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Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats.
Food Chem Toxicol. 2009 Jun; 47(6):1385-92.FC

Abstract

Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. CCl(4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl(4)-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl(4). These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl(4)-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation.

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Publisher Full Text

Authors+Show Affiliations

Tung YT
School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan.
Wu JH
No affiliation info available
Huang CC
No affiliation info available
Peng HC
No affiliation info available
Chen YL
No affiliation info available
Yang SC
No affiliation info available
Chang ST
No affiliation info available

MeSH

AcaciaAnimalsAntioxidantsBlotting, WesternCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryCytochrome P-450 CYP2E1ErythrocytesGallic AcidLipid PeroxidationLiverLiver Function TestsMalePlant BarkPlant ExtractsRatsRats, Sprague-DawleyThiobarbituric Acid Reactive Substances

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19327382

Citation

Tung, Yu-Tang, et al. "Protective Effect of Acacia Confusa Bark Extract and Its Active Compound Gallic Acid Against Carbon Tetrachloride-induced Chronic Liver Injury in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 6, 2009, pp. 1385-92.
Tung YT, Wu JH, Huang CC, et al. Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009;47(6):1385-92.
Tung, Y. T., Wu, J. H., Huang, C. C., Peng, H. C., Chen, Y. L., Yang, S. C., & Chang, S. T. (2009). Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(6), 1385-92. https://doi.org/10.1016/j.fct.2009.03.021
Tung YT, et al. Protective Effect of Acacia Confusa Bark Extract and Its Active Compound Gallic Acid Against Carbon Tetrachloride-induced Chronic Liver Injury in Rats. Food Chem Toxicol. 2009;47(6):1385-92. PubMed PMID: 19327382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats. AU - Tung,Yu-Tang, AU - Wu,Jyh-Horng, AU - Huang,Chi-Chang, AU - Peng,Hsiang-Chi, AU - Chen,Ya-Ling, AU - Yang,Suh-Ching, AU - Chang,Shang-Tzen, Y1 - 2009/03/25/ PY - 2008/09/17/received PY - 2009/03/04/revised PY - 2009/03/17/accepted PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/7/17/medline SP - 1385 EP - 92 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 6 N2 - Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. CCl(4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl(4)-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl(4). These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl(4)-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19327382/Protective_effect_of_Acacia_confusa_bark_extract_and_its_active_compound_gallic_acid_against_carbon_tetrachloride_induced_chronic_liver_injury_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00129-X DB - PRIME DP - Unbound Medicine ER -