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Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study.
Bioorg Med Chem Lett. 2009 May 01; 19(9):2551-4.BM

Abstract

Isoindolo[2,1-b]isoquinolinones 9a-i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cytotoxicities against three different tumor cell lines. A Surflex-dock docking study was performed to clarify the topoisomerase 1 inhibitory activity of 9d.

Authors+Show Affiliations

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19328687

Citation

Van, Hue Thi My, and Won-Jea Cho. "Structural Modification of 3-arylisoquinolines to Isoindolo[2,1-b]isoquinolinones for the Development of Novel Topoisomerase 1 Inhibitors With Molecular Docking Study." Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 9, 2009, pp. 2551-4.
Van HT, Cho WJ. Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study. Bioorg Med Chem Lett. 2009;19(9):2551-4.
Van, H. T., & Cho, W. J. (2009). Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study. Bioorganic & Medicinal Chemistry Letters, 19(9), 2551-4. https://doi.org/10.1016/j.bmcl.2009.03.042
Van HT, Cho WJ. Structural Modification of 3-arylisoquinolines to Isoindolo[2,1-b]isoquinolinones for the Development of Novel Topoisomerase 1 Inhibitors With Molecular Docking Study. Bioorg Med Chem Lett. 2009 May 1;19(9):2551-4. PubMed PMID: 19328687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study. AU - Van,Hue Thi My, AU - Cho,Won-Jea, Y1 - 2009/03/16/ PY - 2009/01/29/received PY - 2009/03/04/revised PY - 2009/03/07/accepted PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/8/22/medline SP - 2551 EP - 4 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 19 IS - 9 N2 - Isoindolo[2,1-b]isoquinolinones 9a-i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cytotoxicities against three different tumor cell lines. A Surflex-dock docking study was performed to clarify the topoisomerase 1 inhibitory activity of 9d. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/19328687/Structural_modification_of_3_arylisoquinolines_to_isoindolo[21_b]isoquinolinones_for_the_development_of_novel_topoisomerase_1_inhibitors_with_molecular_docking_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(09)00334-5 DB - PRIME DP - Unbound Medicine ER -