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Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study.

Abstract

We investigated the association of dietary alpha-tocopherol, gamma-tocopherol and supplemental vitamin E intake with the risk of esophageal squamous cell carcinoma (n = 158), esophageal adenocarcinoma (n = 382), gastric cardia adenocarcinoma (n = 320) and gastric noncardia adenocarcinoma (GNCA; n = 327) in the NIH-AARP Diet and Health Study, a cohort of approximately 500,000 people. Data on dietary and supplemental vitamin E intake were collected using a validated questionnaire at baseline and were analyzed using Cox regression models. Intakes were analyzed as continuous variables and as quartiles. For dietary alpha-tocopherol, we found some evidence of association with decreased esophageal squamous cell carcinoma and increased esophageal adenocarcinoma risk in the continuous analyses, with adjusted hazard ratios and 95% confidence intervals of 0.90 (0.81-0.99) and 1.05 (1.00-1.11), respectively, per 1.17 mg (half the interquartile range) increased intake. However, in quartile analyses, the p value for trend was nonsignificant for both these cancers. There was no association between dietary alpha-tocopherol and gastric cardia adenocarcinoma or GNCA. We observed no statistically significant associations with gamma-tocopherol. For supplemental vitamin E, the results were mainly null, except for a significantly lower risk of GNCA with higher doses of supplemental vitamin E. An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015.

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  • Authors+Show Affiliations

    ,

    NEB/DCEG, National Cancer Institute, Bethesda, MD 20892-7232, USA.

    , , , , , , ,

    Source

    International journal of cancer 125:1 2009 Jul 01 pg 165-70

    MeSH

    Adenocarcinoma
    Aged
    Carcinoma, Squamous Cell
    Cohort Studies
    Diet
    Esophageal Neoplasms
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    National Institutes of Health (U.S.)
    Prospective Studies
    Risk Factors
    Stomach Neoplasms
    Surveys and Questionnaires
    Tocopherols
    United States
    alpha-Tocopherol
    gamma-Tocopherol

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19326432

    Citation

    Carman, Sarah, et al. "Vitamin E Intake and Risk of Esophageal and Gastric Cancers in the NIH-AARP Diet and Health Study." International Journal of Cancer, vol. 125, no. 1, 2009, pp. 165-70.
    Carman S, Kamangar F, Freedman ND, et al. Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study. Int J Cancer. 2009;125(1):165-70.
    Carman, S., Kamangar, F., Freedman, N. D., Wright, M. E., Dawsey, S. M., Dixon, L. B., ... Abnet, C. C. (2009). Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study. International Journal of Cancer, 125(1), pp. 165-70. doi:10.1002/ijc.24342.
    Carman S, et al. Vitamin E Intake and Risk of Esophageal and Gastric Cancers in the NIH-AARP Diet and Health Study. Int J Cancer. 2009 Jul 1;125(1):165-70. PubMed PMID: 19326432.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study. AU - Carman,Sarah, AU - Kamangar,Farin, AU - Freedman,Neal D, AU - Wright,Margaret E, AU - Dawsey,Sanford M, AU - Dixon,L Beth, AU - Subar,Amy, AU - Schatzkin,Arthur, AU - Abnet,Christian C, PY - 2009/3/28/entrez PY - 2009/3/28/pubmed PY - 2009/5/29/medline SP - 165 EP - 70 JF - International journal of cancer JO - Int. J. Cancer VL - 125 IS - 1 N2 - We investigated the association of dietary alpha-tocopherol, gamma-tocopherol and supplemental vitamin E intake with the risk of esophageal squamous cell carcinoma (n = 158), esophageal adenocarcinoma (n = 382), gastric cardia adenocarcinoma (n = 320) and gastric noncardia adenocarcinoma (GNCA; n = 327) in the NIH-AARP Diet and Health Study, a cohort of approximately 500,000 people. Data on dietary and supplemental vitamin E intake were collected using a validated questionnaire at baseline and were analyzed using Cox regression models. Intakes were analyzed as continuous variables and as quartiles. For dietary alpha-tocopherol, we found some evidence of association with decreased esophageal squamous cell carcinoma and increased esophageal adenocarcinoma risk in the continuous analyses, with adjusted hazard ratios and 95% confidence intervals of 0.90 (0.81-0.99) and 1.05 (1.00-1.11), respectively, per 1.17 mg (half the interquartile range) increased intake. However, in quartile analyses, the p value for trend was nonsignificant for both these cancers. There was no association between dietary alpha-tocopherol and gastric cardia adenocarcinoma or GNCA. We observed no statistically significant associations with gamma-tocopherol. For supplemental vitamin E, the results were mainly null, except for a significantly lower risk of GNCA with higher doses of supplemental vitamin E. An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19326432/Vitamin_E_intake_and_risk_of_esophageal_and_gastric_cancers_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://doi.org/10.1002/ijc.24342 DB - PRIME DP - Unbound Medicine ER -