Tags

Type your tag names separated by a space and hit enter

Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration.
Am J Ophthalmol. 2009 Jul; 148(1):83-9.e1.AJ

Abstract

PURPOSE

To evaluate the correlation between visual outcome and foveal photoreceptor integrity after successful treatment of eyes with neovascular age-related macular degeneration (AMD).

DESIGN

Retrospective chart review.

METHODS

We retrospectively studied the medical records of 51 eyes of 51 patients with neovascular AMD who were treated successfully with photodynamic therapy (PDT). All eyes were followed-up for more than 24 months after the initial treatment. Using spectral-domain optical coherence tomography, the status of the inner segment and outer segment (IS/OS) photoreceptor junction was assessed as a hallmark of the integrity of the foveal photoreceptor layer.

RESULTS

At the final visit, no eyes showed an exudative change. A complete or discontinuous IS/OS line was detected beneath the fovea in 8 (15.7%) and 25 (29.4%) eyes, respectively, whereas 28 (54.9%) had no IS/OS line. Eyes with a continuous or discontinuous IS/OS line beneath the fovea had better final visual acuity (VA) than did eyes without an IS/OS line (P < .001, respectively). Of the 51 eyes, 36 showed polypoidal choroidal vasculopathy (PCV), whereas 15 were diagnosed as having typical AMD without PCV. Visual outcome was significantly better in eyes with PCV (P = .026). Most eyes (13/15; 86.7%) with typical AMD had no IS/OS line at the final visit, whereas only 13 (36.1%) of the 36 eyes with PCV had no IS/OS line beneath the fovea.

CONCLUSIONS

Integrity of the photoreceptor layer beneath the fovea is associated with the final VA in neovascular AMD after successful PDT.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19327745

Citation

Hayashi, Hisako, et al. "Association Between Foveal Photoreceptor Integrity and Visual Outcome in Neovascular Age-related Macular Degeneration." American Journal of Ophthalmology, vol. 148, no. 1, 2009, pp. 83-9.e1.
Hayashi H, Yamashiro K, Tsujikawa A, et al. Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration. Am J Ophthalmol. 2009;148(1):83-9.e1.
Hayashi, H., Yamashiro, K., Tsujikawa, A., Ota, M., Otani, A., & Yoshimura, N. (2009). Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration. American Journal of Ophthalmology, 148(1), 83-e1. https://doi.org/10.1016/j.ajo.2009.01.017
Hayashi H, et al. Association Between Foveal Photoreceptor Integrity and Visual Outcome in Neovascular Age-related Macular Degeneration. Am J Ophthalmol. 2009;148(1):83-9.e1. PubMed PMID: 19327745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration. AU - Hayashi,Hisako, AU - Yamashiro,Kenji, AU - Tsujikawa,Akitaka, AU - Ota,Masafumi, AU - Otani,Atsushi, AU - Yoshimura,Nagahisa, Y1 - 2009/03/27/ PY - 2008/07/04/received PY - 2009/01/19/revised PY - 2009/01/22/accepted PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/7/2/medline SP - 83 EP - 9.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 148 IS - 1 N2 - PURPOSE: To evaluate the correlation between visual outcome and foveal photoreceptor integrity after successful treatment of eyes with neovascular age-related macular degeneration (AMD). DESIGN: Retrospective chart review. METHODS: We retrospectively studied the medical records of 51 eyes of 51 patients with neovascular AMD who were treated successfully with photodynamic therapy (PDT). All eyes were followed-up for more than 24 months after the initial treatment. Using spectral-domain optical coherence tomography, the status of the inner segment and outer segment (IS/OS) photoreceptor junction was assessed as a hallmark of the integrity of the foveal photoreceptor layer. RESULTS: At the final visit, no eyes showed an exudative change. A complete or discontinuous IS/OS line was detected beneath the fovea in 8 (15.7%) and 25 (29.4%) eyes, respectively, whereas 28 (54.9%) had no IS/OS line. Eyes with a continuous or discontinuous IS/OS line beneath the fovea had better final visual acuity (VA) than did eyes without an IS/OS line (P < .001, respectively). Of the 51 eyes, 36 showed polypoidal choroidal vasculopathy (PCV), whereas 15 were diagnosed as having typical AMD without PCV. Visual outcome was significantly better in eyes with PCV (P = .026). Most eyes (13/15; 86.7%) with typical AMD had no IS/OS line at the final visit, whereas only 13 (36.1%) of the 36 eyes with PCV had no IS/OS line beneath the fovea. CONCLUSIONS: Integrity of the photoreceptor layer beneath the fovea is associated with the final VA in neovascular AMD after successful PDT. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/19327745/Association_between_foveal_photoreceptor_integrity_and_visual_outcome_in_neovascular_age_related_macular_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(09)00067-1 DB - PRIME DP - Unbound Medicine ER -