male. 2009;12(1):29-34.
Demir, O., Akgul, K., Akar, Z., Cakmak, O., Ozdemir, I., Bolukbasi, A., ... Gumus, B. H. (2009). Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome. The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 12(1), pp. 29-34. doi:10.1080/13685530902777425.
Demir O, et al. Association Between Severity of Lower Urinary Tract Symptoms, Erectile Dysfunction and Metabolic Syndrome. Aging Male. 2009;12(1):29-34. PubMed PMID: 19326294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome. AU - Demir,Omer, AU - Akgul,Korhan, AU - Akar,Zafer, AU - Cakmak,Ozgur, AU - Ozdemir,Ismail, AU - Bolukbasi,Ahmet, AU - Can,Ertan, AU - Gumus,Bilal H, PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/5/30/medline SP - 29 EP - 34 JF - The aging male : the official journal of the International Society for the Study of the Aging Male JO - Aging Male VL - 12 IS - 1 N2 - INTRODUCTION: The purpose of this study was to investigate the association between severity of lower urinary tract symptoms (LUTS), erectile dysfunction (ED) and metabolic syndrome. METHODS: Our study population included a consecutive series of 190 patients with LUTS (International Prostate Symptom Score-IPSS >7) with or without manifestations of the metabolic syndrome. The diagnoses of diabetes mellitus and hypertension were obtained from the patient's medical history. Data on blood pressure, waist measure, body height and weight were collected and body mass index were calculated. Patients were assessed based on the International Index of Erectile Function (IIEF) for ED and IPSS and IPSS-Quality of Life for LUTS. Blood samples were drawn from fasting patients to determine, fasting blood glucose (FBG), triglycerides, HDL-cholesterol and serum total testosterone levels. RESULTS: In severe LUTS patient group, IIEF erectile function domain scores were significantly lower than moderate LUTS patient group (p < 0.05). Multiple logistic regression analysis confirmed that presence of ED was the most predictor of severe LUTS. The prevalence of metabolic syndrome was higher in patients with severe LUTS (26%vs. 46%, p = 0.009). The severe form of the LUTS was significantly correlated with waist circumference >102 cm (p < 0.05), blood pressure > or =130/85 mmHg (p < 0.05) and FBG >110 mg/dl (p < 0.01). CONCLUSION: Obesity, high plasma level of FBG and hypertension constitute risk factors for the development of severe LUTS. Metabolic syndrome may play a key role in the pathogenesis in both ED and LUTS. Presence of ED is the most predictor of severe LUTS. SN - 1473-0790 UR - https://www.unboundmedicine.com/medline/citation/19326294/Association_between_severity_of_lower_urinary_tract_symptoms_erectile_dysfunction_and_metabolic_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/13685530902777425 DB - PRIME DP - Unbound Medicine ER -