Tags

Type your tag names separated by a space and hit enter

Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection.
Transplant Proc 2009; 41(2):589-94TP

Abstract

BACKGROUND

End-stage liver disease due to hepatitis C viral (HCV) infection is the most common reason for liver transplantation. One of the major risk factors for infection with HCV is intravenous drug use (IVDU). The pretransplantation characteristics and outcome of liver transplantation in patients with chronic hepatitis C (CHC) infected after IVDU are poorly known.

METHODS

We performed a retrospective cohort study in patients with CHC who underwent liver transplantation between 1998 and 2002 in Belgium. Seven patients with and 60 patients without a history of IVDU were compared.

RESULTS

Patients with CHC infected after IVDU were primarily men, significantly younger, and affected more by genotype 2 or 3. There was no relapse in substance use. No patients required a second transplantation or developed surgical complications. Progression to fibrosis in the posttransplantation period seemed to be slower. Graft and patient survival, and compliance were similar in both groups.

CONCLUSIONS

Compared with patients in the non-IVDU group, patients with CHC infected after IVDU in complete remission have the same compliance, and patient and graft survival after liver transplantation. Therefore, patients with IVDU should not be excluded for liver transplantation because of HCV-induced cirrhosis.

Authors+Show Affiliations

ZOL Campus St.-Jan, Genk, Belgium. Geert.robaeys@zol.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19328933

Citation

Robaeys, G, et al. "Previous Intravenous Substance Use and Outcome of Liver Transplantation in Patients With Chronic Hepatitis C Infection." Transplantation Proceedings, vol. 41, no. 2, 2009, pp. 589-94.
Robaeys G, Nevens F, Stärkel P, et al. Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. Transplant Proc. 2009;41(2):589-94.
Robaeys, G., Nevens, F., Stärkel, P., Colle, I., Van Eyken, P., Bruckers, L., ... Buntinx, F. (2009). Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. Transplantation Proceedings, 41(2), pp. 589-94. doi:10.1016/j.transproceed.2009.01.003.
Robaeys G, et al. Previous Intravenous Substance Use and Outcome of Liver Transplantation in Patients With Chronic Hepatitis C Infection. Transplant Proc. 2009;41(2):589-94. PubMed PMID: 19328933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. AU - Robaeys,G, AU - Nevens,F, AU - Stärkel,P, AU - Colle,I, AU - Van Eyken,P, AU - Bruckers,L, AU - Van Ranst,M, AU - Buntinx,F, PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/7/30/medline SP - 589 EP - 94 JF - Transplantation proceedings JO - Transplant. Proc. VL - 41 IS - 2 N2 - BACKGROUND: End-stage liver disease due to hepatitis C viral (HCV) infection is the most common reason for liver transplantation. One of the major risk factors for infection with HCV is intravenous drug use (IVDU). The pretransplantation characteristics and outcome of liver transplantation in patients with chronic hepatitis C (CHC) infected after IVDU are poorly known. METHODS: We performed a retrospective cohort study in patients with CHC who underwent liver transplantation between 1998 and 2002 in Belgium. Seven patients with and 60 patients without a history of IVDU were compared. RESULTS: Patients with CHC infected after IVDU were primarily men, significantly younger, and affected more by genotype 2 or 3. There was no relapse in substance use. No patients required a second transplantation or developed surgical complications. Progression to fibrosis in the posttransplantation period seemed to be slower. Graft and patient survival, and compliance were similar in both groups. CONCLUSIONS: Compared with patients in the non-IVDU group, patients with CHC infected after IVDU in complete remission have the same compliance, and patient and graft survival after liver transplantation. Therefore, patients with IVDU should not be excluded for liver transplantation because of HCV-induced cirrhosis. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/19328933/Previous_intravenous_substance_use_and_outcome_of_liver_transplantation_in_patients_with_chronic_hepatitis_C_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(09)00004-9 DB - PRIME DP - Unbound Medicine ER -