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Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT).
Eur Neuropsychopharmacol. 2009 Sep; 19(9):636-47.EN

Abstract

Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. The aim of the present study was to examine the modulating impacts of CUR against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (ICV-STZ) infused rats. Rats were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with CUR (80 mg/kg) for three weeks. After two weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks and then sacrificed for biochemical and histopathological assays. ICV-STZ rats showed significant cognitive deficits, which were significantly improved by CUR supplementation. CUR supplementation significantly augmented increased 4-hydroxynonenal (4-HNE) and malonaldehyde (MDA), thiobarbituric reactive substances (TBARS), hydrogen peroxide (H2O2), protein carbonyl (PC) and oxidized glutathione (GSSG); decreased levels of reduced glutathione (GSH) and its dependent enzymes (Glutathione peroxidase [GPx] and glutathione reductase [GR]) in the hippocampus and cerebral cortex; and increased choline acetyltransferase (ChAT) activity in the hippocampus of ICV-STZ rats. The study suggests that CUR is effective in preventing cognitive deficits, and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).

Authors+Show Affiliations

Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19329286

Citation

Ishrat, Tauheed, et al. "Amelioration of Cognitive Deficits and Neurodegeneration By Curcumin in Rat Model of Sporadic Dementia of Alzheimer's Type (SDAT)." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 19, no. 9, 2009, pp. 636-47.
Ishrat T, Hoda MN, Khan MB, et al. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). Eur Neuropsychopharmacol. 2009;19(9):636-47.
Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., & Islam, F. (2009). Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 19(9), 636-47. https://doi.org/10.1016/j.euroneuro.2009.02.002
Ishrat T, et al. Amelioration of Cognitive Deficits and Neurodegeneration By Curcumin in Rat Model of Sporadic Dementia of Alzheimer's Type (SDAT). Eur Neuropsychopharmacol. 2009;19(9):636-47. PubMed PMID: 19329286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). AU - Ishrat,Tauheed, AU - Hoda,Md Nasrul, AU - Khan,M Badruzzaman, AU - Yousuf,Seema, AU - Ahmad,Muzamil, AU - Khan,Mohd Moshahid, AU - Ahmad,Ajmal, AU - Islam,Fakhrul, Y1 - 2009/03/28/ PY - 2008/10/20/received PY - 2009/01/28/revised PY - 2009/02/10/accepted PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/12/16/medline SP - 636 EP - 47 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 19 IS - 9 N2 - Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. The aim of the present study was to examine the modulating impacts of CUR against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (ICV-STZ) infused rats. Rats were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with CUR (80 mg/kg) for three weeks. After two weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks and then sacrificed for biochemical and histopathological assays. ICV-STZ rats showed significant cognitive deficits, which were significantly improved by CUR supplementation. CUR supplementation significantly augmented increased 4-hydroxynonenal (4-HNE) and malonaldehyde (MDA), thiobarbituric reactive substances (TBARS), hydrogen peroxide (H2O2), protein carbonyl (PC) and oxidized glutathione (GSSG); decreased levels of reduced glutathione (GSH) and its dependent enzymes (Glutathione peroxidase [GPx] and glutathione reductase [GR]) in the hippocampus and cerebral cortex; and increased choline acetyltransferase (ChAT) activity in the hippocampus of ICV-STZ rats. The study suggests that CUR is effective in preventing cognitive deficits, and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT). SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/19329286/Amelioration_of_cognitive_deficits_and_neurodegeneration_by_curcumin_in_rat_model_of_sporadic_dementia_of_Alzheimer's_type__SDAT__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(09)00049-2 DB - PRIME DP - Unbound Medicine ER -