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Strongyloidiasis--the most neglected of the neglected tropical diseases?
Trans R Soc Trop Med Hyg. 2009 Oct; 103(10):967-72.TR

Abstract

Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially life-threatening dissemination of larvae to all internal organs is found among individuals with compromised immune system functions. This paper provides an overview of the current state of the art in relation to diagnostic methods for detecting the infection, the morbidity caused by the infection and the recommended treatment. It further discusses some of the reasons why this infection is so neglected and the consequence of this for the estimated global prevalence. The paper finally points to the gaps in our knowledge and future research needs related to this infection. As Strongyloides infections have the potential to develop into severe disease in certain population subgroups, untreated infections could cause serious problems in the community. Therefore, we need to carefully investigate this parasite in order to develop and implement effective control programmes.

Authors+Show Affiliations

DBL-Centre for Health Research and Development, University of Copenhagen, Copenhagen, Denmark. aol@life.ku.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19328508

Citation

Olsen, Annette, et al. "Strongyloidiasis--the Most Neglected of the Neglected Tropical Diseases?" Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 103, no. 10, 2009, pp. 967-72.
Olsen A, van Lieshout L, Marti H, et al. Strongyloidiasis--the most neglected of the neglected tropical diseases? Trans R Soc Trop Med Hyg. 2009;103(10):967-72.
Olsen, A., van Lieshout, L., Marti, H., Polderman, T., Polman, K., Steinmann, P., Stothard, R., Thybo, S., Verweij, J. J., & Magnussen, P. (2009). Strongyloidiasis--the most neglected of the neglected tropical diseases? Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(10), 967-72. https://doi.org/10.1016/j.trstmh.2009.02.013
Olsen A, et al. Strongyloidiasis--the Most Neglected of the Neglected Tropical Diseases. Trans R Soc Trop Med Hyg. 2009;103(10):967-72. PubMed PMID: 19328508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strongyloidiasis--the most neglected of the neglected tropical diseases? AU - Olsen,Annette, AU - van Lieshout,Lisette, AU - Marti,Hanspeter, AU - Polderman,Ton, AU - Polman,Katja, AU - Steinmann,Peter, AU - Stothard,Russell, AU - Thybo,Søren, AU - Verweij,Jaco J, AU - Magnussen,Pascal, Y1 - 2009/03/27/ PY - 2008/12/29/received PY - 2009/02/17/revised PY - 2009/02/17/accepted PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2010/11/3/medline SP - 967 EP - 72 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans. R. Soc. Trop. Med. Hyg. VL - 103 IS - 10 N2 - Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially life-threatening dissemination of larvae to all internal organs is found among individuals with compromised immune system functions. This paper provides an overview of the current state of the art in relation to diagnostic methods for detecting the infection, the morbidity caused by the infection and the recommended treatment. It further discusses some of the reasons why this infection is so neglected and the consequence of this for the estimated global prevalence. The paper finally points to the gaps in our knowledge and future research needs related to this infection. As Strongyloides infections have the potential to develop into severe disease in certain population subgroups, untreated infections could cause serious problems in the community. Therefore, we need to carefully investigate this parasite in order to develop and implement effective control programmes. SN - 1878-3503 UR - https://www.unboundmedicine.com/medline/citation/19328508/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(09)00053-4 DB - PRIME DP - Unbound Medicine ER -