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Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection.

Abstract

BACKGROUND

End-stage liver disease due to hepatitis C viral (HCV) infection is the most common reason for liver transplantation. One of the major risk factors for infection with HCV is intravenous drug use (IVDU). The pretransplantation characteristics and outcome of liver transplantation in patients with chronic hepatitis C (CHC) infected after IVDU are poorly known.

METHODS

We performed a retrospective cohort study in patients with CHC who underwent liver transplantation between 1998 and 2002 in Belgium. Seven patients with and 60 patients without a history of IVDU were compared.

RESULTS

Patients with CHC infected after IVDU were primarily men, significantly younger, and affected more by genotype 2 or 3. There was no relapse in substance use. No patients required a second transplantation or developed surgical complications. Progression to fibrosis in the posttransplantation period seemed to be slower. Graft and patient survival, and compliance were similar in both groups.

CONCLUSIONS

Compared with patients in the non-IVDU group, patients with CHC infected after IVDU in complete remission have the same compliance, and patient and graft survival after liver transplantation. Therefore, patients with IVDU should not be excluded for liver transplantation because of HCV-induced cirrhosis.

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  • Authors+Show Affiliations

    ,

    ZOL Campus St.-Jan, Genk, Belgium. Geert.robaeys@zol.be

    , , , , , ,

    Source

    Transplantation proceedings 41:2 2009 Mar pg 589-94

    MeSH

    Biopsy
    Female
    Graft Rejection
    Graft Survival
    Hepatitis C, Chronic
    Humans
    Immunosuppressive Agents
    Liver Diseases
    Liver Transplantation
    Male
    Methadone
    Middle Aged
    Postoperative Complications
    Retrospective Studies
    Substance Abuse, Intravenous
    Survival Analysis
    Survivors
    Treatment Outcome
    Waiting Lists

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19328933

    Citation

    Robaeys, G, et al. "Previous Intravenous Substance Use and Outcome of Liver Transplantation in Patients With Chronic Hepatitis C Infection." Transplantation Proceedings, vol. 41, no. 2, 2009, pp. 589-94.
    Robaeys G, Nevens F, Stärkel P, et al. Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. Transplant Proc. 2009;41(2):589-94.
    Robaeys, G., Nevens, F., Stärkel, P., Colle, I., Van Eyken, P., Bruckers, L., ... Buntinx, F. (2009). Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. Transplantation Proceedings, 41(2), pp. 589-94. doi:10.1016/j.transproceed.2009.01.003.
    Robaeys G, et al. Previous Intravenous Substance Use and Outcome of Liver Transplantation in Patients With Chronic Hepatitis C Infection. Transplant Proc. 2009;41(2):589-94. PubMed PMID: 19328933.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Previous intravenous substance use and outcome of liver transplantation in patients with chronic hepatitis C infection. AU - Robaeys,G, AU - Nevens,F, AU - Stärkel,P, AU - Colle,I, AU - Van Eyken,P, AU - Bruckers,L, AU - Van Ranst,M, AU - Buntinx,F, PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/7/30/medline SP - 589 EP - 94 JF - Transplantation proceedings JO - Transplant. Proc. VL - 41 IS - 2 N2 - BACKGROUND: End-stage liver disease due to hepatitis C viral (HCV) infection is the most common reason for liver transplantation. One of the major risk factors for infection with HCV is intravenous drug use (IVDU). The pretransplantation characteristics and outcome of liver transplantation in patients with chronic hepatitis C (CHC) infected after IVDU are poorly known. METHODS: We performed a retrospective cohort study in patients with CHC who underwent liver transplantation between 1998 and 2002 in Belgium. Seven patients with and 60 patients without a history of IVDU were compared. RESULTS: Patients with CHC infected after IVDU were primarily men, significantly younger, and affected more by genotype 2 or 3. There was no relapse in substance use. No patients required a second transplantation or developed surgical complications. Progression to fibrosis in the posttransplantation period seemed to be slower. Graft and patient survival, and compliance were similar in both groups. CONCLUSIONS: Compared with patients in the non-IVDU group, patients with CHC infected after IVDU in complete remission have the same compliance, and patient and graft survival after liver transplantation. Therefore, patients with IVDU should not be excluded for liver transplantation because of HCV-induced cirrhosis. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/19328933/Previous_intravenous_substance_use_and_outcome_of_liver_transplantation_in_patients_with_chronic_hepatitis_C_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(09)00004-9 DB - PRIME DP - Unbound Medicine ER -